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brilliant blue (brilliant blue FCF)

coal tar derivative food dye; used as the di-NH4 or di-Na salts; RN given refers to parent cpd
Also Known As:
brilliant blue FCF; C.I. 42090; CI 42090; D & C blue no.4; DC blue no. 4; F D & C blue #1; FD&C blue No.1; acid blue 9; blue 4; blue no. 1; brilliant blue Al (3:1) salt; brilliant blue FCF, diammonium salt; brilliant blue diammonium salt; brilliant blue dipotassium salt; brilliant blue potassium, sodium salt; brilliant blue, aluminium salt; brilliant blue, disodium salt; caries check blue; erioglaucine; food blue 2
Networked: 59 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sevim, Mehmet Sahin: 3 articles (05/2014 - 01/2011)
2. Rodrigues, Eduardo B: 3 articles (07/2012 - 09/2009)
3. Meyer, Carsten H: 2 articles (09/2021 - 09/2009)
4. Battastini, Ana Maria Oliveira: 2 articles (03/2020 - 01/2016)
5. Gubert, Carolina: 2 articles (03/2020 - 01/2016)
6. Kapczinski, Flávio: 2 articles (03/2020 - 01/2016)
7. Malla, Om Krishna: 2 articles (05/2019 - 01/2019)
8. Pokharel, Ram Prasad: 2 articles (05/2019 - 01/2019)
9. Shakya, Kiran: 2 articles (05/2019 - 01/2019)
10. Arora, Supriya: 2 articles (08/2016 - 01/2016)

Related Diseases

1. Ischemia
10/01/2015 - "Treatment with the agonist of the P2Y2 subtype 2-thio-UTP and with the antagonist of the P2X7 subtype Brilliant Blue improved myocardial function parameters, reduced cell death and increased the myocardial expression of antiapoptotic markers after ischemia-reperfusion. "
11/28/2018 - "ERK inhibition is probably involved in the protective effects of P2X7R inhibitor against cerebral I/R injury, which may be related to the reduction of Cx43 and cleaved caspase-3, and the ratio of Bax/Bcl-2. 目的:探讨拮抗P2X7受体(P2X7 receptor,P2X7R)在保护大鼠脑缺血/再灌注(ischemia/reperfusion,I/R)损伤中的作用及其机制。方法:采用改良线栓法建立大鼠大脑中动脉栓塞(middle cerebral artery occlusion,MCAO)模型;随后对其进行缺血2 h再灌注24 h处理,完成大鼠大脑局灶性脑I/R损伤模型的制备。采用Longa五分法对大鼠进行神经行为学评分;2,3,5-氯化三苯基四氮唑(TTC)染色法检测大鼠大脑梗死体积的变化;Western印迹检测细胞外信号调节激酶(extracellular signal-regulated kinase,ERK),磷酸化细胞外信号调节激酶(phosphorylation extracellular signal-regulated kinase,p-ERK),缝隙连接蛋白43(connexin 43,Cx43),Bax,Bcl-2及cleaved caspase-3蛋白表达的变化。结果:Longa五分法与TTC染色法结果显示:与假手术组比较,I/R组大鼠神经行为学评分(P<0.05)和大脑梗死体积(P<0.01)均明显增加。与I/R组大鼠相比,P2X7R拮抗剂明亮蓝(brilliant blue G,BBG)或ERK抑制剂PD98059均可明显降低大鼠神经行为学评分(P<0.01)和大鼠大脑梗死体积(P<0.05)。在阻断P2X7R的基础上使用PD98059抑制ERK活性后,大鼠神经行为学评分和大脑梗死体积进一步降低(P<0.05);Western印迹结果显示:BBG或PD98059均可降低p-ERK,Cx43,Bax/Bcl-2及cleaved caspase-3蛋白表达量(P<0.05)。在阻断P2X7R的基础上使用PD98059抑制ERK活性后,p-ERK,Cx43,Bax/Bcl-2及cleaved caspase-3等蛋白表达量进一步降低(P<0.05)。结论:拮抗P2X7R可减轻大鼠脑I/R损伤,其机制可能与抑制ERK激活,进而降低Cx43和cleaved caspase-3蛋白表达及Bax/Bcl-2比值有关。."
2. Retinal Perforations
3. Cataract (Cataracts)
4. Hemorrhage
5. Necrosis

Related Drugs and Biologics

1. Caspase 3 (Caspase-3)
2. Caspases
3. Connexin 43 (Connexin43)
4. Coloring Agents (Dyes)
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. Tartrazine
7. Styrene (Styrol)
8. Sodium Selenite
9. Selenium Compounds
10. Solvents

Related Therapies and Procedures

1. Capsulorhexis
2. Vitrectomy
3. Microspheres (Microsphere)
4. Traction
5. Intraocular Lenses (Intraocular Lens)