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erythritol anhydride (butanedione)

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difunctional alkylating agent; RN given refers to cpd with unspecified isomeric designation; structure

Also Known As:

butanedione; diepoxybutane; 1,2-3,4-diepoxybutane; 2,2'-bioxirane; butadiene bisoxide; butadiene diepoxide; butadiene dioxide; erythritol anhydride, ((R*,R*)-(+-))-isomer; erythritol anhydride, (R*,S*)-isomer; erythritol anhydride, (R-(R*,R*))-isomer; erythritol anhydride, (S-(R*,R*))-isomer

Networked: 133 relevant articles (5 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Ethers: 174
  - Cyclic Ethers: 4
    - Epoxy Compounds: 136
      - erythritol anhydride: 133

Experts

1.	Porto, Beatriz: 6 articles (06/2013 - 04/2003)
2.	Auerbach, Arleen D: 4 articles (01/2015 - 07/2003)
3.	Törnqvist, Margareta: 3 articles (12/2014 - 06/2004)
4.	Olson, Susan B: 3 articles (01/2014 - 07/2003)
5.	Carvalho, Félix: 3 articles (06/2013 - 01/2006)
6.	Ponte, Filipa: 3 articles (06/2013 - 05/2011)
7.	Pagano, Giovanni: 2 articles (07/2015 - 11/2003)
8.	Sousa, Rosa: 2 articles (06/2013 - 05/2011)
9.	Barbot, José: 2 articles (06/2013 - 05/2011)
10.	Gonçalves, Cristina: 2 articles (06/2013 - 05/2011)

Related Diseases

1.	Fanconi Anemia (Fanconi's Anemia) 03/01/2009 - "The objective of the present study was to determine the efficacy of this method for the diagnosis of 84 Brazilian patients with Fanconi anemia, all of whom tested positive for the diepoxybutane test, and 98 healthy controls. " 05/01/1983 - "Fanconi's anemia: a cytogenetic study on lymphocyte and bone marrow cultures utilizing 1,2:3,4-diepoxybutane." 01/01/2015 - "Diagnosis of fanconi anemia by diepoxybutane analysis." 12/01/2011 - "Diagnosis of Fanconi's Anemia by Diepoxybutane Analysis in Children from Serbia." 10/28/2011 - "The biotransformation and oxidative stress may contribute to 1,2:3,4-diepoxybutane (DEB)-induced toxicity to human lymphocytes of Fanconi Anemia (FA) patients. "
2.	Chromosome Breakage 05/01/1982 - "During the present remission her cultured lymphocytes, bone marrow cells, and fibroblasts showed increased "spontaneous" chromosome breakage as well as enhanced sensitivity to the clastogenic effect of the difunctional alkylating agent diepoxybutane (DEB), features characteristic of FA. " 07/31/2009 - "Although this highly variable phenotype makes accurate diagnosis on the basis of clinical manifestations difficult in some patients, laboratory study of chromosomal breakage induced by diepoxybutane (DEB) or other crosslinking agents provides a unique cellular marker for the diagnosis of the disorder either prenatally or postnatally. " 04/01/1992 - "There was no evidence for increased baseline or diepoxybutane (DEB)-induced chromosomal breakage in either twin when the studies were repeated in Denver as well as in New York. " 12/01/2010 - "Normal red blood cells partially decrease diepoxybutane-induced chromosome breakage in cultured lymphocytes from Fanconi anaemia patients." 05/01/2010 - "For the stimulation of chromosomal breakages, diepoxybutane was used (DEB test). "
3.	Hypersensitivity (Allergy) 01/01/2005 - "The gold-standard screening test for FA is based on the characteristic hypersensitivity of FA cells to the crosslinking agents, such as mitomicin C or diepoxybutane. " 04/01/2014 - "Specific hypersensitivity of its cells to chemical agents, such as diepoxybutane (DEB), was used as a part of screening among patients with clinical suspicion of FA. " 05/01/2005 - "We present the results obtained after screening 80 non-consanguineous FA patients referred from all regions of Brazil with a clinical diagnosis of FA supported by cellular hypersensitivity to diepoxybutane. " 01/01/2004 - "Hypersensitivity of FA cells to the clastogenic effect of diepoxybutane (DEB) provides a unique marker for the diagnosis before the beginning of hematological manifestations. " 07/01/1997 - "There was no direct correlation between the degree of cellular hypersensitivity to the clastogenic effect of diepoxybutane and severity of clinical phenotype. "
4.	Chromosome Fragility 10/01/1988 - "Spontaneous and diepoxybutane-induced chromosomal fragility was within the range of normal cells but was elevated through induction with 4-nitroquinoline-oxide. " 04/01/2011 - "Chromosome fragility induced by DNA interstrand crosslink (ICL)-inducing agents such as diepoxybutane (DEB) or mitomycin C (MMC) is the 'gold standard' test for the diagnosis of FA. "
5.	Myeloid Leukemia (Leukemia, Myelocytic) 07/01/2003 - "Unlike the lymphoblasts, this myeloid leukemia cell line (UoC-M1) was hypersensitive to mitomycin-C (MMC) and diepoxybutane (DEB) and exhibited a marked decrease in nuclear FANCA, FANCG, and FANCD2-L. "

Related Drugs and Biologics

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4.	Bleomycin (Blenoxane)
5.	Triaziquone
6.	arsenite
7.	Butadienes
8.	Alkylating Agents
9.	Mutagens
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Transplants (Transplant)
3.	Intraperitoneal Injections
4.	Drug Therapy (Chemotherapy)