2-anthramine

04/01/1982 - "Interaction of beta radiation and 2-anthramine for induction of skin tumors in rats."
12/01/1955 - "The production of a variety of skin tumors in rats with 2-anthramine, and a comparison with the effects in mice."
01/01/1995 - "Aflatoxin B1, 2-aminoanthracene, and 7,12-dimethylbenz[a]anthracene have been implicated in the etiology of human cancers. "
02/01/1985 - "Since the skin of the rat is known to be susceptible to tumor induction by 2-aminoanthracene our findings re-emphasize that membrane-bound enzymes can influence toxic responses including mutagenicity to xenobiotics in cutaneous tissue."
11/01/1984 - "Neoplasms were induced by a single injection of 13 and 25 ng per egg of aflatoxin B1 (CAS: 1162-65-8), 500 ng per egg of 7,12-dimethylbenz[a]anthracene (CAS: 57-97-6), and 250 ng per egg of 2-anthramine (CAS: 613-13-8). "

04/01/1970 - "Dermal collagen changes during 2-aminoanthracene carcinogenesis in the rat."
12/01/1963 - "THE EFFECT OF CYCLOPHOSPHAMIDE ON 2-AMINOANTHRACENE CARCINOGENESIS IN RAT SKIN."
03/01/2007 - "Each extract was also assayed for antioxidant activity and for its ability to inhibit activity of matrix metalloproteinases-2 and -9. Each of the four extracts showed significant inhibition of 2-aminoanthracene mutagenesis, high antioxidant activity, and the ability to inhibit activities of both metalloproteinases, implying that these extracts could be good inhibitors of carcinogenesis. "

10/29/2010 - "Cytosine arabinoside, vinblastine, 5-fluorouracil and 2-aminoanthracene testing in the in vitro micronucleus assay with L5178Y mouse lymphoma cells at Sanofi Aventis, with different cytotoxicity measurements, in support of the draft OECD Test Guideline on In Vitro Mammalian Cell Micronucleus Test."
10/29/2010 - "The reference genotoxic agents mitomycin C, cadmium chloride, 2-aminoanthracene, vinblastine sulphate and 5-fluorouracil were tested in the in vitro micronucleus assay, in mouse lymphoma L5178Y cells and in human lymphoblastoid cells TK6, without cytokinesis block. "
10/29/2010 - "Etoposide, cadmium chloride, benzo[a]pyrene, cyclophosphamide and colchicine tested in the in vitro mammalian cell micronucleus test (MNvit) in the presence and absence of cytokinesis block using L5178Y mouse lymphoma cells and 2-aminoanthracene tested in MNvit in the absence of cytokinesis block using TK6 cells at AstraZeneca UK, in support of OECD draft Test Guideline 487."
10/29/2010 - "Cytosine arabinoside (a nucleoside analogue that inhibits the gap-filling step of excision repair), vinblastine (an aneugen that inhibits tubulin polymerisation), 5-fluorouracil (a nucleoside analogue with a steep response profile), and 2-aminoanthracene (a metabolism-dependent reference genotoxin) were tested in the in vitro micronucleus assay with L5178Y mouse lymphoma cells, without cytokinesis block. "

09/01/2010 - "Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells."
09/01/2010 - "We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene therapy. "

01/01/2012 - "Hepatic gene expression analysis of 2-aminoanthracene exposed Fisher-344 rats reveal patterns indicative of liver carcinoma and type 2 diabetes."