HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

4-(N-maleimido)benzyltrimethylammonium (MPTA)

affinity-alkylating agent; RN given refers to parent cpd
Also Known As:
MPTA; 4-(N-maleimido)benzyltrimethylammonium iodide; benzenemethanaminium, 4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-N,N,N-trimethyl-
Networked: 77 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Devor, Marshall: 9 articles (11/2021 - 10/2001)
2. Minert, Anne: 6 articles (11/2021 - 01/2016)
3. Devor, M: 4 articles (05/2008 - 12/2006)
4. Sukhotinsky, I: 4 articles (05/2008 - 12/2006)
5. Kronenberg, Jona: 3 articles (09/2011 - 02/2005)
6. Reiner, K: 3 articles (05/2008 - 12/2006)
7. Akiyama, Haruhiko: 2 articles (09/2022 - 10/2019)
8. Matsumoto, Kazu: 2 articles (09/2022 - 10/2019)
9. Ogawa, Hiroyasu: 2 articles (09/2022 - 10/2019)
10. Fishman, Yelena: 2 articles (01/2020 - 01/2018)

Related Diseases

1. Congenital Abnormalities (Deformity)
11/01/2023 - "Outliers were defined as follows: Δ Cartier > 3° (difference between the preoperative and postoperative Cartier angle); Δ MPTA (Medial Proximal Tibial angle) and postoperative TCA (Tibial Coronal component Angle) > 3° (difference between the positioning of the tibial implant and the preoperative proximal tibial deformity). "
09/30/2023 - "Pre-operative data was, HKA at 176.7 ± 6.3, mLDFA at 90.6 ± 5.4, MPTA 88.9 ± 1.1, a WBL for valgus 80.9% ± 9.1 and for varus deformity 23.5% ± 11.7. "
06/10/2023 - "Radiological evaluation was performed using long film from hip to knee to ankle (HKA) radiographs; the overall mechanical alignment was measured as the HKA angle, the upper tibial deformity was measured as the medial proximal tibial angle (MPTA), and the joint line convergence angle (JLCA) was measured. "
06/01/2023 - "Measurements were compared between single-leg and double-leg standing radiographs for KJLO measurement methods including joint line orientation angle by femoral condyles (JLOAF), joint line orientation angle by middle knee joint space (JLOAM), joint line orientation angle by tibial plateau (JLOAT), Mikulicz joint line angle (MJLA) and medial proximal tibial angle (MPTA), as well as KJLO-related frontal deformity parameters including joint line convergence angle (JLCA), knee ankle joint angle (KAJA) and hip-knee-ankle angle (HKA). "
05/01/2023 - "Closure of a proximal femoral physis decreased the odds of success for postoperative-MPTA by 91% with first LTTBP and for final-mTFA by 90% with GMS, controlling for preoperative deformity. "
2. Neoplasms (Cancer)
3. Osteoarthritis
06/01/2020 - "The tibial side mismatch was within 1.5 mm, the medial and lateral plateau were relatively undercut by 0.43 mm and 0.32 mm. HKA was corrected from (8.8±5.6) ° to (1.6±4.3) ° (t=20.723, P=0.000) .KS-C improved from 28.21±13.47 preoperative to 78.07±8.01 postoperative (t=-16.570, P=0.000); KS-F improved from 41.00±15.25 preoperative to 84.93±10.85 postoperative (t=-14.675, P=0.000).WOMAC Osteoarthritis Index decreased from 53.5 (25.75) (M(Q(R))) preoperative to 5.5 (5.25) postoperative (Z=-3.297, P=0.001) .No statistically significant difference was found in mLDFA and MPTA before and after surgery. "
11/01/2023 - "Increased KJLO (postoperative MPTA ≥ 95.0°) or MPTA change ≥ 8.0° after lateral closing-wedge HTO does not adversely affect patient-reported outcome, radiological progression of osteoarthritis, or surgical survival at an average 5-year follow-up. "
11/01/2023 - "To assess the association between KJLO and patient-reported outcome, radiological progression of osteoarthritis, and surgical survival, patient groups were defined: I, postoperative MPTA < 95.0°; II, postoperative MPTA ≥ 95.0°; A, MPTA change < 8.0°; B, MPTA change ≥ 8.0°. "
06/01/2023 - "Knee joint obliquity as assessed by MPTA measurement is independent of single-leg/double-leg standing, bipedal distance or osteoarthritis grade, and has excellent measurement reliability. "
04/15/2023 - "There was no significant difference between the two groups ( P>0.05) in terms of gender, age, body mass index, osteoarthritis side, disease duration, and preoperative Knee Society Score (KSS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), visual analogue scale (VAS) score, hip-knee-ankle angle (HKA), lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), and posterior proximal tibial angle (PPTA). "
4. Knee Osteoarthritis
5. Body Weight (Weight, Body)

Related Drugs and Biologics

1. Antibodies
2. Anesthetics (Anesthetic Agents)
3. MME
4. Pain-Free
5. Pentobarbital (Nembutal)
6. gamma-Aminobutyric Acid (GABA)
7. GABA-A Receptor Agonists
8. GABA Agents
9. ATP-Binding Cassette Transporters (ABC Transporters)
10. 2,2'-Dipyridyl (2,2 Bipyridine)

Related Therapies and Procedures

1. Knee Replacement Arthroplasty (Total Knee Replacement)
2. Osteotomy
3. Preoperative Period
4. Analgesia
5. Anesthesia