acetosulfame (acesulfame K)

RN given refers to parent cpd

Also Known As:

acesulfame K; acesulfam-K; acesulfame calcium; acesulfame potassium; acesulfame sodium; acetosulfam; acetosulfam potassium; acetosulfam, potassium salt; acetosulfam, sodium salt; acetosulfame calcium; 3,4-dihydro-6-methyl-1,2,3-oxathiazin-4-one-2,2-dioxide potassium salt

Networked: 41 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hans, Joachim: 2 articles (07/2018 - 05/2018)
2.	Somoza, Veronika: 2 articles (07/2018 - 05/2018)
3.	Zopun, Muhammet: 2 articles (07/2018 - 05/2018)
4.	Fagt, S: 2 articles (06/2008 - 03/2007)
5.	Leth, T: 2 articles (06/2008 - 03/2007)
6.	Cameron, Hunter James: 1 article (07/2022)
7.	Driemert, Peter: 1 article (07/2022)
8.	Giri, Varun: 1 article (07/2022)
9.	Haake, Volker: 1 article (07/2022)
10.	Kamp, Hennicke: 1 article (07/2022)

Related Diseases

1.	Weight Gain 10/01/2016 - "There now exists a body of evidence, from a number of investigators, that animals chronically exposed to any of a range of LCSs - including saccharin, sucralose, acesulfame potassium, aspartame, or the combination of erythritol+aspartame - have exhibited one or more of the following conditions: increased food consumption, lower post-prandial thermogenesis, increased weight gain, greater percent body fat, decreased GLP-1 release during glucose tolerance testing, and significantly greater fasting glucose, glucose area under the curve during glucose tolerance testing, and hyperinsulinemia, compared with animals exposed to plain water or - in many cases - even to calorically-sweetened foods or liquids. "
2.	Hyperinsulinism (Hyperinsulinemia) 10/01/2016 - "There now exists a body of evidence, from a number of investigators, that animals chronically exposed to any of a range of LCSs - including saccharin, sucralose, acesulfame potassium, aspartame, or the combination of erythritol+aspartame - have exhibited one or more of the following conditions: increased food consumption, lower post-prandial thermogenesis, increased weight gain, greater percent body fat, decreased GLP-1 release during glucose tolerance testing, and significantly greater fasting glucose, glucose area under the curve during glucose tolerance testing, and hyperinsulinemia, compared with animals exposed to plain water or - in many cases - even to calorically-sweetened foods or liquids. "
3.	Body Weight (Weight, Body) 10/01/2005 - "9-MONTH STUDY IN Tg.AC HEMIZYGOUS MICE: Groups of 15 male and 15 female Tg.AC hemizygous mice were fed diets containing 0%, 0.3%, 1%, or 3% acesulfame potassium (equivalent to average daily doses of approximately 420, 1,400, or 4,500 mg acesulfame potassium/kg body weight to males and 520, 1,700, or 5,400 mg/kg to females) for 40 weeks. " 10/01/2005 - "Exposure to acesulfame potassium had no effect on survival or mean body weights. " 10/01/2005 - "Exposure to acesulfame potassium had no effect on survival or mean body weights. " 12/01/1997 - "Doses of 15, 30, 60, 450, 1500 and 2250 mg of acesulfame-K/kg body weight induced a positive dose-dependent significant clastogenicity (trend test alpha < 0.05). " 01/01/2014 - "Among female students, the normal weight group showed a higher consumption of acesulfame K per kilogram of body weight than the overweight group (p < 0.05). "
4.	Insulin Resistance 01/01/2018 - "These findings suggest that the daily consumption of 2 cans of a beverage containing aspartame and acesulfame K over 12 wk has no significant effect on insulin sensitivity and secretion in nondiabetic adults. " 01/01/2018 - "This trial compared the effects of the consumption of a carbonated beverage containing aspartame and acesulfame K (high-intensity sweeteners beverage-HISB) with those of an unsweetened, no-calorie carbonated beverage (UB) on insulin sensitivity and secretion in nondiabetic adults. " 10/01/2019 - "Whether low-calorie sweeteners (LCS), such as sucralose and acesulfame K, can alter glucose metabolism is uncertain, particularly given the inconsistent observations relating to insulin resistance in recent human trials. "
5.	Neoplasms (Cancer) 10/01/2005 - "There were no neoplasms or nonneoplastic lesions that were attributed to exposure to acesulfame potassium. " 10/01/2005 - "There were no neoplasms or nonneoplastic lesions that were attributed to exposure to acesulfame potassium. " 01/01/2022 - "In particular, aspartame (HR = 1.15 [95% CI 1.03 to 1.28], P = 0.002) and acesulfame-K (HR = 1.13 [95% CI 1.01 to 1.26], P = 0.007) were associated with increased cancer risk. " 05/16/2018 - "Human Sweet Receptor T1R3 is Functional in Human Gastric Parietal Tumor Cells (HGT-1) and Modulates Cyclamate and Acesulfame K-Induced Mechanisms of Gastric Acid Secretion." 01/01/2022 - "In this large cohort study, artificial sweeteners (especially aspartame and acesulfame-K), which are used in many food and beverage brands worldwide, were associated with increased cancer risk. "

Related Drugs and Biologics

1.	Aspartame (NutraSweet)
2.	trichlorosucrose (sucralose)
3.	Saccharin
4.	Glucose (Dextrose)
5.	Glucagon-Like Peptide 1 (GLP 1)
6.	Sweetening Agents (Sweeteners)
7.	Cyclamates (Cyclamate)
8.	Non-Nutritive Sweeteners
9.	neohesperidin dihydrochalcone (neohesperidine dihydrochalcone)
10.	Serotonin (5 Hydroxytryptamine)