aflatoxin B1-2,3-oxide

Also Known As:

AFB epoxide; AFB1-2,3-oxide; aflatoxin B1-8,9-epoxide; Cyclopent(c)oxireno(4',5')furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,10-dione, 2,3,6a,7a,8a,8b-hexahydro-4-methoxy-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Aflatoxins: 1770
        Aflatoxin B1: 1058
        aflatoxin B1-2,3-oxide: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Aflatoxins: 1770
        Aflatoxin B1: 1058
        aflatoxin B1-2,3-oxide: 3
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Aflatoxins: 1770
      - Aflatoxin B1: 1058
        aflatoxin B1-2,3-oxide: 3

Related Diseases

1.	Chronic Hepatitis (Chronic Active Hepatitis) 11/14/1997 - "Metabolic activation of aflatoxin B1 to aflatoxin B1-8,9-epoxide in woodchucks undergoing chronic active hepatitis." 11/14/1997 - "In the present study, we have tested the hypothesis that the metabolic activation of aflatoxin B1 to aflatoxin B1-8,9-epoxide, the ultimate mutagenic and carcinogenic mycotoxin metabolite, is enhanced in an experimental model of chronic hepatitis using woodchucks, chronically infected with the woodchuck hepatitis virus. "
2.	Carcinogenesis 12/01/1986 - "These results support the hypothesis that BHA inhibits AFB carcinogenesis via the induction of phase II biotransformation pathways such as glutathione S-transferase, which act to reduce the amount of AFB-epoxide available for binding to DNA. "
3.	Hepatocellular Carcinoma (Hepatoma) 08/15/1996 - "This protein is now referred to as rGSTA5 and is noteworthy because of its high activity towards aflatoxin B1-8,9-epoxide, its marked inducibility by chemoprotectors, its sex-specific regulation, and its over-expression in hepatoma and preneoplastic nodules. "
4.	Hepatitis 11/14/1997 - "In woodchuck hepatitis virus-positive woodchucks, activation of aflatoxin B1 to aflatoxin B1-8,9-epoxide was reduced when compared to woodchuck hepatitis virus-free animals, and the extent of the reduction was dependent on the severity of the hepatitis. "

Related Drugs and Biologics

1.	Aflatoxin B1 (Aflatoxin B)
2.	Mycotoxins
3.	Proteins (Proteins, Gene)
4.	Glutathione Transferase (Glutathione S-Transferase)
5.	DNA (Deoxyribonucleic Acid)
6.	Butylated Hydroxyanisole (BHA)