carvone

an oxidized derivative of limonene; RN given refers to cpd without isomeric designation; L-carvone has spearmint flavor, D-carvone has dill/caraway flavor

Also Known As:

(RS)-5-isopropenyl-2-methylcyclohex-2-en-1-one; 2-methyl-5-(1-methylethenyl)-2-cyclohexene-1-one; 2-methyl-5-isopropenyl-2-cyclohexenone; 5-isopropyl-2-methyl-2-cyclohexen-1-one; carvone, (+--)-; carvone, (R)-isomer; carvone, (S)-isomer; limonen-6-one; p-mentha-6,8-dien-2-one

Networked: 74 relevant articles (8 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Monoterpenes: 522
      - Cyclohexane Monoterpenes
        carvone: 74
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexane Monoterpenes
        carvone: 74

Experts

1.	Ahlgren, Camilla: 3 articles (11/2018 - 01/2014)
2.	Bruze, Magnus: 3 articles (11/2018 - 01/2014)
3.	Isaksson, Marléne: 3 articles (11/2018 - 01/2014)
4.	de Sousa, Damião Pergentino: 3 articles (09/2014 - 05/2008)
5.	Fowler, Joseph F: 2 articles (01/2022 - 03/2010)
6.	Shaver, Rob L: 2 articles (01/2022 - 11/2021)
7.	Leitão, Alcino Jorge: 2 articles (07/2021 - 01/2020)
8.	Mendes, Alexandrina Ferreira: 2 articles (07/2021 - 01/2020)
9.	Neves, Bruno Miguel: 2 articles (07/2021 - 01/2020)
10.	Sousa, Cátia: 2 articles (07/2021 - 01/2020)

Related Diseases

1.	Carcinogenesis 02/01/1990 - "NTP Toxicology and Carcinogenesis Studies of d-Carvone (CAS No. 2244-16-8) in B6C3F1 Mice (Gavage Studies)." 03/01/2019 - "We observed 100% tumor incidence in DMBA-painted animals and our results showed that D-carvone at 20 mg dose significantly prevents skin carcinogenesis. " 03/01/2019 - "In the present study, the chemopreventive efficacy of D-carvone was studied in 7, 12-dimethylbenz[a]anthracene (DMBA) induced skin carcinogenesis. " 02/01/1990 - "Based on survival at the high doses in the 13-week studies, 2-year NTP Toxicology and Carcinogenesis studies were conducted by administering d-carvone in corn oil by gavage to groups of 50 male and 50 female mice at doses of 375 or 750 mg/kg, 5 days per week for 103 weeks. " 02/01/1990 - "Toxicity and carcinogenesis studies were conducted by administering d-carvone (approximately 96% pure) in corn oil by gavage to groups of male and female B6C3F1 mice for 16 days, 13 weeks, or 2 years. "
2.	Body Weight (Weight, Body) 03/01/2019 - "Different concentrations of D-carvone (10, 20, 30 mg/kg body weight) were used to assess its anticancer effect. " 11/01/2020 - "Oral treatment of D-carvone significantly improved the body weight, reduced the paw swelling, edema formation, and organ index in arthritic rats. " 12/01/2013 - "In addition, groups IV-VI received different doses of d-carvone (5, 10 and 20 mg/kg body weight everyday orally) along with DMH injections. " 12/01/2013 - "Group II animals received d-carvone every day orally (20 mg/kg body weight) for 16 weeks; groups III-VI received subcutaneous injections of DMH (20 mg/kg body weight) once a week, for the first 4 weeks. " 12/01/2013 - "Overall, results obtained from this study suggest that d-carvone at 10 mg/kg body weight provided optimum protection and could be used as an effective chemopreventive agent against colon carcinogenesis induced by DMH."
3.	Inflammation (Inflammations) 06/01/2023 - "Carvone suppresses oxidative stress and inflammation in the liver of immobilised rats." 01/01/2020 - "(S)-(+)-carvone may be efficient in halting inflammation-related diseases, like osteoarthritis." 11/01/2020 - "D-carvone significantly modulated inflammatory cytokine levels and improved the ankle joint pathology against CFA-induced arthritic inflammation. " 07/04/2021 - "Taken together, these results show that (S)-(+)-carvone is a new SIRT1 activator with the potential to counteract the chronic low-grade inflammation characteristic of age-related diseases." 12/03/2020 - "Our data indicate that carvone enantiomers differentially modulated IgE-mediated airway inflammation in mice. "
4.	Seizures (Absence Seizure) 05/01/2012 - "Cyano-carvone at doses of 25, 50 or 75 mg/kg promoted a reduction of 16.7, 33 and 66.7%, respectively, against pilocarpine-induced seizures, and it was efficacious in increasing both the latency to first seizures and the survival percentage, resulting in 33.3, 67 and 91.7% of protection against death induced by seizures, respectively (P < 0.05). " 05/01/2012 - "In addition, it was observed that the cyano-carvone pretreatment increased the acetylcholinesterase activity in mice hippocampus after pilocarpine-induced seizures. " 09/01/2014 - "In our study we investigated the effects of cyane-carvone (CC), a synthetic substance prepared from natural a monoterpene, carvone, against pilocarpine- (PILO), pentylenetetrazole- (PTZ) and picrotoxine (PTX)-induced seizures in mice after acute treatment with repeated oral doses (CC 25, 50 and 75 mg/kg) for 14 days. "
5.	Neoplasm Metastasis (Metastasis) 03/01/2019 - "However, further studies are warranted to check chemopreventive efficacy of D-carvone on cell proliferation, angiogenesis, and metastasis before going to human trial." 09/01/2003 - "Effect of naturally occurring monoterpenes carvone, limonene and perillic acid in the inhibition of experimental lung metastasis induced by B16F-10 melanoma cells."

Related Drugs and Biologics

1.	Monoterpenes (Monoterpenoids)
2.	Enzymes
3.	Pilocarpine (Ocusert)
4.	Dimenhydrinate (DMH)
5.	anthracene
6.	Cytokines
7.	Streptozocin (Streptozotocin)
8.	Antiparasitic Agents (Antiparasitics)
9.	Limonene
10.	Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1.	Subcutaneous Injections
2.	Injections
3.	Cesarean Section (Caesarean Section)
4.	Oral Administration