4-ketocyclophosphamide

metabolite of cyclophosphamide; RN given refers to cpd without isomeric designation; structure

Also Known As:

4-ketocyclophosphamide, (R)-isomer; 4-ketocyclophosphamide, (S)-isomer; 2-(bis(2-chloroethyl)amino)tetrahydro-4H-1,3,2-oxazaphosphorin-4-one 2-oxide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Osteosarcoma (Osteogenic Sarcoma) 04/01/1976 - "The biologic activity in terms of survival of normal hematopoietic stem, osteosarcoma, and L1210 leukemia cells was determined for the following compounds:cyclophosphamide, its derivatives isophosphamide and trophosphamide, its possible metabolites nor-nitrogen mustard, hydroxylamine mustard, 4-ketocyclophosphamide, and and acrolein, and two substitutes for its primary active metabolite 4-hydroxycyclosphamide anhydro-dimer (4-hydroxy-CP-anhydro-dimer) and 4-hydroperoxycyclophosphamide (4-hydroperoxy-CP). "
2.	Multiple Sclerosis 11/01/1981 - "The off-line combination of high pressure liquid chromatography and field desorption mass spectrometry has been used for the simultaneous isolation, identification and determination of cyclophosphamide and two of its metabolites, 4-ketocyclophosphamide and carboxyphosphamide in urine from a patient suffering from multiple sclerosis. "
3.	Leukemia L1210 04/01/1976 - "The biologic activity in terms of survival of normal hematopoietic stem, osteosarcoma, and L1210 leukemia cells was determined for the following compounds:cyclophosphamide, its derivatives isophosphamide and trophosphamide, its possible metabolites nor-nitrogen mustard, hydroxylamine mustard, 4-ketocyclophosphamide, and and acrolein, and two substitutes for its primary active metabolite 4-hydroxycyclosphamide anhydro-dimer (4-hydroxy-CP-anhydro-dimer) and 4-hydroperoxycyclophosphamide (4-hydroperoxy-CP). "

1.	Cyclophosphamide (Cytoxan)
2.	Hydroxylamine (Hydroxylamine Hydrochloride)
3.	Ifosfamide
4.	Acrolein (Aqualin)
5.	perfosfamide
6.	nornitrogen mustard
7.	trofosfamide
8.	carboxyphosphamide