esculetin

01/22/2023 - "In conclusion, this novel study proves that esculetin exerts in vitro antitumor effects by inducing apoptosis and cell cycle arrest in canine mammary gland tumors."
01/22/2023 - "In this study, we explore the anticancer effects of esculetin against CMT-U27 and CF41.mg canine mammary gland tumor cells. "
01/01/2011 - "Esculetin, a phenolic compound, has been shown to inhibit the growth of colon tumors in animal studies. "
01/31/2023 - "Antiovarian cancer mechanism of esculetin: inducing G0/G1 arrest and apoptosis via JAK2/STAT3 signalling pathway."
08/01/2022 - "With respect to apoptosis regulation, esculetin significantly decreased the proliferation of tumor cells in a xenograft model (100 mg/kg/day) for 18 days. "

01/01/2018 - "In this study, we aimed to investigate the effects of esculetin on psoriatic skin inflammation in a mouse model and explored the potential molecular mechanisms underlying its action. "
01/01/2023 - "The experimental results revealed that esculetin treatment mitigated pathological damage of intestinal tissues, reduced serum DAO level, ameliorated inflammation, oxidative stress and apoptosis and promoted autophagy in intestinal I/R rats. "
04/24/2022 - "Esculetin is a bioactive compound of medicinal herb Hydrangea paniculata, and has showed anti-oxidation and anti-inflammation bioactivities. "
01/01/2021 - "Esculetin can reduce liver injury through the mitigation of oxidative burden, inflammation, and neutrophil infiltration and also exerts hepatoprotective effects against ALF."
08/01/2020 - "Aesculetin maybe a promising agent counteracting macrophage-mediated inflammation-associated pulmonary disorders."

11/01/2023 - "Therapeutic efficacy of mitochondria-targeted esculetin in the improvement of NAFLD-NASH via modulating AMPK-SIRT1 axis."
08/01/2017 - "Esculetin ameliorates hepatic fibrosis in high fat diet induced non-alcoholic fatty liver disease by regulation of FoxO1 mediated pathway."
08/01/2017 - "This study demonstrates the efficiency of Esculetin in improving liver fibrosis in HFD induced NAFLD."
01/13/2023 - "Esculetin (ESC) is an active compound discovered in a variety of natural products that modulates a wide range of metabolic diseases and is a potential drug for the treatment of NAFLD. "
11/01/2023 - "Recently, we synthesized a novel mitochondria-targeted esculetin (Mito-Esc) and investigated its dose-response therapeutic efficacy in mitigating high-fat diet (HFD)-induced NAFLD and NASH in Apoe-/- mice. "

10/20/2022 - "Esculetin has an immense antioxidative potential thereby alleviating arthritis, diabetes, malignancies, and hepatic disorders. "
01/01/2016 - "Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis."
01/01/2016 - "Because esculetin decreases the LTB4 level in plasma of rats in adjuvant-induced arthritis, it may also be considered as an attractive drug candidate for patients with rheumatoid arthritis."
01/01/2016 - "Five-day treatment with esculetin in adjuvant-induced arthritis rats decreases the LTB4 level to a level comparable with rats without inflammation (284 ±23 pg/ml, p < 0.01). "
10/20/2022 - "Leukotriene B4 synthesis, NF-κB and MPAK pathway activation, and inflammatory cytokine production are the main causes of bone and joint deterioration in arthritis, whereas esculetin treatment reverses these factors and relieves the disease condition. "

07/01/2019 - "These results indicate that esculetin inhibits the growth of leukemia cells and hence may prove beneficial for treating leukemia."
07/01/2019 - "The present study was designed to investigate the anticancer effects of esculetin against the human leukemia HL-60 cells. "
10/02/2017 - "These results contribute to the study of the antitumor properties of esculetin by regulation of redox balance in leukemia cells."
03/01/2008 - "In the present study, we used human leukemia cells to gain further insight into the mechanism of esculetin-induced anti-proliferative action and apoptosis. "
03/23/2001 - "In the present study, esculetin was found to inhibit the survival of human promyelocytic leukemia HL-60 cells in a concentration-dependent and time-dependent manner. "