geniposide

01/01/2017 - "As a very promising natural agent, geniposide may be a future therapeutic for stroke patients."
03/14/2014 - "Stroke improved the absorption of geniposide in XNJ. "
01/01/2014 - "Cognition is improved in stroke patients treated with herbal medicine active components, Geniposide (GP) and Geniposide Rg1 (GRg1) (together, called TLJN). "
01/01/2017 - "However, it is still unclear whether and how geniposide affects neuronal insult under experimental stroke. "
01/01/2022 - "Findings have shown that the decoction of Panax notoginseng and Gardenia jasminoides Ellis enhances memory functions in patients with stroke, and their main components, Panax notoginseng saponins (PNS) and geniposide (GP), improved memory abilities in experimental AD models. "

10/05/2023 - "Geniposide ameliorates colitis by activation of Nrf2/ARE signaling, while preventing colonic redox imbalance and inflammatory damage, indicating that geniposide can be considered as a promising lead compound for the treatment of colitis."
01/01/2020 - "Herein, in this study, we aimed to uncover the systematic understanding of the mechanism and effects of geniposide in ameliorating inflammatory responses in colitis. "
05/01/2017 - "The present study aimed to investigate the effects of geniposide on experimental rat colitis and to reveal the related mechanisms. "
10/05/2023 - "The protective effect of geniposide against colitis was evaluated by histopathologic observation and biochemical analysis of colonic tissues in DSS-induced colitis mice. "
01/01/2020 - "The activation of NLRP3 attenuated the anti-inflammatory effects of geniposide in colitis. "

07/01/2017 - "Protective Effects of Geniposide on Hepatic Ischemia/Reperfusion Injury."
09/01/2023 - "Protective effect and possible mechanisms of geniposide for ischemia-reperfusion injury: A systematic review with meta-analysis and network pharmacology of preclinical evidence."
01/01/2019 - "This study implied that Geniposide has a protective effect on myocardial ischemia reperfusion injury in diabetic rats, and its mechanism is associated with activating NRF2/HO-1 signaling pathway to suppress oxidative stress."
09/08/2023 - "Pretreatment with geniposide mitigates myocardial ischemia/reperfusion injury by modulating inflammatory response through TLR4/NF-κB pathway."
08/01/2020 - "Inhibition of autophagy by geniposide protects against myocardial ischemia/reperfusion injury."

01/01/2019 - "The aim of this study was to investigate the mechanisms of geniposide in alleviating inflammation and thereby attenuating the development of AS. "
11/01/2023 - "Geniposide is well-known for its anti-inflammation and anti-apoptosis in several pathological tissues. "
10/05/2023 - "Mechanistically, geniposide could bind to KEAP1, thereby disrupting the interaction between KEAP1 and Nrf2, preventing Nrf2 from degradation and activating the Nrf2/ARE signaling pathway, ultimately suppressing the onset of inflammation caused by redox imbalance. "
10/05/2023 - "ML385, a specific Nrf2 inhibitor, abolished the protective effect of geniposide against LPS-induced inflammation. "
09/01/2023 - "The review found that geniposide protects against I/R injury by inhibiting apoptosis, oxidation, inflammation and improvement of autophagy and mitochondrial respiration, which is consistent with the results of the network pharmacology screening. "

02/01/2017 - "Notably, geniposide enhanced the efficacy of DOX against MG63/DOX cancer cell-derived xenografts in nude mice. "
01/01/2018 - "The results of this study show thatLcS enhanced the antiproliferative effect of geniposide in HSC-3 cancer cells."
12/01/2022 - "Cell viability assay revealed that geniposide treatment significantly suppressed the proliferation of all three cancer cell lines. "
01/01/2022 - "Retraction notice to "Geniposide plays anti-tumor effects by down-regulation of microRNA-224 in HepG2 and Huh7 cell lines" [Experimental and Molecular Pathology 112 (2020) 104349]."
01/01/2020 - "Geniposide plays anti-tumor effects by down-regulation of microRNA-224 in HepG2 and Huh7 cell lines."