allotetrahydrocortisol

RN given refers to (3alpha,5alpha,11beta)-isomer

Also Known As:

5alphaTHF; allotetrahydrocortisol, (3alpha,5beta,11alpha)-isomer; allotetrahydrocortisol, (3beta,5alpha,11beta)-isomer; allotetrahydrocortisol, (3beta,5beta,11beta)-isomer; allotetrahydrocortisol, (5alpha,11beta)-isomer; 3-alpha,11-beta,17,21-tetrahydroxy-5-alpha-pregnan-20-one

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Ping: 1 article (07/2014)
2.	Dai, Weidong: 1 article (07/2014)
3.	Kong, Hongwei: 1 article (07/2014)
4.	Lu, Xin: 1 article (07/2014)
5.	Luo, Ping: 1 article (07/2014)
6.	Xu, Guowang: 1 article (07/2014)
7.	Xu, Zhiliang: 1 article (07/2014)
8.	Yin, Peiyuan: 1 article (07/2014)
9.	Carletto, Antonio: 1 article (03/2008)
10.	Corrocher, Roberto: 1 article (03/2008)

Related Diseases

1.	Hypertension (High Blood Pressure) 08/01/1991 - "To study the possible impairment of 11 beta-hydroxysteroid-dehydrogenase in patients with chronic renal insufficiency, urinary excretion rates of the four main glucocorticoid-metabolites, tetrahydrocortisol, tetrahydrocortisone, allotetrahydrocortisol and allotetrahydrocortisone were determined by capillary gas chromatography in 22 patients with chronic renal insufficiency with (N = 15) and without (N = 7) hypertension, but without hemodialysis treatment. " 03/01/2008 - "The aim of the present work was to define the possible role of abnormal cortisol/cortisone handling, as revealed by an urinary tetrahydrocortisol + allotetrahydrocortisol (THFs)/tetrahydrocortisone (THE) ratio between 1.5 and 3.0, by measuring urinary cortisol and cortisone metabolites in: normotensive individuals (n = 100) who received 7-8 mg/day of oral prednisone and were then followed for development of hypertension; essential hypertensive (EH) participants from primary care (n = 103); and EH hypertensive patients referred to the Hypertension Unit (n = 141). "
2.	Chronic Renal Insufficiency 08/01/1991 - "To study the possible impairment of 11 beta-hydroxysteroid-dehydrogenase in patients with chronic renal insufficiency, urinary excretion rates of the four main glucocorticoid-metabolites, tetrahydrocortisol, tetrahydrocortisone, allotetrahydrocortisol and allotetrahydrocortisone were determined by capillary gas chromatography in 22 patients with chronic renal insufficiency with (N = 15) and without (N = 7) hypertension, but without hemodialysis treatment. "
3.	Virilism (Virilization) 04/01/1988 - "To discriminate between LO-CAH and virilization of unknown origin and precocious pubarche, we calculated the following ratios: (1) pregnanetriol to tetrahydrocortisone (PT/THE), (2) the sum of 17-OH-PO, PT and 11-O-PT (OHP-M) to the sum of THE, tetrahydrocortisol (THF) and allotetrahydrocortisol (a-THF) (C-M) and (3) 11-O-PT to C-M. "
4.	Fibrosis (Cirrhosis) 07/01/2014 - "Logistic regression analysis reveals that a panel of two urinary steroid hormones (epitestosterone and allotetrahydrocortisol) displayed excellent diagnostic capability for distinguishing early HCC from cirrhosis with area under the curve (AUC) = 0.938 of receiver operating characteristic (ROC) analysis. "
5.	Acromegaly 01/01/2005 - "Hence, the preponderance of the main cortisone-derived metabolite, tetrahydrocortisone, over the main metabolites of cortisol (tetrahydrocortisol and allotetrahydrocortisol; p < 0.01), which was seen both in female and in male acromegalics and which was directly correlated with the postglucose concentrations of growth hormone (r = 0.508, p < 0.01), suggests a decreased activity of 11beta-hydroxysteroid dehydrogenase type 1 in acromegaly. "

Related Drugs and Biologics

1.	Tetrahydrocortisone
2.	Tetrahydrocortisol
3.	11-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)
4.	Glucocorticoids
5.	Hydrocortisone (Cortisol)
6.	Cortisone
7.	11-beta-Hydroxysteroid Dehydrogenase Type 1
8.	Steroids
9.	Growth Hormone (Somatotropin)
10.	Pregnanetriol

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)