12-hydroxy-5,8,10-heptadecatrienoic acid

metabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation

Also Known As:

12-HHT; 12-L-hydroxy-5,8,10-heptadecatrienoic acid; 12-hydroxy-5,8,10-heptadecatrienoic acid, (E,Z,Z)-isomer; 12-hydroxy-5,8,10-heptadecatrienoic acid, (S)-(E,Z,Z)-isomer; 12-hydroxy-5,8,10-heptadecatrienoic acid, (S)-(Z,E,E)-isomer; 12-hydroxy-5,8,10-heptadecatrienoic acid, (S)-isomer; hydroxyheptadecatrienoic acid; 5,8,10-heptadecatrienoic acid, 12-hydroxy-

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - 12-hydroxy-5,8,10-heptadecatrienoic acid: 13

Experts

1.	Yokomizo, Takehiko: 3 articles (10/2017 - 06/2014)
2.	Koga, Tomoaki: 2 articles (10/2017 - 06/2014)
3.	Okuno, Toshiaki: 2 articles (10/2017 - 06/2014)
4.	Cai, Chun: 1 article (11/2017)
5.	Chen, Bin: 1 article (11/2017)
6.	Huang, Qionglin: 1 article (11/2017)
7.	Li, Jian: 1 article (11/2017)
8.	Liu, Huwei: 1 article (11/2017)
9.	Mo, Mingming: 1 article (11/2017)
10.	Shen, Sensen: 1 article (11/2017)

Related Diseases

1.	Inflammation (Inflammations) 06/30/2012 - "Considering the critical role of IL-6 in cutaneous inflammation, our findings provide the basis for the application of 12-HHT as a potential anti-inflammatory therapeutic agent in UV-induced skin diseases." 06/30/2012 - "In this study, we found that 12-HHT treatment in HaCaT cells remarkably down-regulated the ultraviolet B (UVB) irradiation-induced synthesis of interleukin-6 (IL-6), a pro-inflammatory cytokine associated with cutaneous inflammation. "
2.	Wounds and Injuries (Trauma) 10/16/2017 - "12-HHT accelerated wound closure both in BLT2-transfected corneal cell line and human primary corneal epithelial cells. " 06/02/2014 - "Time heals all wounds--but 12-HHT is faster." 06/02/2014 - "12-HHT accumulated in the wound fluid in mice, and BLT2-deficient mice exhibited impaired re-epithelialization and delayed wound closure after skin punching. " 06/02/2014 - "Aspirin administration reduced 12-HHT production and resulted in delayed wound closure in wild-type mice, which was abrogated in BLT2-deficient mice. "
3.	Skin Diseases (Skin Disease) 06/30/2012 - "Considering the critical role of IL-6 in cutaneous inflammation, our findings provide the basis for the application of 12-HHT as a potential anti-inflammatory therapeutic agent in UV-induced skin diseases." 01/01/2016 - "Furthermore, 12-HHT induced actin polymerization with phosphorylation of myosin phosphatase target subunit 1. These results suggest that the ligation of BLT2 protects permeability barrier function by enhancing cell-cell contact, even under low-calcium conditions, and indicate that a BLT2 agonist could be a novel therapeutic target for barrier-disrupted skin diseases."
4.	Corneal Injuries 10/16/2017 - "We hypothesized that NSAID-dependent corneal damage is caused by reduced production of 12-HHT. "
5.	Atherosclerotic Plaque (Atheroma) 01/01/2013 - "Thus, CYP2S1 generates 12-HHT and is a novel regulator of macrophage function that is expressed in classical inflammatory macrophages, and can be found in murine and human atherosclerotic plaques."

Related Drugs and Biologics

1.	Cytokines
2.	Interleukin-6 (Interleukin 6)
3.	Prostaglandin D2
4.	Thromboxane B2
5.	Myosin-Light-Chain Phosphatase
6.	Arachidonic Acid (Vitamin F)
7.	Eicosanoids
8.	Dinoprost
9.	Thromboxanes
10.	Thromboxane A2 (A2, Thromboxane)

Related Therapies and Procedures

1.	Ligation
2.	Intradermal Injections