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gallein

do not confuse with gallin; structure

Also Known As:

3',4',5',6'-tetrahydroxyfluoran

Networked: 17 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - gallein: 17

Experts

1.	Blaxall, Burns C: 3 articles (01/2017 - 06/2014)
2.	Kamal, Fadia A: 2 articles (01/2017 - 06/2014)
3.	Travers, Joshua G: 2 articles (01/2017 - 06/2014)
4.	Smrcka, Alan V: 2 articles (01/2016 - 06/2014)
5.	Bushinsky, David A: 1 article (10/2021)
6.	Krieger, Nancy S: 1 article (10/2021)
7.	Baijal, Kanchi: 1 article (01/2021)
8.	Condés-Lara, Miguel: 1 article (01/2021)
9.	Downey, Michael: 1 article (01/2021)
10.	Espinosa de Los Monteros-Zúñiga, Antonio: 1 article (01/2021)

Related Diseases

1.	Myocarditis (Carditis) 01/01/2018 - "We investigated the efficacy of a small molecule Gβγ inhibitor, gallein, in a clinically relevant, experimental autoimmune myocarditis (EAM) model of HF as well as in human macrophage phenotypes in vitro. "
2.	Respiratory Insufficiency (Respiratory Failure) 04/01/2013 - "In contrast, the dose-dependent respiratory depression and hyperlocomotion induced by morphine were not potentiated by gallein pretreatment. " 01/01/2023 - "We showed that inhibition of βγ G-proteins using gallein perfused in the brainstem circuits regulating respiratory depression by opioid drugs results in complete reversal of respiratory depression. "
3.	Polyps 02/16/2023 - "Rothia dentocariosa can directly change extracellular Pi and accumulate intracellular polyP, but the mechanism is attenuated by gallein and NaF." 01/01/2021 - "In this commentary, we discuss the impact of this discovery, outline potential challenges of implementing gallein use in the clinic, and describe how gallein will serve as a fantastic new tool to further fundamental PPK and polyP research in bacteria." 02/16/2023 - "There was a corresponding polyP synthesis decrease of 73.2% (P < 0.0001) from gallein and 83.1% (P < 0.0001) from fluoride. " 02/16/2023 - "To test the effect of potential inhibitors of polyP kinases on Rothia dentocariosa, gallein (0, 25, 50, and 100 μM) and fluoride (0, 50, and 100 ppm) were added to R. "
4.	Ischemia 10/01/2014 - "Gallein treatment significantly reduced (P < 0.05) the number of proliferating cell nuclear antigen-positive tubular epithelial cells at 24 hours after the ischemia-reperfusion phase in vivo. " 01/01/2017 - "To investigate a direct effect of gallein on the kidney, we used a bilateral ischemia-reperfusion AKI mouse model, in which gallein attenuated renal dysfunction, tissue damage, fibrosis, inflammation, and ET system activation. "
5.	Inflammation (Inflammations) 01/01/2016 - "Finally, gallein treatment dramatically inhibited kidney inflammation, prevented glomerular damage, and decreased proteinuria. " 01/01/2016 - "Mechanistically, gallein inhibited immune cell migration and signaling in response to chemokines in vitro, which suggests that its mechanisms of action in vivo are inhibition of migration of immune cells to sites of inflammation and inhibition of immune cell maturation. " 01/01/2017 - "To investigate a direct effect of gallein on the kidney, we used a bilateral ischemia-reperfusion AKI mouse model, in which gallein attenuated renal dysfunction, tissue damage, fibrosis, inflammation, and ET system activation. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Intraperitoneal Injections
3.	Analgesia