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benzotriphenylene
Also Known As:
1,2,3,4-dibenzanthracene; benzo(b)triphenylene; dibenz(a,c)anthracene; dibenzo(a,c)anthracene
Networked:
9
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Benz(a)Anthracenes: 2
benzotriphenylene: 9
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Benz(a)Anthracenes: 2
benzotriphenylene: 9
Related Diseases
1.
Neoplasms (Cancer)
05/01/1983 - "
The tumor-initiating activities of dibenz[a,c]anthracene (DBA) and of the related trans-1,2-, 3,4- and 10,11-dihydrodiols have been examined on mouse skin subsequently promoted with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).
"
02/01/1998 - "
Dermal and epidermal EROD specific activities in microsomal samples prepared from both tumor-bearing and non-tumor-bearing mice were elevated 9- to 14- and 43- to 77-fold, respectively, above constitutive levels 16-20 h after a single topical application of 100 nmol of dibenz[a,c]anthracene (DB[a,c]A).
"
12/15/1983 - "
Dibenz[a,c]anthracene proved to be a relatively weak carcinogen, producing less than 3% tumor incidence at doses up to 300 micrograms per mouse.
"
01/01/1980 - "
The bromo-compound is also a powerful promoter of tumors initiated in mouse skin with 7,12-dimethylbenz(a)anthracene, whereas dibenz-(a,c)anthracene is inactive as a promoter.
"
03/01/1978 - "
Dibenz[a,c]anthracene: a potent inhibitor of skin-tumor initiation by 7,12-dimethylbenz[a]anthracene.
"
2.
Hepatocellular Carcinoma (Hepatoma)
03/01/1993 - "
Treatment of murine hepatoma 1c1c7 cultures with dibenz[a,c]anthracene (DB[a,c]A)-induced P450 Cyp1a-1, as indicated by analyses of CYP1A1 mRNA and 7-ethoxyresorufin O-deethylase (EROD) activity.
"
3.
Fibrosarcoma
12/15/1983 - "
The relationship between the Ah locus and the induction of subcutaneous fibrosarcomas by dibenz[a,h]anthracene and dibenz[a,c]anthracene was investigated in C57BL/6J (Ahb/Ahb), (C57BL/6J)(DBA/2J)F1 (Ahb/Ahd) and (Ahd/Ahd) mice.
"
Related Drugs and Biologics
1.
Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)
2.
benzo(e)pyrene
3.
Carcinogens
4.
Cytochrome P-450 CYP1A1 (CYP1A1)
5.
9,10-Dimethyl-1,2-benzanthracene
6.
anthracene
7.
1,2,5,6-dibenzanthracene (dibenz(a,h)anthracene)
8.
Messenger RNA (mRNA)
9.
Methylcholanthrene
10.
Cyclic Hydrocarbons