3- beta- (2- (diethylamino)ethoxy)androst- 5- en- 17- one

04/01/2007 - "In order to evaluate the efficacy of these two inhibitors in vivo, C57BL/6J mice inoculated with mouse-adapted scrapie-prion received repetitive intraperitoneal injections of U18666A (10 mg/kg) or a mixture of U18666A (10 mg/kg) and AY-9944 (12 mg/kg). "

02/01/1988 - "An ultrastructural analysis of plasma membrane in the U18666A cataract."
09/01/1985 - "Most of the animals treated with U18666A every other day beginning at one-day of age developed permanent nuclear cataracts by 3-4 weeks of age. "
06/01/2009 - "U18666A also provided animal models for two important disorders: petite mal (absence) epilepsy and cataracts. "
07/01/2004 - "Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor."
10/01/1988 - "Specific restriction of cholesterol from cortical lens gap junctional membrane in the U18666A cataract."

01/01/2013 - "From this screen we identified six compounds, including U18666A, that block EBOV infection (IC(50) 1.6 to 8.0 µM) at a late stage of entry. "
01/01/2012 - "We have shown in this study that dengue virus infection was affected when the cholesterol intake in infected cells was disrupted using a cholesterol transport inhibitor, U18666A. "
01/01/2022 - "Collectively, our data suggest that U18666A interferes with PRV infection via altering cellular functions that are critical for the viral life cycle and may include lysosomal cholesterol homeostasis."
01/01/2022 - "The Cholesterol Transport Inhibitor U18666A Interferes with Pseudorabies Virus Infection."
09/01/2017 - "The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection."

01/01/2017 - "U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells."
10/01/2008 - "We proposed to determine how U18666a regulates APP holoprotein metabolism and trafficking in N2a mouse neuroblastoma cells stably expressing the human APP protein. "
12/01/2006 - "When NO-catalyzed degradation of HS was depressed in mouse neuroblastoma cell line (N2a) by using 3-beta[2(diethylamino) ethoxy]androst-5-en-17-one (U18666A), both ascorbate and dehydroascorbic acid restored formation of anMan-positive products that colocalized with Rab7. "
01/01/1999 - "To determine if neurochemical function might be impaired in cell models with altered cholesterol balance, we studied the effects of U18666A (3-beta-[(2-diethyl-amino)ethoxy]androst-5-en-17-one) on intracellular cholesterol metabolism in three human neuroblastoma cell lines (SK-N-SH, SK-N-MC, and SH-SY5Y). "
01/01/1999 - "U18666A inhibits intracellular cholesterol transport and neurotransmitter release in human neuroblastoma cells."

11/01/2006 - "This review provides a consolidation of work done using U18666A in the past half century and focuses on the implications of our research findings on the mechanism of U18666A-mediated neuronal apoptosis in primary cortical neurons, which may provide an insight to elucidate the mechanisms of neurodegenerative diseases, particularly NPC and AD, where apoptosis might occur through a similar mechanism."
11/23/2023 - "U18666A has performed many functions, allowing for essential discoveries in lipid studies and shedding light on the pathophysiology of neurodegenerative disorders. "
11/23/2023 - "Potential Use of the Cholesterol Transfer Inhibitor U18666A as a Potent Research Tool for the Study of Cholesterol Mechanisms in Neurodegenerative Disorders."