factor 420 (F(420))

isolated from Methanobacterium strain MOH; mol Wt. about 630; can serve as electron carrier; involved in NADP-linked hydrogenase system

Also Known As:

F(420); 7,8-didemethyl-8-hydroxy-5-deazariboflavin; 8-HDF cpd; 8-hydroxy-5-deazaflavin; D-Ribitol, 1-deoxy-1-(3,4-dihydro-8-hydroxy-2,4-dioxopyrimido(4,5-b)quinolin-10(2H)-yl)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bouamra, Omar: 1 article (01/2022)
2.	Fenwick, Rob: 1 article (01/2022)
3.	Heidari, Shirin: 1 article (01/2022)
4.	Nutbeam, Tim: 1 article (01/2022)
5.	Smith, Jason: 1 article (01/2022)
6.	Stassen, Willem: 1 article (01/2022)
7.	Weekes, Lauren: 1 article (01/2022)
8.	Mukhopadhyay, Biswarup: 1 article (04/2009)
9.	Purwantini, Endang: 1 article (04/2009)
10.	Baker, Edward N: 1 article (06/2008)

Related Diseases

1.	Tuberculosis (Tuberculoses) 04/14/2009 - "tuberculosis, which either did not produce or could not reduce F(420), was approximately 4-fold more sensitive to NO(2) than the wild-type strain. " 06/20/2008 - "tuberculosis FGD1 has been determined by x-ray crystallography both in its apo state and in complex with F(420) and citrate at resolutions of 1.90 and 1.95 A(,) respectively. " 06/20/2008 - "In Mtb, the F(420)-dependent glucose-6-phosphate dehydrogenase FGD1 provides reduced F(420) for the in vivo activation of the nitroimidazopyran prodrug PA-824, currently being developed for anti-tuberculosis therapy against both replicating and persistent bacteria. "
2.	Wounds and Injuries (Trauma) 01/01/2022 - "Female patients had more injuries to the pelvis (F 420 (14.6%), M 475 (9.7%); p<0.0001) and spine (F 359 (12.5%), M 485 (9.9%); p=0.001). "

Related Drugs and Biologics

1.	Citric Acid (Citrate)
2.	Prodrugs
3.	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)
4.	pretomanid

Related Therapies and Procedures

1.	Therapeutics