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avridine
Also Known As:
CP 20,961; CP 20961; CP-20,961; N,N-dioctyldecyl-N',N-bis(2-hydroxyethyl)propanediamine; avridine phosphate (2:1); N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)propanediamine
Networked:
33
relevant articles (
4
outcomes,
4
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Polyamines: 3918
Diamines: 518
avridine: 33
Experts
1.
Jones, Mark
: 1 article (10/2009)
2.
Whitehouse, Michael Wellesley
: 1 article (10/2009)
Related Diseases
1.
Arthritis (Polyarthritis)
09/01/1998 - "
We used the avridine arthritis rat model to evaluate the tissue response in the synovial, interstitial and subcutaneous tissues after implant insertion.
"
07/01/1995 - "
To investigate further the mechanisms behind the female preponderance, we selected the avridine induced arthritis model.
"
03/01/1995 - "
Nude rats are resistant to avridine-induced arthritis, indicating a T cell dependence of the disease which supports the importance of MHC.
"
03/01/1995 - "
To investigate a possible genetic influence on the disease we compared LEW, DA and E3 rats, which are of different genetic origins, for their ability to develop arthritis after injection of a low dose of avridine (1.5 mg/rat).
"
03/01/1995 - "
In LEW and DA rats the avridine-induced arthritis is severe and long lasting.
"
2.
Neoplasms (Cancer)
01/01/1984 - "
Further studies demonstrated that CP-20,961 protected mice against an ip challenge of P815 tumor cells as measured by survival time.
"
01/01/1986 - "
Avridine decreased the persistence of tumors when given one or five days after virus, but shortened the prepatent period and increased persistence if given one day prior to virus.
"
01/01/1984 - "
These data indicate that CP-20,961 affords protection against an ascitic mastocytoma tumor line and at least one, but not all, intracellular pathogens.
"
01/01/1986 - "
NK activity was greatly increased by virus at two days post-infection, and avridine given one day after infection significantly enhanced cytotoxicity of these splenic cells against tumor cells.
"
01/01/1986 - "
Pre-treatment by avridine had little effect on interferon levels over that induced by virus alone, but that did not explain the enhancement of tumor growth since NK activity was increased.(ABSTRACT TRUNCATED AT 250 WORDS)
"
3.
Experimental Arthritis
01/01/1998 - "
Moreover, nasal 176-190 led to similar arthritis protective effects in a non-microbially induced experimental arthritis (avridine induced arthritis).
"
03/01/1995 - "
The clinical appearance and histopathology of avridine-induced arthritis show great similarity to other arthritis models such as collagen-induced arthritis.
"
05/01/1996 - "
Hormones, particularly those involved in the hypothalamic-pituitary-gonadal and -adrenal axes (HPG and HPA), play important roles in various animal models of autoimmunity such as systemic lupus erythematosus in mice and collagen-induced arthritis (CIA) in mice and rats, and the streptococcal cell wall, adjuvant and avridine arthritis models in rats.
"
10/01/2009 - "
Thiocyanate supplements increased the severity of experimental arthritis induced by tailbase injection of (1) Freund's complete adjuvants (mycobacteria plus various adjuvant-active oils), (2) collagen type-II with Freund's incomplete adjuvant (no mycobacteria), (3) the synthetic lipid amine, avridine in an oil and (4) the natural hydrocarbons squalene (C(30)H(50)) and pristane (C(19)H(40)).
"
4.
Influenza in Birds (Avian Flu)
01/01/1992 - "
Enhancement of antibody response of turkeys to trivalent avian influenza vaccine by positively charged liposomal avridine adjuvant.
"
01/01/1992 - "
Efficacy of avridine and liposomes as adjuvants for avian influenza virus antigens in turkeys.
"
01/01/1992 - "
Four-week-old turkeys were vaccinated with H4N8, H5N2 and H7N3 inactivated avian influenza viruses (AIV) in one of the following adjuvants: avridine, positively charged liposomal avridine, liposomal avridine with covalent attachment to the AIV antigens and oil-emulsion; and without any adjuvant.
"
01/01/1992 - "
Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil-emulsion adjuvants when used in a trivalent avian influenza vaccine.
"
01/01/1992 - "
Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys.
"
5.
Mastocytoma
01/01/1984 - "
These data indicate that CP-20,961 affords protection against an ascitic mastocytoma tumor line and at least one, but not all, intracellular pathogens.
"
Related Drugs and Biologics
1.
Antigens
2.
Liposomes (Liposome)
3.
Leukocyte L1 Antigen Complex (Calgranulin)
4.
Interferons
5.
Therapeutic Uses
6.
Collagen Type II (Type II Collagen)
7.
Amines
8.
Vaccines
9.
Lipids
10.
Immunologic Factors (Immunomodulators)
Related Therapies and Procedures
1.
Intranasal Administration
2.
Injections