3,3'-iminodipropionitrile

lathyrogen; RN refers to parent cpd; blocks axoplasmic transport of neurofilament proteins with subsequent axon swelling typical of some motor neuron diseases

Also Known As:

3,3'-iminobispropanenitrile; 3,3'-iminodipropionitrile fumarate; 3,3'-iminodipropionitrile monohydrochloride; 3,3'-iminodipropionitrile sulfate (1:1); NSC-7770; beta,beta'-iminodipropionitrile; bis(2-cyanoethyl)amine; bis(beta-cyanoethyl)amine; bis-(2-cyanoethyl)amine; crotonitrile

Networked: 38 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitriles: 227
  - 3,3'-iminodipropionitrile: 38

Experts

1.	Li, Anyuan: 3 articles (09/2020 - 01/2015)
2.	Zhang, Feng: 3 articles (05/2015 - 01/2015)
3.	Boadas-Vaello, Pere: 2 articles (01/2019 - 06/2014)
4.	Llorens, Jordi: 2 articles (01/2019 - 06/2014)
5.	Jinno, Shozo: 2 articles (08/2017 - 01/2016)
6.	Kadomatsu, Kenji: 2 articles (08/2017 - 01/2016)
7.	Ohgomori, Tomohiro: 2 articles (08/2017 - 01/2016)
8.	Takeuchi, Hideyuki: 2 articles (08/2017 - 01/2016)
9.	Wang, Xiaona: 2 articles (06/2016 - 05/2015)
10.	Llorens, J: 2 articles (05/2013 - 02/2012)

Related Diseases

1.	Demyelinating Diseases (Demyelinating Disease) 03/01/1987 - "This study examined Schwann cell behavior during paranodal demyelination induced by beta,beta'-iminodipropionitrile (IDPN). " 08/01/1981 - "Demyelination in experimental beta, beta'-iminodipropionitrile and hexacarbon neuropathies. " 07/01/1978 - "Centrifugal segmental demyelination extended from the proximal to the distal portion, and onion bulb formation in the extraspinal ventral root occurred following the axonal lesion of the intraspinal ventral root induced by 3,3'-iminodipropionitrile. " 07/01/1978 - "3,3'-Iminodipropionitrile induced centrifugal segmental demyelination and onion bulb formation."
2.	Neuroinflammatory Diseases 09/21/2020 - "In the current study, a rat model of 3,3'-iminodipropionitrile (IDPN)-induced TS was used to explore the regulating effects and mechanisms of NDG on microglia-mediated neuroinflammation. " 08/01/2017 - "We then compared the following pharmacological models - the chronic administration of 3,3'-iminodipropionitrile (IDPN), which models axonal impairment, and the acute administration of lipopolysaccharide (LPS), which is a model of neuroinflammation. " 01/01/2016 - "For the purpose of comparative morphometry, we also analysed two pharmacological disease models using wild-type mice: 3,3'-iminodipropionitrile (IDPN)-induced axonopathy and lipopolysaccharide (LPS)-induced neuroinflammation. "
3.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 06/01/2014 - "In rodents exposed to 3,3'-iminodipropionitrile (IDPN), neurofilaments (NFs) accumulate in swollen proximal axon segments; this also occurs in motor neurons of patients with amyotrophic lateral sclerosis. " 05/01/2013 - "Furthermore, little is known regarding the mechanisms of neurofilamentous axonopathy caused by 3,3'-iminodipropionitrile, an experimental toxin that induces proximal axon swelling that is strikingly similar to that found in early amyotrophic lateral sclerosis. " 02/01/2012 - "Rodents exposed to 3,3'-iminodipropionitrile (IDPN) develop an axonopathy similar to that observed in amyotrophic lateral sclerosis motor neurones, in which neurofilaments accumulate in swollen proximal axon segments. " 08/15/2000 - "Chronic parenteral administration of beta-beta'-iminodipropionitrile (IDPN) in adult female rats induces large neurofilament-rich axonal spheroids (AXS) in spinal motor neurons closely resembling those AXS in early phases of amyotrophic lateral sclerosis. " 08/01/1993 - "Swelling of proximal axon is a morphological similarity between patients with amyotrophic lateral sclerosis (ALS) and beta, beta'-iminodipropionitrile (IDPN)-injected animals. "
4.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 03/01/1993 - "Adult exposure to the neurotoxicant 3,3'-iminodipropionitrile (IDPN), induces a hyperkinetic syndrome consisting of spontaneous head movements, abnormal circling, backward locomotion, and sensory disruption. " 01/01/1975 - "A permanent hyperkinetic syndrome, characterized by excitation, choreiform head and neck movements and circling, which has led to it being called collectively the "ECC-syndrome," is induced in rats by the daily IP administration of beta, beta'-iminodipropionitrile (IDPN), 300 mg/kg, for 7 days. " 01/01/1977 - "Quipazine (5-25 mg.kg-1, s.c.) was given to rats in which a hyperkinetic syndrome had been previously induced by administration of beta,beta'-iminodipropionitrile (IDPN). "
5.	Cognitive Dysfunction 05/06/2015 - "3,3'-Iminodipropionitrile (IDPN), one of the nitrile derivatives inducing neurotoxicity, causes the dyskinetic syndrome and cognitive impairment. " 06/01/2016 - "3,3'-Iminodipropionitrile (IDPN), one of the nitrile derivatives, can induce persistent neurotoxicity, and therefore cause dyskinesia and cognitive impairments. "

Related Drugs and Biologics

1.	Nitriles
2.	Lipopolysaccharides
3.	Apomorphine
4.	Drinking Water
5.	Quipazine
6.	Proteins (Proteins, Gene)
7.	Glycosaminoglycans
8.	Dopamine (Intropin)
9.	gastrodin