methylatropine

RN given refers to endo-(+-)-isomer; structure in Negwer, 5th ed, #3766

Also Known As:

8-methylatropinium nitrate; N-methylatropine; atropine iodomethylate; atropine methonitrate; atropine methylbromide; methyl atropine; methylatropine bromide; methylatropine iodide; methylatropine iodide, (endo-(+-))-isomer; methylatropine iodide, (endo-3(R))-isomer; methylatropine iodide, (endo-3(S))-isomer; methylatropine iodide, 3H-labeled, (endo-(+-))-isomer; methylatropine nitrate; methylatropine nitrate, (endo-(+-))-isomer; methylatropine nitrite, (endo-(+-))-isomer; methylatropine sulfate (2:1), (endo-(+-))-isomer; methylatropine, endo-3(R)-isomer; methylatropine, endo-3(S)-isomer

Networked: 125 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lahlou, Saad: 10 articles (04/2019 - 12/2002)
2.	Magalhães, Pedro Jorge Caldas: 9 articles (04/2019 - 12/2002)
3.	Duarte, Gloria Pinto: 5 articles (04/2015 - 02/2004)
4.	Leal-Cardoso, José Henrique: 4 articles (04/2006 - 12/2002)
5.	de Siqueira, Rodrigo José Bezerra: 3 articles (08/2013 - 10/2005)
6.	Duarte, Glória Pinto: 2 articles (04/2019 - 01/2007)
7.	Fazan, Rubens: 2 articles (04/2016 - 09/2011)
8.	David, Jorge Maurício: 2 articles (04/2015 - 01/2007)
9.	David, Juceni Pereira: 2 articles (04/2015 - 01/2007)
10.	Figueiredo, André Fernandes: 2 articles (10/2005 - 12/2002)

Related Diseases

1.	Bradycardia 04/01/2016 - "Nevertheless, the reflex bradycardia was attenuated by methylatropine in control, but not in CHF rats. " 05/01/2000 - "Furthermore, pretreatment with methylatropine to block the PSNS had no effect on bradycardia, whereas blocking SNS influences on cardiac function significantly attenuated the fall in heart rate during peripheral hyperosmolality. " 01/01/1999 - "The data show that 1) ES of the ADN produces a fall in pressure, bradycardia, vasodilation in the hindquarter, and no changes in the mesenteric vascular resistance, 2) methylatropine blocked the bradycardia and produced no effect on the hypotensive response to ES of the ADN, and 3) the baroreceptor afferent fibers involved in the hypotensive response to ES of ADN are sensitive to the variation of the frequency of the stimuli, whereas the fibers involved in the bradycardic response are not." 04/01/1996 - "This attenuation was conserved following blockade of bradycardia with methylatropine (P < 0.01). " 12/01/1993 - "In left vagotomized rats, the DpV remained unchanged after methyl atropine (i.v), but the bradycardia response during the DpV was attenuated. "
2.	Asthma (Bronchial Asthma) 01/01/1968 - "Atropine methonitrate in bronchial asthma." 04/18/1964 - "SOME ADRENERGIC DRUGS AND ATROPINE METHONITRATE GIVEN BY INHALATION FOR ASTHMA: A COMPARATIVE STUDY." 11/17/1962 - "Atropine methonitrate and isoprenaline in bronchial asthma." 03/01/2011 - "Previous studies with the short-acting inhaled anticholinergics, ipratropium bromide, oxitropium bromide, and atropine methonitrate, have failed to demonstrate improved outcomes in chronic persistent asthma. " 02/01/1982 - "In ten adult patients with severe, partially reversible airflow obstruction due to asthma, with or without co-existent chronic bronchitis, the acute bronchodilator responses of ipratropium bromide (40 micrograms) and terbutaline (500 micrograms) from metered-dose inhalers, atropine methonitrate (2 mg) as a wet aerosol and placebo were compared in a double blind trial. "
3.	Hypotension (Low Blood Pressure) 09/01/1981 - "After intravenous administration, only doses higher than 28 micrograms per kg evoked hypotension, which could not be blocked by intravenously administered N-methylatropine. " 02/01/1994 - "Aortic nerve stimulation caused frequency-dependent hypotension, which was unaffected by methyl-atropine, and bradycardia, which was eliminated by methyl-atropine. " 04/15/2019 - "In conscious rats, the dose-dependent hypotension and bradycardia evoked by T4MeN were abolished by i.v. methylatropine pretreatment. " 08/01/2013 - "Hypotension and bradycardia of EOCZ (phase 1) were abolished and respectively reversed into pressor and tachycardiac effects by methylatropine (1 mg/kg, i.v.) pretreatment. " 01/01/1999 - "In the first group of rats (n = 7), the control ES of the ADN in the range from 0.5 to 3.0 V (50 Hz, 10 ms) produced bradycardia and hypotension in an intensity-dependent manner, and treatment with methylatropine (intravenously) blocked the bradycardia but produced no significant changes in the hypotensive response. "
4.	Anticholinergic Syndrome 12/01/1983 - "We concluded that methyl atropine bromide is superior to atropine sulphate because it does not produce side effects which may cause the central anticholinergic syndrome. "
5.	Hyperglycemia 01/01/2012 - "Interestingly, pre-treatment of rats with acetylcholine (ACh) receptor antagonists-atropine sulfate and methyl atropine nitrate offered significant protection against hyperglycemia, hypercorticosteronemia and increased liver TAT activity induced by monocrotophos. "

Related Drugs and Biologics

1.	Atropine
2.	Propranolol (Inderal)
3.	Phenylephrine (Neo-Synephrine)
4.	Ipratropium (Ipratropium Bromide)
5.	Cholinergic Antagonists (Anticholinergics)
6.	oxitropium (oxitropium bromide)
7.	Cholinergic Receptors
8.	Nitrates
9.	Monocrotophos (Azodrin)
10.	Bromides

Related Therapies and Procedures

1.	Vagotomy
2.	Metered Dose Inhalers (Metered Dose Inhaler)
3.	Truncal Vagotomy
4.	Intravenous Injections
5.	Controlled Hypotension