phenobarbital drug combination febarbamate difebarbamate

combination of 15mg phenobarbital, 50mg febarbamate & 50mg difebarbamate; used to treat withdrawal in alcoholism; structure

Also Known As:

difebarbamate, febarbamate, phenobarbital drug combination; Atrium (drug); Atrium 300; difebarbamate - febarbamate - phenobarbital; tetrabamate; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-bis(2-((aminocarbonyl)oxy)-3-butoxypropyl)-5-ethyl-5-phenyl-, mixt. with 1-(2-((aminocarbonyl)oxy)-3-butoxypropyl)-5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione and 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione

Networked: 9 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bellemin, B: 1 article (09/2000)
2.	Berger, F: 1 article (09/2000)
3.	Chevallier, M: 1 article (09/2000)
4.	Dumortier, J: 1 article (09/2000)
5.	Jacob, P: 1 article (09/2000)
6.	Scoazec, J Y: 1 article (09/2000)
7.	Vial, T: 1 article (09/2000)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 09/01/1986 - "The anxiolytic efficacy of tetrabamate was evaluated in 68 out-patients presenting an anxiety state with alcohol abuse according to DSM III criteria. " 09/01/1995 - "Studies of zimeldine, nialamide, L-dopa, viloxazine, and tetrabamate failed to demonstrate efficacy for these agents in the treatment of alcoholism. "
2.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 05/13/1995 - "In view of this potentially lethal adverse effect of tetrabamate, it should not be used for ethanol withdrawal symptoms." 05/13/1995 - "We report on a 28-year-old female patient admitted to hospital with acute liver failure after treatment with tetrabamate because of alcohol withdrawal symptoms. " 07/01/1991 - "The data on these measures confirmed the anxiolytic efficacy of tetrabamate and showed some advantages in the tetrabamate group in comparison with the lorazepam group: a better global tolerance at the study end point (day 35), a greater efficacy on some anxiety somatic items and lesser frequency and severity of withdrawal symptoms during treatment tapering off." 09/01/2000 - "Tetrabamate (Atriums), widely used in the treatment of tremor and ethanol-withdrawal symptoms, has been incriminated as a potential cause of reversible acute hepatitis. " 05/13/1995 - "Tetrabamate (Atrium), a composite preparation of phenobarbital, difebarbamate and febarbamate, is widely used to reduce ethanol withdrawal symptoms such as tremor, agitation and anxiety. "
3.	Tremor (Tremors) 01/01/1989 - "5. Tetrabamate was found particularly beneficial for severe tremor. " 09/01/2000 - "Tetrabamate (Atriums), widely used in the treatment of tremor and ethanol-withdrawal symptoms, has been incriminated as a potential cause of reversible acute hepatitis. " 05/13/1995 - "Tetrabamate (Atrium), a composite preparation of phenobarbital, difebarbamate and febarbamate, is widely used to reduce ethanol withdrawal symptoms such as tremor, agitation and anxiety. "
4.	Anxiety Disorders (Anxiety Disorder) 07/01/1991 - "The anxiolytic efficacy of tetrabamate was evaluated in a multicentric double-blind study versus lorazepam and placebo, in 269 patients with a generalized anxiety disorder according to DSM III-R criteria. "
5.	Medically Unexplained Symptoms 09/01/1986 - "Moreover, in the tetrabamate group the significantly greater improvement in the scores of somatic symptoms indicates that the compound caused no notable adverse effects and its activity on somatic complaints (psychopathologic and/or toxic)."

Related Drugs and Biologics

1.	Anti-Anxiety Agents (Anxiolytics)
2.	Zimeldine (Zimelidine)
3.	Viloxazine
4.	Nialamide
5.	Lorazepam (Ativan)
6.	Levodopa (L Dopa)
7.	Ethanol (Ethyl Alcohol)
8.	Phenobarbital (Luminal)
9.	difebarbamate
10.	febarbamate

Related Therapies and Procedures

1.	Aftercare (After-Treatment)

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