coprostanone

bacterial metabolite of cholesterol via coprostanol; RN given refers to cpd without isomeric designation; structure

Also Known As:

5-alpha-cholestan-3-one; coprostanone, (5alpha)-isomer; coprostanone, (5beta)-isomer

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - coprostanone: 6

Related Diseases

1.	Neoplasms (Cancer) 11/20/2023 - "This study aimed to evaluate the cytotoxicity of metabolites from cholesterol (coprostanol, cholestanol, coprostanone and cholestenone) and β-sitosterol (ethylcoprostanol) on human colon tumor (Caco-2) and non-tumor (CCD-18Co) cells at physiological concentrations (9-300 μM) and exposure time (24 h). "
2.	Colonic Neoplasms (Colon Cancer) 01/01/1981 - "Mean percent degradation of fecal cholesterol to coprostanol, coprostanone, cholestanol, and cholestanone revealed significant decreases in fecal cholesterol conversion in affected and asymptomatic subjects in colon cancer prone families without polyposis (P < 0.001) compared to controls. " 06/01/1977 - "The fecal excretion of cholesterol, coprostanol, coprostanone, total bile acids, deoxycholic acid, lithocholic acid was higher in patients with colon cancer and patients with adenomatous polyps compared to normal American and Japanese controls as well as patients with other digestive diseases. "
3.	Adenomatous Polyps 06/01/1977 - "The fecal excretion of cholesterol, coprostanol, coprostanone, total bile acids, deoxycholic acid, lithocholic acid was higher in patients with colon cancer and patients with adenomatous polyps compared to normal American and Japanese controls as well as patients with other digestive diseases. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2023 - "One such identified mediator, coprostanone, is shown to effectively ameliorating oxidative stress-induced injury in mice with myocardial ischemia/reperfusion injury. "
5.	Reperfusion Injury 01/01/2023 - "One such identified mediator, coprostanone, is shown to effectively ameliorating oxidative stress-induced injury in mice with myocardial ischemia/reperfusion injury. "

Related Drugs and Biologics

1.	Cholesterol
2.	Cholestanol (Coprostanol)
3.	gamma-sitosterol (beta-sitosterol)
4.	Lithocholic Acid
5.	Deoxycholic Acid (Sodium Deoxycholate)
6.	Bile Acids and Salts (Bile Acids)
7.	epicoprostanol
8.	surfomer