N-carbamylglutamate

03/01/2021 - "N-Carbamylglutamate may be deemed an effective and safe treatment modality in the chronic management of hyperammonemia in patients with PA and MMA."
12/20/2018 - "We established the 9-site N-carbamylglutamate Consortium (NCGC) in order to conduct two randomized double-blind, placebo-controlled trials of NCG in acute hyperammonemia of PA, MMA, CPSD and OTCD. "
12/01/2002 - "A therapeutic trial with carbamylglutamate is recommended whenever hyperammonemia without an organic aciduria, increased orotate excretion, or diagnostic amino acidemia/uria is detected."
03/01/2021 - "Acute hyperammonemia episodes can be treated effectively with N-carbamylglutamate (NCG). "
03/01/2021 - "Long-term N-carbamylglutamate treatment of hyperammonemia in patients with classic organic acidemias."

12/01/2021 - "NAGSD is the only urea cycle disorder that can be effectively treated with a single drug, N-carbamylglutamate (NCG), a stable NAG analog, which activates CPS1 to restore ureagenesis. "
10/18/2018 - "NAGSD is the only urea cycle disorder that can be treated with a single drug, N-carbamylglutamate (NCG), which can activate CPS1 and completely restore ureagenesis in patients with NAGSD. "
09/01/2016 - "Although NAGS deficiency is the rarest urea cycle disorder, it is the only one that can be specifically and effectively treated by a drug, N-carbamylglutamate, a stable structural analogous of NAG that activates CPS1. "
10/17/2023 - "NAGS deficiency (NAGSD) is the rarest of the urea cycle disorders, yet is unique in that ureagenesis can be restored with the drug N-carbamylglutamate (NCG). "
05/01/2013 - "N-carbamylglutamate is approved for the treatment of hyperammonemia in N-acetylglutamate synthetase deficiency and may have efficacy in other urea cycle disorders. "

05/01/2016 - "This study was conducted with an ovine intrauterine growth restriction (IUGR) model to test the hypothesis that dietary -carbamylglutamate (NCG) and rumen-protected -Arg (RP-Arg) supplementation are effective in ameliorating fetal growth restriction in undernourished ewes. "
07/01/2018 - "The present study was conducted with an ovine intrauterine growth restriction (IUGR) model to test the hypothesis that dietary rumen-protected l-arginine (RP-Arg) or N-carbamylglutamate (NCG) supplementation in underfed ewes is effective in enhancing fetal growth. "
12/01/2022 - "Previous studies have revealed that dietary N-carbamylglutamate (NCG) or L-arginine (Arg) improves small intestinal integrity and immune function in suckling Hu lambs that have experienced intrauterine growth retardation (IUGR). "
11/15/2022 - "Our previous studies have revealed that dietary N-carbamylglutamate (NCG) and L-arginine (Arg) supplementation improves redox status and suppresses apoptosis in the colon of suckling Hu lambs with intrauterine growth retardation (IUGR). "
09/01/2021 - "The objective of this study was to investigate the effects of dietary administration of l-arginine (Arg) or N-carbamylglutamate (NCG) on hepatic energy status and mitochondrial functions in suckling Hu lambs with intrauterine growth retardation (IUGR). "

04/22/2018 - "Long-term continuous N-carbamylglutamate treatment in frequently decompensated propionic acidemia: a case report."
01/01/2012 - "Short-term outcome of propionic aciduria treated at presentation with N-carbamylglutamate: a retrospective review of four patients."
01/01/2005 - "N-carbamylglutamate protects patients with decompensated propionic aciduria from hyperammonaemia."
04/22/2018 - "N-carbamylglutamate ameliorates hyperammonemia in decompensated propionic acidemia. "
04/01/2010 - "The aim of this research letter was to describe the use of N-carbamoyl-L-glutamate as first-line treatment of hyperammonemia in a 4-month-old female patient with propionic acidemia (PA). "

01/01/2016 - "N-Carbamylglutamate Is an Effective Treatment for Acute Neonatal Hyperammonaemia in a Patient with Methylmalonic Aciduria."
01/01/2023 - "Management of methylmalonic acidemia (MMA) with N-carbamylglutamate: A case report from Italy."
09/01/2016 - "Clinical experience with N-carbamylglutamate in a single-centre cohort of patients with propionic and methylmalonic aciduria."
09/01/2016 - "The effect of long-term N-carbamylglutamate (NCG) treatment on the rate and severity of decompensations due to propionic aciduria (PA) and methylmalonic aciduria (MMA) is unknown. "
01/01/2010 - "N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria."