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2-chloroethyl isocyanate
breakdown product of carmustine; inhibits repair of damaged DNA; structure
Also Known As:
NSC 87418; NSC-87418; 2-chloroethylisocyanate
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Isocyanates: 512
2-chloroethyl isocyanate: 4
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
02/17/1988 - "
For example, 2-chloroethyl isocyanate depressed ATP levels in the Morris hepatomas 5123C and 20 under conditions in which there was no significant effect on host liver ATP.
"
09/01/1987 - "
The effects of 2-chloroethylisocyanate, ethylisocyanate and sodium cyanate on the uptake of isotope-labeled thymidine, leucine and H2O were compared in rat liver and hepatomas.
"
2.
Neoplasms (Cancer)
11/01/1999 - "
As analogs of the widely used anti-tumor agents, N-(2-chloroethyl)-N-nitrosoureas, N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates were synthesized by nitration following the reaction of the appropriate amines or alcohols with 2-chloroethyl isocyanate.
"
3.
Hypoxia (Hypoxemia)
10/01/1987 - "
This conclusion is supported by data showing (a) a similar hypoxia-dependent pattern of cytotoxicity in hepatocytes exposed to the BCNU degradation products 2-chloroethyl isocyanate, 2-chloroethanol, and 2-chloroethylamine and (b) little BCNU-induced cytotoxicity, no increase in phosphorylase a activity, and no loss of ATP with 5% O2 in the presence of adenosine (1 mM).
"
Related Drugs and Biologics
1.
Adenosine Triphosphate (ATP)
2.
Thymidine
3.
Phosphorylase a
4.
Leucine (L-Leucine)
5.
Isotopes
6.
Carmustine (FIVB)
7.
Amines
8.
Alcohols
9.
Adenosine (Adenocard)
10.
2-chloroethylamine