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15-keto-13,14-dihydroprostaglandin F2alpha (PGFM)

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main metabolite of PGF2alpha in plasma after allergen provoked asthma; RN given refers to (5Z,9alpha,11alpha)-isomer; structure

Also Known As:

PGFM; 13,14-dihydro-15-keto-PGF2alpha; 13,14-dihydro-15-ketoprostaglandin F; 13,14-dihydro-15-ketoprostaglandin F2alpha; 13,14-dihydro-15-oxoprostaglandin F; 15-K-DH-PGF(2alpha); 15-keto-13,14-dihydro-PGF2alpha; 15-keto-13,14-dihydro-prostaglandin F2alpha; 15-keto-dihydro-PGF2alpha; DHK-PGF2alpha; pulmonary metabolite-PGF2alpha; (5Z,9 alpha, 11 alpha)-9,11-dihydroxy-15-oxoprost-5-en-1-oic acid

Networked: 69 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Basu, Samar: 8 articles (07/2007 - 03/2003)
2.	Jynge, Per: 3 articles (10/2006 - 05/2004)
3.	Skarra, Sissel: 3 articles (10/2006 - 05/2004)
4.	Wiseth, Rune: 3 articles (10/2006 - 05/2004)
5.	Berg, Kirsti: 3 articles (10/2006 - 05/2004)
6.	Kindahl, H: 2 articles (05/2010 - 12/2009)
7.	Kobayashi, Syuichi: 2 articles (03/2009 - 08/2008)
8.	Yamanoi, Takahiro: 2 articles (03/2009 - 08/2008)
9.	Matsui, Motozumi: 2 articles (03/2009 - 08/2008)
10.	Acosta, Tomas J: 2 articles (03/2009 - 08/2008)

Related Diseases

1.	Premature Obstetric Labor (Premature Labor) 04/01/1986 - "The mean initial PGFM level was significantly higher in patients who delivered preterm (65.9 +/- 9.7 pg/mL; N = 14) than in patients not in preterm labor (32.1 +/- 4.3 pg/mL; N = 11; P less than .01). " 06/01/1978 - "The concentration of PGFM in plasma from patients in preterm labor (62.7 +/- 17.4 pg/ml) was not significantly different from that found during late pregnancy, but was significantly lower than levels found at term during early labor (P less than 0.05). " 04/01/1986 - "Two of four patients not considered to be in preterm labor but who delivered prematurely (within five days of initial evaluation) had initial PGFM concentrations of greater than 55 pg/mL. Concentration determinations of PGFM might be a useful adjunct in identifying early preterm labor and in predicting success of tocolytic therapy." 01/01/1989 - "Amniotic fluid concentrations of PGFM and PGEM-ll were significantly greater in women with preterm labor and intra-amniotic infection than in women without infection. " 01/01/1989 - "Amniotic fluid concentrations of prostaglandin F2 alpha, 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) and 11-deoxy-13,14-dihydro-15-keto-11, 16-cyclo-prostaglandin E2 (PGEM-LL) in preterm labor."
2.	Infection 09/15/2003 - "The PGFM levels stayed high in peripheral circulation of buffaloes with reproductive tract infections and remained low throughout the sampling period in buffaloes having persistent corpus luteum. " 01/01/1987 - "Therefore, uterine infections in cows during the puerperium was associated with elevated circulating PGFM levels. " 01/01/1989 - "In addition, patients unresponsive to tocolysis without intra-amniotic infection also had a significantly greater concentration of PGFM and PGEM-ll in amniotic fluid than those responsive to tocolysis. " 01/01/1989 - "Amniotic fluid concentrations of PGFM and PGEM-ll were significantly greater in women with preterm labor and intra-amniotic infection than in women without infection. " 11/01/2005 - "Concentrations of PGFM associated with postpartum endometritis were elevated as compared to those in buffaloes free of reproductive tract infections. "
3.	Endometriosis (Adenomyosis) 06/01/1982 - "Prostanoid concentrations (PGE2, PGF2 alpha, PGFM, TXB2) in women with endometriosis were not significantly different from a comparable group of disease-free women. " 06/01/1982 - "Cul-de-sac fluid from women with histologically confirmed endometriosis (n = 45) or with no evidence of endometriosis (n = 17) was removed during the proliferative phase of the menstrual cycle (days 8 to 12) and analyzed for prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), 15-keto-13,14-dihydroprostaglandin F2 alpha (PGFM), and thromboxane B2 (TXB2). "
4.	Retained Placenta 03/01/2009 - "The OT concentration was increased before placental expulsion in all the mares, and the PGFM concentration also increased in the two mares with retained placentas. " 09/01/1992 - "Cows with retained placentas and fed grass silage had less PGFM (2172 vs 4530 pg/ml; P<0.05) than cows without retained placentas and fed the same forage. " 09/01/1992 - "Blood levels of prostaglandin metabolites (PGFM, PGEM) after parturition in cows with and without retained placenta considering spontaneous calving and dystocia." 09/01/1992 - "Furthermore, their plasma PGFM -PgF2alpha main metabolite- (3325 vs 5675 pg/ml; P<0.01) and glucose (79.2 vs 95.2 mg/100ml; P<0.05) levels were lower and their protein concentration was higher (85.7 vs 76.5 g/l; P<0.05) than those of cows without retained placentas. " 09/01/1997 - "It may be concluded that a large amount of PGF2 alpha is released for a relatively shorter period in cows after dystocia and/or retained placenta and the elevation of PGFM is not responsible for the uterine involution. "
5.	Rupture 10/29/1982 - "In the present study the concentration of 13,14-dihydro,15-ketoprostaglandin F2 (PGFM) in the maternal peripheral plasma was determined in labor of spontaneous onset, in labor after induction with oxytocin and in labor after induction by artificial rupture of membranes (ARM). " 04/01/1989 - "To investigate why premature rupture of membranes (PROM) often fails to initiate uterine contractions, we measured plasma concentrations of PGFM and oxytocin (OT) in patients with PROM near term. " 04/01/1989 - "Rupture of membranes at term, whether spontaneous or artificial, causes rapid and sustained increase in prostaglandin F2 alpha (PGF2 alpha) metabolite (PGFM) levels and is associated with augmentation of uterine contractions. " 11/01/1988 - "Maximal concentrations of PGFM (approximately 30 ng/ml) and oxytocin (greater than 200 microU/ml) were measured between rupture of the chorioallantois and the completion of delivery. " 12/01/1984 - "PGFM plasma levels will rise only slightly within an hour after intracervical PGE2 gel administration, independent of whether there has been a rupture or not, or whether the cervix is dilated less than 2 cm or 2 cm and more.(ABSTRACT TRUNCATED AT 250 WORDS)"

Related Drugs and Biologics

1.	Dinoprost
2.	Dinoprostone (PGE2)
3.	Oxytocin (Pitocin)
4.	Prostaglandins F (PGF)
5.	Prostaglandins E (PGE)
6.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7.	Interleukin-6 (Interleukin 6)
8.	alpha-Tocopherol
9.	Arachidonic Acid (Vitamin F)
10.	C-Reactive Protein

Related Therapies and Procedures

1.	Tocolysis
2.	Catheters
3.	Cardiopulmonary Resuscitation (CPR)
4.	Lasers (Laser)
5.	Intravenous Injections