isomaltulose (palatinose)

Also Known As:

palatinose; 6-O alpha-D-glucopyranosyl-D-fructose; D-fructose, 6-O-alpha-D-glucopyranosyl-, monohydrate; isomaltulose anhydrous; isomaltulose monohydrate; palatinose monohydrate; 6-O alpha-D-glucosylpyranosyl-D-fructose

Networked: 54 relevant articles (9 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - Disaccharides: 990
      - Isomaltose: 15
        isomaltulose: 54
  - Glucans: 1624
    - Isomaltose: 15
      - isomaltulose: 54
- Sugars: 11126
  - Disaccharides: 990
    - Isomaltose: 15
      - isomaltulose: 54

Experts

1.	Sasaki, Hajime: 8 articles (09/2015 - 08/2004)
2.	Takeda, Eiji: 6 articles (09/2015 - 08/2004)
3.	Taketani, Yutaka: 6 articles (09/2015 - 08/2004)
4.	Arai, Hidekazu: 6 articles (03/2010 - 08/2004)
5.	Theis, Stephan: 5 articles (01/2020 - 06/2012)
6.	Doi, Toshio: 4 articles (09/2009 - 08/2004)
7.	Fukaya, Makiko: 4 articles (09/2009 - 08/2004)
8.	Mizuno, Akira: 4 articles (09/2009 - 08/2004)
9.	Yamamoto, Hironori: 4 articles (09/2009 - 11/2005)
10.	Schweitzer, Lisa: 3 articles (01/2020 - 10/2019)

Related Diseases

1.	Hyperglycemia 12/15/2021 - "The purpose of this study was to determine the efficacy of low-glycemic-index isomaltulose on arterial stiffness during hyperglycemia in middle-aged and older adults. " 09/30/2023 - "Habitual isomaltulose intake reduces arterial stiffness associated with postprandial hyperglycemia in middle-aged and elderly people: a randomized controlled trial." 01/01/2020 - "We hypothesized that PS mixtures containing 30% or 50% palatinose might demonstrate improvement of hyperglycemia. " 10/01/2014 - "However, the mechanism by which isomaltulose limits postprandial hyperglycemia has not been clarified. " 11/01/2005 - "Therefore, the effects of palatinose based functional food which reduces postprandial hyperglycemia and hyperinsulinemia were investigated in rats. "
2.	Insulin Resistance 01/01/2020 - "This resulted in ∼35 - 50% improved insulin sensitivity and reduced insulinogenic index after isomaltulose, which correlated closely with improved HIC, respectively (r = 0.62, r=-0.70; p < 0.001). " 08/01/2018 - "Together, it present study demonstrated that isomaltulose improved insulin resistance in NAFLD patients. " 08/01/2018 - "The present study aimed to investigate the effects of isomaltulose on insulin resistance and various metabolites in NAFLD patients. " 08/01/2018 - "Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis." 09/01/2018 - "This transient replacement of carbohydrate with isomaltulose, together with exercise, represents a potentially effective approach for the management of insulin resistance."
3.	Overweight 11/01/2009 - "The metabolic response to isomaltulose co-ingestion suggests that this may represent an effective nutritional strategy to counteract overweight-induced metabolic disturbances." 01/01/2020 - "Comment on: Changes in Weight and Substrate Oxidation in Overweight Adults Following Isomaltulose Intake during a 12-Week Weight Loss Intervention: A Randomized, Double-Blind, Controlled Trial. " 01/01/2020 - "Comment on: "Changes in Weight and Substrate Oxidation in Overweight Adults Following Isomaltulose Intake during a 12-Week Weight Loss Intervention: A Randomized, Double-Blind, Controlled Trial". " 10/04/2019 - "Changes in Weight and Substrate Oxidation in Overweight Adults Following Isomaltulose Intake During a 12-Week Weight Loss Intervention: A Randomized, Double-Blind, Controlled Trial." 06/01/2012 - "Postprandial substrate use in overweight subjects with the metabolic syndrome after isomaltulose (Palatinose™) ingestion."
4.	Obesity 08/01/2007 - "The combination of palatinose and oleic acid holds promise for a new approach to preventing and treating obesity and its complications." 05/01/2007 - "The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR-alpha and Adipocyte PPAR-gamma Gene Expressions." 04/21/2021 - "An alcohol-free beer enriched with isomaltulose and a resistant dextrin modulates gut microbiome in subjects with type 2 diabetes mellitus and overweight or obesity: a pilot study." 01/01/2020 - "Effect of an alcohol-free beer enriched with isomaltulose and a resistant dextrin on insulin resistance in diabetic patients with overweight or obesity." 04/21/2021 - "Thus, an alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and the addition of maltodextrin within meals significantly impacts gut microbiota in diabetic subjects with overweight or obesity. "
5.	Type 2 Diabetes Mellitus (MODY) 09/01/2009 - "Intake of 1046 kJ palatinose-formula as a part of breakfast over a long-term period may be effective for improvement of glucose metabolism in patients with IGT or type 2 diabetes." 06/01/2012 - "Metabolic effects of replacing sucrose by isomaltulose in subjects with type 2 diabetes: a randomized double-blind trial." 09/01/2009 - "Two patients with IGT and 7 patients with type 2 diabetes participated in the palatinose-formula and dextrin-based liquid formula (dextrin-formula) loading test and long-term palatinose-formula administration study. " 03/01/2016 - "To investigate the effect of isomaltulose (ISO) and sucrose (SUC) based breakfast on the postprandial substrate oxidation and glycemic/insulinemic changes in type 2 diabetes mellitus subjects (T2DM). " 06/01/2012 - "One hundred ten patients with type 2 diabetes were randomized to receive sweet foods containing either 50 g/day isomaltulose or sucrose for 12 weeks as part of their habitual diet under free-living conditions. "

Related Drugs and Biologics

1.	Sucrose (Saccharose)
2.	Glucose (Dextrose)
3.	Carbohydrates
4.	maltodextrin
5.	Oleic Acid (Oleate)
6.	isomaltulose (palatinose)
7.	Sweetening Agents (Sweeteners)
8.	Dextrins
9.	Acids
10.	Suspensions

Related Therapies and Procedures

1.	Glycemic Control
2.	Fluid Therapy (Oral Rehydration Therapy)
3.	Aftercare (After-Treatment)
4.	Oral Administration