maltol

found in bark of young larch trees; isolated from Passiflora incarnata; possesses depressant properties in mice; potentiates hexobarbital-induced narcosis & inhibits spontaneous motor activity; structure

Also Known As:

Networked: 41 relevant articles (5 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Wei: 4 articles (04/2022 - 02/2019)
2.	Wang, Zi: 3 articles (04/2022 - 02/2019)
3.	Jiang, Shuang: 3 articles (08/2021 - 02/2019)
4.	Chen, Chen: 2 articles (04/2022 - 02/2019)
5.	Hou, Jin-Gang: 2 articles (04/2022 - 02/2019)
6.	Mi, Xiao-Jie: 2 articles (04/2022 - 02/2019)
7.	Wang, Ying-Ping: 2 articles (08/2021 - 02/2019)
8.	Xu, Caimin: 2 articles (12/2018 - 03/2006)
9.	Kontoghiorghe, Christina N: 2 articles (03/2016 - 11/2015)
10.	Kontoghiorghes, George J: 2 articles (03/2016 - 11/2015)

Related Diseases

1.	Iron Deficiencies 07/01/2000 - "Iron trimaltol is a novel, stable complex, formed between ferric iron (Fe3+) and maltol (3-hydroxy-2-methyl-4-pyrone), and is effective in the treatment of iron deficiency anaemia with few side-effects. " 06/01/2023 - "The half-lives of maltol and maltol glucuronide were 0.90 ± 0.40 h and 1.02 ± 0.25 h in the iron deficiency patients, respectively. " 06/01/2023 - "Simultaneous determination of maltol and maltol glucuronide in human plasma and urine by HPLC-MS/MS: Application in clinical study in patients with iron deficiency." 04/01/1990 - "Maltol itself may delay recycling of Fe3+ to Fe2+. Thus ferric maltol could provide a less toxic alternative to ferrous salts in the oral treatment of iron-deficiency." 11/23/2015 - "The phytochelators mimosine and tropolone have been identified to be orally active and effective in animal models for the treatment of iron overload and maltol for the treatment of iron deficiency anaemia. "
2.	Iron Overload 03/01/1987 - "Enhanced 59Fe uptake from maltol was evident at 0.7-70 micrograms but not at 700 micrograms suggesting that use of these pyrones will not result in iron overload. " 11/23/2015 - "The phytochelators mimosine and tropolone have been identified to be orally active and effective in animal models for the treatment of iron overload and maltol for the treatment of iron deficiency anaemia. " 03/26/2016 - "New developments include the complete treatment of iron overload and reduction of morbidity and mortality in thalassaemia using deferiprone and selected deferiprone/deferoxamine combinations and also the use of the maltol iron complex in the treatment of iron deficiency anaemia. " 08/01/2022 - "This work evaluated key chemical and biological properties of five candidate phytochelators for iron overload diseases: maltol, mimosine, morin, tropolone, and esculetin. "
3.	Cardiotoxicity 04/01/2022 - "In mice, maltol apparently induced PI3K/Akt in heart tissues and protected against cisplatin-induced cardiotoxicity. " 04/01/2022 - "Maltol mitigates cisplatin-evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro." 04/01/2022 - "In conclusion, maltol exerted the protective effects against cisplatin-induced cardiotoxicity, at least partially by inhibiting the activation of PI3K/Akt signaling pathways in cardiomyocytes, to ease oxidative stress, and alleviate reactive oxygen species-mediated apoptosis." 04/01/2022 - "Our current research aims to evaluate the efficiency of a flavor enhancer, maltol (produced by heating ginseng) against cisplatin-evoked cardiotoxicity by establishing cisplatin-induced heart injury in vivo and H9C2 rat cardiomyocyte model. "
4.	Intervertebral Disc Degeneration 02/01/2023 - "Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis."
5.	Hyperalgesia 12/13/2018 - "Repeated treatment with maltol for 12 weeks significantly improved thermal and mechanical hyperalgesia, increased the MNCV, elevated the Na+-K+-ATPase activity, and ameliorated oxidative stress and apoptosis in STZ-induced diabetic rats. "

Related Drugs and Biologics

1.	Iron
2.	Cisplatin (Platino)
3.	Tropolone
4.	Mimosine
5.	Inflammasomes
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Adenosine Triphosphatases (ATPase)
8.	Type I Tumor Necrosis Factor Receptors
9.	Small Interfering RNA (siRNA)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Immunotherapy