5'-methylthioadenosine

structure

Also Known As:

5'-deoxy-5'-(methylthio)adenosine; 5'-deoxy-5'-methylthioadenosine; 5'-methylthio-5'-deoxyadenosine; 5'-methylthioadenosine, methyl-(14)C-labeled; 5-MTDA; adenine(5'-deoxy-5'-methylthio)9-beta-D-furanoriboside

Networked: 59 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dettmer, Katja: 6 articles (08/2016 - 12/2008)
2.	Oefner, Peter J: 6 articles (08/2016 - 12/2008)
3.	Bosserhoff, Anja K: 4 articles (03/2011 - 12/2008)
4.	Stevens, Axel P: 4 articles (03/2011 - 12/2008)
5.	Bosserhoff, Anja-Katrin: 3 articles (08/2016 - 10/2014)
6.	Limm, Katharina: 3 articles (08/2016 - 10/2014)
7.	Wallner, Susanne: 3 articles (10/2014 - 12/2008)
8.	Aigner, Michael: 2 articles (01/2020 - 08/2016)
9.	Jacobs, Benedikt: 2 articles (01/2020 - 08/2016)
10.	Mackensen, Andreas: 2 articles (01/2020 - 08/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "5'-Methylthioadenosine and Cancer: old molecules, new understanding." 01/01/2018 - "Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine." 08/01/2016 - "Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells." 01/15/1990 - "Measurement of 5'-methylthioadenosine in patients with neoplasms." 11/28/1984 - "5'-Methylthioadenosine in urine from normal subjects and cancer patients."
2.	Acute Erythroblastic Leukemia (Erythroleukemia) 10/15/1984 - "Effect of 5'-methylthioadenosine on induction of murine erythroleukemia cell differentiation." 10/15/1984 - "Since 5'-methylthioadenosine is also a known inhibitor of DNA methylation, this naturally occurring nucleoside may be an intermediate involved in both murine erythroleukemia cell proliferation and differentiation." 11/01/1985 - "Recent studies have demonstrated that 5'-methylthioadenosine, an inhibitor of S-adenosylhomocysteine (AdoHcy) hydrolase, blocks induction of murine erythroleukemia cell (MEL) differentiation. " 10/15/1984 - "The present study has monitored the effects of 5'-methylthioadenosine, the metabolic product of spermidine and spermine synthesis, on the appearance of a differentiated murine erythroleukemia cell phenotype. " 10/15/1984 - "The results demonstrate that increasing concentrations of 5'-methylthioadenosine (1 X 10(-6) to 5 X 10(-4)M) progressively inhibit murine erythroleukemia cell heme synthesis and hemoglobin production. "
3.	Melanoma (Melanoma, Malignant) 02/01/2009 - "Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma." 10/01/2014 - "The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma." 12/01/2008 - "Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry." 03/26/1991 - "Serum has a differential effect on DNA replication in a human melanoma cell line cultured in methionine or 5'-deoxy-5'-methylthioadenosine." 10/01/2014 - "We recently discovered a lack of methylthioadenosine phosphorylase (MTAP) expression in melanoma, which resulted in an accumulation of the metabolite 5'-methylthioadenosine (MTA) in melanoma cells and in the extracellular environment. "
4.	Leukemia 07/15/1987 - "Influx of 5'-deoxy-5'-methylthioadenosine into HL-60 human leukemia cells and erythrocytes." 05/01/1998 - "Induction of apoptosis in leukemia U937 cells by 5'-deoxy-5'-methylthioadenosine, a potent inhibitor of protein carboxylmethyltransferase." 07/15/1987 - "The influx of 5'-deoxy-5'-methylthioadenosine (MeSAdo) into human HL-60 leukemia cells and erythrocytes was characterized in order to determine whether it is facilitated by the nonspecific nucleoside carrier system or by a separate transporter, as suggested by other reports. " 05/01/1998 - "We found dramatic changes in leukemia U937 cells treated with 5'-deoxy-5'-methylthioadenosine (MTA), a potent inhibitor of protein carboxylmethyltransferase (protein methylase II). " 11/01/1980 - "Using two 5'-methylthioadenosine phosphorylase-negative leukemias, we have for the first time been able to measure the synthesis and biological effects of 5'-methylthioadenosine (MTA) in intact mammalian tumor cells. "
5.	Hepatocellular Carcinoma (Hepatoma) 05/01/2011 - "Identification of a 2-cell stage specific inhibitor of the cleavage of preimplantation mouse embryos synthesized by rat hepatoma cells as 5'-deoxy-5'-methylthioadenosine." 06/01/1986 - "The hepatic levels of 5'-deoxy-5'-methylthioadenosine (MTA) were measured in the livers of adult male Sprague-Dawley rats a) killed at various times during the liver regeneration process, b) killed at times after partial hepatectomy when the liver mass had already been completely restored (hereafter called post-regeneration livers), or c) continuously fed 3'-methyl-4-dimethyl-aminoazobenzene (CAS: 55-80-1) up to the full development of hepatoma and killed at regular intervals during hepatocarcinogenesis. " 03/01/2011 - "Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA)." 05/01/1987 - "Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma." 11/01/2019 - "The 5'-methylthioadenosine (MTA) cycle-participating human acireductone dioxygenase 1 (ADI1) has been implicated as a tumor suppressor in prostate cancer, yet its role remains unclear in hepatocellular carcinoma (HCC). "

Related Drugs and Biologics

1.	Nucleosides
2.	purine
3.	Therapeutic Uses
4.	Threonine (L-Threonine)
5.	S-Adenosylhomocysteine
6.	Spermine
7.	Spermidine
8.	Hydrolases
9.	Pemetrexed (MTA)
10.	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Therapeutics
3.	Hepatectomy