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2,6-diaminopurine

RN given refers to parent cpd

Also Known As:

2,6-diaminopurine sulfate; 2-aminoadenine

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        2-Aminopurine: 31
        2,6-diaminopurine: 13

Experts

1.	Costantino, Gabriele: 1 article (01/2018)
2.	Crespan, Emmanuele: 1 article (01/2018)
3.	Kaptein, Suzanne J F: 1 article (01/2018)
4.	Maga, Giovanni: 1 article (01/2018)
5.	Neyts, Johan: 1 article (01/2018)
6.	Radi, Marco: 1 article (01/2018)
7.	Rivera, Jorge I Armijos: 1 article (01/2018)
8.	Vincetti, Paolo: 1 article (01/2018)
9.	Holy, A: 1 article (05/2001)
10.	Mandys, V: 1 article (05/2001)

Related Diseases

1.	Leukemia 01/01/1949 - "Preliminary studies on the effect of 2,6-diaminopurine on transplanted mouse leukemia." 05/01/1951 - "The effects of the folic acid antagonists and 2,6-diaminopurine on neoplastic disease, with special reference to acute leukemia." 04/01/1951 - "A comparison of the effects of 4-amino-N10-methyl-pteroylglutamic acid and 2,6-diaminopurine upon sensitive and resistant sublines of a strain of mouse leukemia."
2.	Neoplasms (Cancer) 05/01/2001 - "Therefore, these acyclic nucleoside phosphonates substituted at the 6-position of 2,6-diaminopurine ring do not seem to be promising drugs for the treatment of haematological malignancies." 06/01/1996 - "Based on the powerful virostatic potency and cytostatic activity of adenine, 2,6-diaminopurine, and guanine derivatives of acyclic phosphonate nucleotide analog (S)-1-(3-hydroxy-2-phosphonomethoxypropyl) and 9-(2-phosphonomethoxyethyl) series, we examined the inhibitory potencies of their diphosphates [(S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine diphosphate (HPMPApp), 9-(2-phosphonomethoxyethyl)adenine diphosphate, 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine diphosphate (PMEDAPpp), and 9-(2-phosphonomethoxyethyl)guanine diphosphate, analogs of nucleoside 5'-triphosphates] toward cellular DNA polymerases alpha, delta, and epsilon (isolated from tumors of T cell spontaneous acute lymphoblastic leukemia in Sprague-Dawley inbred rats). "
3.	Tetraploidy 11/01/1988 - "Aneuploid and tetraploid cells and variants resistant to 10 micrograms/ml of 2,6-diaminopurine (DAP), which selects for presumptive aprt+/- heterozygotes in the untreated cells, were induced. "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 06/01/1996 - "Based on the powerful virostatic potency and cytostatic activity of adenine, 2,6-diaminopurine, and guanine derivatives of acyclic phosphonate nucleotide analog (S)-1-(3-hydroxy-2-phosphonomethoxypropyl) and 9-(2-phosphonomethoxyethyl) series, we examined the inhibitory potencies of their diphosphates [(S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine diphosphate (HPMPApp), 9-(2-phosphonomethoxyethyl)adenine diphosphate, 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine diphosphate (PMEDAPpp), and 9-(2-phosphonomethoxyethyl)guanine diphosphate, analogs of nucleoside 5'-triphosphates] toward cellular DNA polymerases alpha, delta, and epsilon (isolated from tumors of T cell spontaneous acute lymphoblastic leukemia in Sprague-Dawley inbred rats). "
5.	Psittacosis (Ornithosis) 03/01/1952 - "A number of purine analogues, including benzimidazole, 2,6-diaminopurine, and 8-azaguanine, inhibited the growth of psittacosis virus (6BC) in tissue cultures at concentrations which had no obvious toxic effects on the host tissues. "

Related Drugs and Biologics

1.	Guanine
2.	Organophosphonates (Phosphonates)
3.	Nucleosides
4.	Adenine
5.	adefovir
6.	Cytostatic Agents
7.	Nonsense Codon (Nonsense Mutation)
8.	Foscarnet
9.	Ganciclovir (Cytovene)
10.	Ribavirin (Virazole)