1,2-dibromo-3-chloropropane (DBCP)

09/01/1983 - "Animal studies in the early 1960s revealed hepatic and renal effects and testicular atrophy in DBCP-treated rates. "
08/01/1983 - "DBCP reduced the relative weights of the testis and epididymis in a progressive manner and produced dose-dependent seminiferous tubular atrophy within 12 days of treatment. "
08/01/1983 - "DBCP also caused a reversible vacuolization of the tubular epithelium in the caput epididymis, progressive testicular atrophy, and a reduction of cauda epididymal sperm concentration. "
08/21/1981 - "Tests on laboratory animals have indicated that DBCP has an adverse effect on spermatogenesis and leads to testicular atrophy. "
07/01/1988 - "The fact that testicular DNA damage of DBCP and its deuterated and methylated analogs paralleled their ability to cause testicular necrosis and atrophy makes measurement of DNA damage a very useful correlate in mechanistic studies of DBCP-induced testicular cell death."

04/01/1990 - "Extensive renal tubular necrosis was observed in rats 48 hr after a single intraperitoneal administration (21-170 mumol/kg) of DBCP. "
10/02/1989 - "Thus, induction of DNA damage correlates with the relative susceptibilities of the species towards DBCP-induced testicular necrosis. "
07/01/1988 - "Testicular necrosis and DNA damage caused by deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat."
12/01/1987 - "All of the six deuterated analogs tested at 340 mumol/kg, including the perdeutero compound, failed to significantly alter the kidney necrosis observed at 48 hr compared to DBCP. "
12/01/1987 - "Renal necrosis and DNA damage caused by selectively deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat."

07/20/2002 - "An interventional trial to enhance coping and reduce stress levels may help to decrease the risk for breast cancer onset in DBCP."
07/20/2002 - "This may contribute to the increased risk of DBCP to develop breast cancer. "
07/20/2002 - "DBCP who are aware of their increased risk of developing breast cancer may suffer from high emotional distress. "
04/01/1997 - "This paper discusses breast cancer patterns in Hawaii in the context of documented episodes of exposure to two endocrine-disrupting chemicals, chlordane/heptachlor and 1,2-dibromo-3-chloropropane (DBCP), at levels that sometimes exceeded federal standards by several orders of magnitude. "

01/01/2005 - "While case-control, cohort and ecological epidemiology studies have not found significant, positive associations between DBCP exposure and cancer in exposed populations, these studies have numerous limitations including small numbers of participants, a lack of control for confounding factors, lack of exposure information on DBCP and other chemicals and short follow-up times. "
01/01/2005 - "Few studies have been conducted to assess whether DBCP workplace or drinking water exposures affect cancer risk in humans. "
01/01/2005 - "In this review, we present a critical evaluation of the available scientific literature on the potential for DBCP to affect cancer risk, including the results of animal cancer bioassays, human epidemiological studies and in vitro and in vivo genotoxicity studies. "
09/01/1983 - "A later study linked DBCP to nasal cavity tumors in rats. "
01/01/2005 - "Although high mortality rates in both rat and mouse bioassays limited the ability to detect tumors late in life, the induction of a variety of tumors by multiple routes of exposure in two rodent species provides clear evidence of a DBCP tumorigenic response. "

01/01/1981 - "Recovery from severe oligospermia after exposure to dibromochloropropane."
05/01/2003 - "In this study we characterized an animal model, in which four daily injections of DBCP produced prolonged oligospermia in LBNF(1) rats without any indication of recovery. "
04/01/1999 - "Analyzing information in this database, the authors found that, after a median exposure to DBCP of three years, 64.3% of these men overall, and 90.1% of men studied from the Philippines, had azoospermia or oligospermia. "
04/01/1999 - "Azoospermia and oligospermia among a large cohort of DBCP applicators in 12 countries."
01/01/1988 - "It is concluded that paternal exposure to DBCP, severe enough to cause azoospermia or oligozoospermia, did not increase the rate of congenital malformations or of impaired health status of offspring conceived during or after exposure."