coniine

alkaloid isolated from Conium maculatum L.; properties as an analgesics, antineuralgic, & teratogen; RN given refers to parent cpd without isomeric designation; structure

Also Known As:

cicutine; conicine; coniine hydrobromide, (S)-isomer; coniine hydrochloride, (+-)-isomer; coniine hydrochloride, (S)-isomer; coniine, (+-)-isomer; coniine, (S)-isomer; koniin; D-2-(n-propyl)piperidine

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - coniine: 14
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - coniine: 14

Experts

1.	Ilhan, Mustafa: 2 articles (01/2016 - 09/2009)
2.	Iskit, Alper B: 2 articles (01/2016 - 09/2009)
3.	Beyer, Jochen: 2 articles (03/2009 - 05/2007)
4.	Maurer, Hans H: 2 articles (03/2009 - 05/2007)
5.	Basile, Carlo: 1 article (04/2020)
6.	Hotti, Hannu: 1 article (11/2017)
7.	Rischer, Heiko: 1 article (11/2017)
8.	Erkent, Ulkem: 1 article (01/2016)
9.	Onur, Rustu: 1 article (01/2016)
10.	Horowitz, B Zane: 1 article (11/2009)

Related Diseases

1.	Arthrogryposis 12/31/1996 - "We have previously shown that rats are not susceptible and rabbits only weakly susceptible to coniine-induced arthrogryposis. " 04/01/1994 - "In summary, the chick embryo provides a reliable and simple experimental animal model of coniine-induced arthrogryposis. " 04/01/1994 - "However, coniine has failed to produce arthrogryposis in rats or mice and is only weakly teratogenic in rabbits. " 07/01/1993 - "Coniine/CM teratogenicity culminates in production of arthrogryposis. " 07/01/1993 - "Coniine-exposed rabbit litters tended to be affected by arthrogryposis (no bony deformities noted on skeletal exam) more than controls (2/6 vs. 0/9)."
2.	Poisoning 12/16/1989 - "Rhabdomyolysis and acute tubular necrosis in coniine (hemlock) poisoning." 05/01/2007 - "For diagnosis of such poisonings, multianalyte procedures were developed for detection and validated quantification of the toxic alkaloids aconitine, atropine, colchicine, coniine, cytisine, nicotine and its metabolite cotinine, physostigmine, and scopolamine in plasma using LC-APCI-MS and LC-ESI-MS/MS. After mixed-mode solid-phase extraction of 1 ml of plasma, the analytes were separated using a C8 base select separation column and gradient elution (acetonitrile/ammonium formate, pH 3.5). " 03/10/2009 - "This review describes the toxic alkaloids aconitine, atropine, coniine, colchicine, cytisine, dimethyltryptamine, harmine, harmaline, ibogaine, kawain, mescaline, scopolamine, and taxine, which are often involved in fatal and non-fatal poisonings. "
3.	Seizures (Absence Seizure) 04/01/1990 - "At 25 mg coniine/kg body weight, clinical signs were observed only in quails (2/10) and consisted of excitement, depression, hypermetria, seizures, opisthotonos, and flaccid paralysis. " 01/01/2016 - "Toxicity of coniine, an alkaloid of Conium maculatum (poison hemlock), is manifested by characteristic nicotinic clinical signs including excitement, depression, hypermetria, seizures, opisthotonos via postsynaptic nicotinic receptors. "
4.	Rhabdomyolysis 01/01/1991 - "In addition rhabdomyolysis was noted in the 17 subjects poisoned by coniine. " 12/16/1989 - "Rhabdomyolysis and acute tubular necrosis in coniine (hemlock) poisoning."
5.	Paralysis (Palsy) 11/01/2009 - "Conium maculatum is a common weed that causes toxicity by its primary toxin, coniine, which stimulates nicotinic receptors and causes a syndrome of rapidly progressive muscle weakness and paralysis. " 04/01/1990 - "At 25 mg coniine/kg body weight, clinical signs were observed only in quails (2/10) and consisted of excitement, depression, hypermetria, seizures, opisthotonos, and flaccid paralysis. "

Related Drugs and Biologics

1.	Alkaloids
2.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
3.	Scopolamine (Hyoscine)
4.	Colchicine
5.	Atropine
6.	Aconitine
7.	cytisine
8.	Tubocurarine (Tubocurarine Chloride)
9.	Teratogens
10.	Physostigmine