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homocysteine thiolactone

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RN given refers to cpd without isomeric designation

Also Known As:

Hcy-thiolactone; homocysteine thiolactone hydrochloride; homocysteine thiolactone hydrochloride, (+-)-isomer; homocysteine thiolactone perchlorate salt; homocysteine thiolactone perchlorate, (S)-isomer; homocysteine thiolactone, (+-)-isomer; homocysteine thiolactone, (S)-isomer; homocysteine-thiolactone; 3-aminodihydro-2(3H)-thiophenone

Networked: 125 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jakubowski, Hieronim: 21 articles (07/2015 - 02/2005)
2.	Djuric, Dragan: 6 articles (01/2013 - 01/2009)
3.	Stanojlović, Olivera: 6 articles (01/2013 - 05/2009)
4.	Jakubowski, H: 6 articles (12/2008 - 02/2000)
5.	Hrncić, Dragan: 5 articles (01/2013 - 01/2009)
6.	Rasić-Marković, Aleksandra: 5 articles (01/2013 - 01/2009)
7.	Djuric, D: 4 articles (06/2015 - 05/2014)
8.	Macut, Djuro: 4 articles (01/2012 - 05/2009)
9.	Macut, D: 3 articles (06/2014 - 03/2011)
10.	Marczak, Lukasz: 3 articles (01/2014 - 10/2010)

Related Diseases

1.	Seizures (Seizure) 06/01/2014 - "The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. " 01/01/2013 - "The aim of the present study was to investigate the effects of paradoxical sleep deprivation on homocysteine thiolactone (H)-induced seizures in rats, a model of generalized seizures. " 05/01/2009 - "Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study." 01/01/2014 - "The inactivation of the Pon1 gene in mice causes the accumulation of Hcy-thiolactone in the brain and increases the susceptibility to Hcy-thiolactone-induced seizures. " 01/01/2014 - "The inactivation of the Blmh gene in mice causes accumulation of Hcy-thiolactone in the brain and increases susceptibility to Hcy-thiolactone-induced seizures. "
2.	Atherosclerosis 06/01/2006 - "This article reviews recent studies of Hcy-thiolactone and N-Hcy-protein in the human body, including their roles in autoimmune response, cellular toxicity, and atherosclerosis. " 01/01/2011 - "Recently it has been suggested that a physiological substrate of serum PON1 is homocysteine thiolactone which is a putative risk factor in atherosclerosis. " 01/01/2002 - "Prevention of homocysteine thiolactone induced atherogenesis in rats." 07/07/2000 - "Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosis." 04/01/1999 - "Homocysteine thiolactone is a cyclic thioester that is implicated in the development of atherosclerosis. "
3.	Hyperhomocysteinemia 06/01/2015 - "The maximal cardiotoxic effect of homocysteine thiolactone was detected at 1 × 10⁻³ M, which corresponds to severe hyperhomocysteinemia. " 07/01/2012 - "Hyperhomocysteinemia was induced using a reduced form of Hcys (at final dose of 0.1mM) and the most reactive form of Hcys - its cyclic thioester, homocysteine thiolactone (HTL, 1 μM). " 01/01/2011 - "We induced hyperhomocysteinemia using a reduced form of Hcys (final dose, 0.1 mM) and the most reactive form of Hcys, its cyclic thioester, homocysteine thiolactone (HTL, 1 µM). " 12/01/2009 - "Homocysteinylation is a post-translational protein modification which involves homocysteine-thiolactone and may be responsible for many pathophysiological changes secondary to hyperhomocysteinemia. " 10/01/2009 - "Hyperhomocysteinemia induced by feeding rats diets rich in DL-homocysteine thiolactone promotes alterations on carotid reactivity independent of arterial structure."
4.	Arteriosclerosis 01/01/1988 - "The findings support the previous demonstration of abnormal homocysteine thiolactone metabolism in arteriosclerosis and cancer." 01/01/1988 - "Homocysteine thiolactone in arteriosclerosis and cancer." 01/01/2003 - "This facile method for quantitation of homocysteine thiolactone opens the way for more detailed clinical studies of its potential role in homocysteine-induced arteriosclerosis and vaso-occlusive disease." 02/01/1989 - "Homocysteinemia and arteriosclerosis: failure to isolate homocysteine thiolactone from plasma and lipoproteins." 05/01/1975 - "The growth disorders associated with homocystinuria, including arteriosclerosis and accelerated growth, are believed to result from increased conversion of methionine to homocysteine thiolactone and homocysteic acid."
5.	Carcinoma (Carcinomatosis) 09/01/1963 - "[STUDY OF THE RADIOPROTECTIVE ACTION OF HOMOCYSTEINE-THIOLACTONE ON THE CELLS OF EHRLICH'S ASCITES CARCINOMA]."

Related Drugs and Biologics

1.	Adenosine
2.	Homocysteine
3.	Folic Acid (Vitamin M)
4.	NG-Nitroarginine Methyl Ester (L-NAME)
5.	Dizocilpine Maleate (Dizocilpine)
6.	Superoxides (Superoxide)
7.	Arginine (L-Arginine)
8.	thioretinaco
9.	N-homocysteine thiolactonyl retinamido cobalamin
10.	N-homocysteine thiolactonyl retinamide

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Microspheres (Microsphere)
3.	Injections