cepharanthine

04/01/2009 - "These findings demonstrate that the combination of cepharanthine and S-1 is effective against OSCC and has the potential of being a new therapeutic tool for future treatment of these tumors."
01/01/2020 - "However, cepharanthine monotherapy has insufficient drug efficacy for cancers in animal models and clinical trials. "
10/01/2015 - "Previous studies have demonstrated the antitumor properties of cepharanthine hydrochloride (CH) in several human cancer cells. "
01/01/2014 - "The purpose of the study was to determine the signal transduction mechanism of cepharanthine hydrochloride (CH) on reversing tumor multidrug resistance. "
08/01/2012 - "Tumor xenograft studies demonstrated that the combination of cepharanthine and radiation caused growth inhibition and tumor regression of OSCC tumors in athymic mice; tumor volume was reduced from 765.7 to 226.3 mm3 in HSC2 cells (p<0.01), 391.6 to 43.7 mm3 in HSC3 (p<0.01), and from 572.6 to 174.2 mm3 in HSC4 cells (p<0.01). "

01/01/1999 - "These findings suggest that genetic studies of HLA and HPA can predict the response of idiopathic thrombocytopenic purpura to cepharanthin."
03/01/2017 - "High-dose Cepharanthin for pediatric chronic immune thrombocytopenia in Japan."
12/01/2012 - "[Clinical efficacy of high-dose cepharanthine for idiopathic thrombocytopenic purpura: retrospective multicenter analysis]."
05/01/2001 - "Pharmacological characterization of cepharanthin in chronic idiopathic thrombocytopenic purpura."
01/01/1999 - "Genetic analysis of HLA- and HPA-typing in idiopathic (autoimmune) thrombocytopenic purpura patients treated with cepharanthin."

01/01/1991 - "Administration of Cepharanthin (ceph) resulted in a significant acceleration of the recovery from leukopenia in 5-Gy X-ray irradiated mice. "
08/01/1989 - "These data suggest that the large dose of Cepharanthine contribute to the prevention of leukopenia in patients who are treated with a sufficient amount of anticancer drugs."
09/01/2016 - " this was a retrospective study, cepharanthin was found to be safe and significantly effective for the management of leukopenia caused by radiotherapy. "
09/01/2016 - "The clinical efficacy and safety of cepharanthin for the treatment of radiotherapy-induced leukopenia were reevaluated at multiple institutions.Clinical"
09/01/2016 - "[Clinical Efficacy of Cepharanthin(R)for Radiotherapy-Induced Leukopenia - A Nationwide, Multicenter, and Observational Study]."

11/01/1991 - "The present study indicates that cepharanthin is an effective ROS scavenger, exerting its anti-inflammatory action by reducing the potent ROS species excessively generated in tissues and organs, especially at the sites of inflammation."
12/01/2015 - "Cepharanthine possesses strong anti-inflammation capacity. "
11/01/2011 - "Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation."
01/11/2023 - "Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation."
01/01/2022 - "Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway."

09/01/1988 - "As to the platelet count, cepharanthin group also showed attendant toward earlier recovery of thrombocytopenia than non-cepharanthin group. "
07/01/2012 - "When further chemotherapy was avoided because of the patient's poor general condition, administration of cepharanthine was effective in halting progressive thrombocytopenia due to abnormal immune mechanisms. "
09/01/1988 - "We conclude that the administration of cepharanthin during CAP therapy promotes the recovery from leucopenia and thrombocytopenia."
10/01/2008 - "Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania Cepharantha Hayata, has been used in Japan for treating patients with radiation-induced leucopenia or thrombocytopenia. "
05/01/2001 - "These findings indicate that cepharanthin has the potent therapeutic activity not only on the platelet destruction process, but also on the platelet production process of thrombocytopenia in chronic ITP."