1-methyl-5-phenyl-5-propylbarbituric acid (MPPB)

barbiturate deriv whose activities are related to the optical properties; the (-)-deriv depresses CNS activities, while the (+)-deriv induces convulsion; RN given refers to cpd without isomeric designation; structure given in first source

Also Known As:

MPPB; 1-methyl-5-phenyl-5-propylbarbiturate; 1-methyl-5-phenyl-5-propylbarbituric acid, (+-)-isomer; 1-methyl-5-phenyl-5-propylbarbituric acid, (R)-isomer; 1-methyl-5-phenyl-5-propylbarbituric acid, (S)-isomer; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-phenyl-5-propyl-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Barbiturates: 1074
        Phenobarbital: 21141
        1-methyl-5-phenyl-5-propylbarbituric acid: 2

Related Diseases

1.	Seizures (Absence Seizure) 05/28/1985 - "S(+)MPPB-induced seizures were blocked by R(-)MPPB and pentobarbital. "
2.	Bradycardia 01/01/1982 - "The enantiomers of MPPB and MPBB exhibit stereoselectively different influence on the sympathetic outflow of intact rats during barbiturate-induced hypotension and bradycardia: 1 min after injection the efferent activity of neck sympathetic nerve is increased only if the (+)-enantiomers are given (twofold of the control). "

Related Drugs and Biologics

1.	Pentobarbital (Nembutal)
2.	1-methyl-5-phenyl-5-butylbarbituric acid
3.	barbituric acid (barbiturate)

Related Therapies and Procedures

1.	Controlled Hypotension