25-hydroxycholesterol

Also Known As:

25-hydroxycholesterol, (3beta)-isomer, 26-(14)C-labeled; 25-hydroxycholesterol, (3beta,20S)-isomer; 5-cholesten-3beta,25-diol; 5-cholestene-3beta,25-diol; cholest-5-ene-3 beta,25-diol

Networked: 150 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McDonald, Jeffrey G: 3 articles (05/2022 - 08/2014)
2.	Tanaka, Arowu R: 3 articles (01/2022 - 01/2013)
3.	Cheng, Genhong: 3 articles (10/2021 - 01/2017)
4.	Ma, Feng: 3 articles (10/2021 - 01/2017)
5.	Sun, Caijun: 3 articles (10/2021 - 01/2018)
6.	Chen, Li: 3 articles (05/2021 - 01/2017)
7.	Lin, Yanliang: 3 articles (05/2021 - 01/2017)
8.	Lv, Yinping: 3 articles (05/2021 - 01/2017)
9.	Wang, Yibing: 3 articles (05/2021 - 01/2017)
10.	Xian, Guozhe: 3 articles (05/2021 - 01/2017)

Related Diseases

1.	Zika Virus Infection 01/01/2017 - "Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in response to ZIKV infection and that its enzymatic product, 25-hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV. " 01/01/2017 - "25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model."
2.	Infections 10/01/2021 - "Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure." 01/01/2019 - "Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol." 01/01/2018 - "Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol." 12/21/2021 - "IMPORTANCE A cholesterol derivative, 25-hydroxycholesterol (25HC), has been demonstrated to inhibit infections from widely different bacteria and viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). " 10/01/2021 - "Cholesterol-25-hydroxylase (CH25H) and its enzymatic product 25-hydroxycholesterol (25HC) exert broadly antiviral activity including inhibiting HIV-1 infection. "
3.	Virus Diseases (Viral Diseases) 01/01/2022 - "IMPORTANCE The enzymatic product of CH25H, 25-hydroxycholesterol (25HC), has been previously shown to play a critical role in the blockage of the cell-virus fusion in response to viral infection. " 01/01/2022 - "Recent studies have demonstrated that virus infection, dsRNA, dsDNA, interferons, LPS, and 25-hydroxycholesterol (25-HC) can increase RIG-1 expression in ECs and propagate anti-viral response. " 11/01/2020 - "25-Hydroxycholesterol (25HC), one of the most important oxysterol molecules, can be used by cells to fight bacterial and viral infections but the mechanism that defines its biological effects are unknown. " 12/01/2018 - "Production of 25-hydroxycholesterol (25HC), a potent inhibitor of viral infection, is catalyzed by cholesterol 25-hydroxylase (CH25H). " 12/21/2022 - "This study reports that 25-hydroxycholesterol (25HC) significantly restricted PDCoV infection through modulation of cholesterol metabolism, and we identified that lipid droplets play important roles in interferon response against virus infection. "
4.	Atherosclerotic Plaque (Atheroma) 02/01/2015 - "24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54-84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45-78 years, controls). " 09/15/2006 - "In the present study, we investigated the cytotoxic effects of 7beta-hydroxycholesterol (7betaOH), 7-ketocholesterol (7keto), 25-hydroxycholesterol (25OH), and 27-hydroxycholesterol (27OH) on U937 monocytic cells, both individually and in atheroma-relevant mixtures mimicking the oxysterol composition reported in human atheroma lesions. " 01/01/2022 - " symptomatic subjects´ atherosclerotic plaques, an increased amount of cholesterol (3x) and oxysterols [7 α-hydroxycholesterol (1.4x); 7 β-hydroxycholesterol (1.2x); 25-hydroxycholesterol (1.3x); 24-hydroxycholesterol (2.7x), and 27-hydroxycholesterol, (1.15x)], with exception to 7 ketocholesterol, were found in comparison to asymptomatic individuals. " 03/01/2007 - "As products of cholesterol oxidation (oxysterols) accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery, we investigated the potential of 7-ketocholesterol (7-KC), 7beta-hydroxycholesterol (7beta-HC) and 25-hydroxycholesterol (25-HC) to stimulate inflammatory signalling via the lipid-recognising TLRs 1, 2, 4 and 6. Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not IkappaBalpha degradation or tumour necrosis factor-alpha release from monocytic THP-1 cells. "
5.	Mastocytoma 09/01/1994 - "The objective of this study was to investigate the effects of oxysterols (OS), namely 5 alpha-hydroxy-6-ketocholestanol, 6-ketocholestanol and 25-hydroxycholesterol, on specific cell-mediated cytotoxicity by C57BL/6 spleen cells against P815-X2 (a DBA/2 mastocytoma) target cells. " 08/01/1984 - "The mechanism whereby 25-hydroxycholesterol, an inhibitor of the synthesis of cholesterol, depresses DNA synthesis in cycling P815 mastocytoma cells was investigated. "

Related Drugs and Biologics

1.	Oxysterols
2.	Interferons
3.	Cholesterol
4.	7-ketocholesterol
5.	Antiviral Agents (Antivirals)
6.	27-hydroxycholesterol
7.	Lipids
8.	cholest-5-en-3 beta,7 alpha-diol
9.	Proteins (Proteins, Gene)
10.	Lanosterol

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention