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2-chloroethyl isocyanate

breakdown product of carmustine; inhibits repair of damaged DNA; structure

Also Known As:

NSC 87418; NSC-87418; 2-chloroethylisocyanate

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Isocyanates: 512
  - 2-chloroethyl isocyanate: 4

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 02/17/1988 - "For example, 2-chloroethyl isocyanate depressed ATP levels in the Morris hepatomas 5123C and 20 under conditions in which there was no significant effect on host liver ATP. " 09/01/1987 - "The effects of 2-chloroethylisocyanate, ethylisocyanate and sodium cyanate on the uptake of isotope-labeled thymidine, leucine and H2O were compared in rat liver and hepatomas. "
2.	Neoplasms (Cancer) 11/01/1999 - "As analogs of the widely used anti-tumor agents, N-(2-chloroethyl)-N-nitrosoureas, N-(2-chloroethyl)-N-nitroureas and N-(2-chloroethyl)-N-nitrocarbamates were synthesized by nitration following the reaction of the appropriate amines or alcohols with 2-chloroethyl isocyanate. "
3.	Hypoxia (Hypoxemia) 10/01/1987 - "This conclusion is supported by data showing (a) a similar hypoxia-dependent pattern of cytotoxicity in hepatocytes exposed to the BCNU degradation products 2-chloroethyl isocyanate, 2-chloroethanol, and 2-chloroethylamine and (b) little BCNU-induced cytotoxicity, no increase in phosphorylase a activity, and no loss of ATP with 5% O2 in the presence of adenosine (1 mM)."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Thymidine
3.	Phosphorylase a
4.	Leucine (L-Leucine)
5.	Isotopes
6.	Carmustine (FIVB)
7.	Amines
8.	Alcohols
9.	Adenosine (Adenocard)
10.	2-chloroethylamine