cepharanthine

isoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system afte administration of antineoplastic agents or x-irradiation; structure

Also Known As:

Networked: 143 relevant articles (20 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Okada, Seiji: 4 articles (05/2014 - 09/2009)
2.	Harada, Koji: 4 articles (08/2012 - 03/2003)
3.	Ono, M: 4 articles (09/2001 - 02/2001)
4.	Kao, Ming-Chang: 3 articles (12/2015 - 01/2015)
5.	Sheu, Joen-Rong: 3 articles (12/2015 - 01/2015)
6.	Huang, Chun-Jen: 3 articles (12/2015 - 01/2015)
7.	Ueyama, Yoshiya: 3 articles (08/2012 - 04/2009)
8.	Wu, Jianghong: 3 articles (02/2007 - 06/2002)
9.	Furukawa, Tatsuhiko: 3 articles (06/2005 - 04/2002)
10.	Sumizawa, Tomoyuki: 3 articles (06/2005 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2009 - "These findings demonstrate that the combination of cepharanthine and S-1 is effective against OSCC and has the potential of being a new therapeutic tool for future treatment of these tumors." 10/01/2015 - "Previous studies have demonstrated the antitumor properties of cepharanthine hydrochloride (CH) in several human cancer cells. " 01/01/2014 - "The purpose of the study was to determine the signal transduction mechanism of cepharanthine hydrochloride (CH) on reversing tumor multidrug resistance. " 04/01/1983 - "In this study, for the purpose of protecting leucopenia after administration of anticancer drugs, an effect of cepharanthine which is a kind of alkaroid materials was examined in normal and tumor-bearing mice. " 05/01/2015 - "Cepharanthine is a medicinal plant-derived natural compound which possesses potent anti-cancer properties. "
2.	Thrombocytopenia (Thrombopenia) 10/01/2008 - "Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania Cepharantha Hayata, has been used in Japan for treating patients with radiation-induced leucopenia or thrombocytopenia. " 09/01/1988 - "We conclude that the administration of cepharanthin during CAP therapy promotes the recovery from leucopenia and thrombocytopenia." 09/01/1988 - "As to the platelet count, cepharanthin group also showed attendant toward earlier recovery of thrombocytopenia than non-cepharanthin group. " 07/01/2012 - "When further chemotherapy was avoided because of the patient's poor general condition, administration of cepharanthine was effective in halting progressive thrombocytopenia due to abnormal immune mechanisms. " 07/01/2012 - "Here, we present the successful management of an elderly Japanese patient with multiple myeloma complicated by immune thrombocytopenia with low dose cepharanthine - a plant derived alkaloid. "
3.	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 12/01/2012 - "[Clinical efficacy of high-dose cepharanthine for idiopathic thrombocytopenic purpura: retrospective multicenter analysis]." 03/01/1992 - "Clinical efficacy of oral high-dose cepharanthin (40-60 mg/day) was evaluated in nine patients with idiopathic thrombocytopenic purpura who were unable to discontinue the administration of adrenocorticosteroids or immunosuppressive drugs. " 01/01/1999 - "These findings suggest that genetic studies of HLA and HPA can predict the response of idiopathic thrombocytopenic purpura to cepharanthin." 05/01/2001 - "Pharmacological characterization of cepharanthin in chronic idiopathic thrombocytopenic purpura." 01/01/1999 - "Genetic analysis of HLA- and HPA-typing in idiopathic (autoimmune) thrombocytopenic purpura patients treated with cepharanthin."
4.	Leukopenia 01/01/2001 - "Cepharanthine (CEP) is a known membrane stabilizer that has been widely used in Japan for the treatment of several disorders such as anticancer therapy-provoked leukopenia. " 04/01/1990 - "Cepharanthin, a kind of alkaloid, has been reported to show a protective effect for leukopenia induced by radiation therapy. " 08/01/1989 - "These data suggest that the large dose of Cepharanthine contribute to the prevention of leukopenia in patients who are treated with a sufficient amount of anticancer drugs." 04/01/1990 - "[Effect of cepharanthin on radiotherapy induced leukopenia]." 08/01/1989 - "The effects of Cepharanthine on chemotherapy-induced leukopenia was investigated in our university hospital. "
5.	Lung Injury 12/01/2015 - "Cepharanthine significantly attenuated the pulmonary pro-inflammatory cytokine production and lung injury induced by HS/RES. However, the protective effects of cepharanthine were blocked by SnPP, the potent HO-1 activity inhibitor. " 12/01/2015 - "Cepharanthine mitigates lung injury induced by bilateral lower limb I/R in rats. " 12/01/2015 - "We elucidated whether cepharanthine, a potent antioxidative and anti-inflammatory drug, can mitigate lung injury induced by lower limb I/R. " 02/01/2014 - "The aim of this study was to investigate the protective effects of cepharanthine (CEP) on inflammation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells in vitro and a LPS-induced lung injury model in vivo. " 12/01/2015 - "Cepharanthine significantly reduced the oxidation, inflammation, nuclear factor κB activation, and lung injury induced by I/R. "

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4.	Interleukin-1 (Interleukin 1)
5.	bisbenzylisoquinoline
6.	Quinacrine (Mepacrine)
7.	Ketotifen (Ketotifene)
8.	Glycoproteins (Glycoprotein)
9.	Chlorpromazine (Thorazine)
10.	Adenine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Oral Administration
5.	Adjuvant Chemotherapy