aplysiatoxin

10/01/2023 - "Invivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest."
01/01/2015 - "Aplog-1 is a simplified analog of the tumor-promoting aplysiatoxin with anti-proliferative and cytotoxic activities against several cancer cell lines. "
04/01/2014 - "We have recently identified 10-methyl-aplog-1 (26), a simplified analog of tumor-promoting aplysiatoxin (ATX), as a possible therapeutic lead for cancer. "
05/01/2012 - "The authors focused on the bryo-1's unique mechanism of activating PKCδ that plays a tumor suppressor role, and found that a simple and less lipophilic analogue (aplog-1) of the tumor-promoting aplysiatoxin showed PKCδ-activating behavior similar to bryo-1. "
01/01/2011 - "Synthesis and biological evaluation of the 12,12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin."

01/01/1995 - "Aplysiatoxin and debromoaplysiatoxin, a debrominated form of aplysiatoxin, have both been shown to be potent tumor promoters in a two-stage carcinogenesis experiment on mouse skin. "
04/01/1985 - "Aplysiatoxin and debromoaplysiatoxin were recently found to be potent tumor promoters in two-stage carcinogenesis in mouse skin. "
01/01/1983 - "Teleocidin and aplysiatoxin, which are structurally different from 12-O-tetradecanoylphorbol-13-acetate (TPA), were found to be potent tumor promoters in two-step mouse skin carcinogenesis. "
03/01/1986 - "Based on their binding to the phorbol ester receptors of cell membranes, these new tumor promoters were classified as TPA-type tumor promoters, teleocidin and aplysiatoxin, which like TPA, activated protein kinase C in vitro, whereas two non-TPA-type tumor promoters, palytoxin and thapsigargin did not induce ODC activity in mouse skin, adhesion of HL-60 cells or activation of protein kinase C, but did show tumor-promoting activity in a two-stage carcinogenesis experiment. "

05/01/2002 - "The cause of death and the effective dose levels resembled those of aplysiatoxin poisoning."
01/01/2000 - "The cause of death by aplysiatoxin poisoning was bleeding from the small intestine in mice. "
01/01/2000 - "Bleeding from the small intestine caused by aplysiatoxin, the causative agent of the red alga Gracilaria coronopifolia poisoning."
12/01/1998 - "Morphological observations of diarrhea in mice caused by aplysiatoxin, the causative agent of the red alga Gracilaria coronopifolia poisoning in Hawaii."
07/01/1996 - "The human symptoms and the amount of these toxins in the original algal samples indicate that aplysiatoxin and debromoaplysiatoxin were the causative agents of the human poisoning incidents. "

01/01/2000 - "The cause of death by aplysiatoxin poisoning was bleeding from the small intestine in mice. "
01/01/2000 - "Bleeding from the small intestine caused by aplysiatoxin, the causative agent of the red alga Gracilaria coronopifolia poisoning."

07/01/1996 - "This is the first reported case of the implication of aplysiatoxin and debromoaplysiatoxin in food poisoning. "