budralazine

07/01/1989 - "Throughout the salt-loading period, oral administration of budralazine (1, 4 and 15 mg/kg/day) resulted in a dose-dependent inhibition of the accelerated hypertension. "
07/01/1989 - "These results suggest that budralazine attenuates the serious development of hypertension and reduces the incidence and severity of stroke in salt-loaded SHR."
09/01/1978 - "Budralazine was orally effective against various types of hypertension in rats and it, like reserpine but unlike hydralazine, produced a much greater pressure reduction in hypertensive than in normotensive rats. "

01/01/1991 - "These findings suggest that the central sympathoinhibitory action of budralazine may be responsible for the anti-tachycardic effect of budralazine and baroreceptor-mediated tachycardia occurred after high dose of budralazine."
01/01/1991 - "On the contrary, at dose of 5.0 mg/kg, budralazine produced a tachycardia accompanied with increases in both ICNA and ASNA. "
05/01/1989 - "On the contrary, at dose of 5.0 mg/kg, budralazine produced a tachycardia accompanied with increases in both cardiac sympathetic nerve activity. "
06/01/1987 - "Baroreceptor-mediated tachycardia occurred after high dose budralazine (5.0 mg/kg) administration in anesthetized rats."
05/01/1986 - "When budralazine was injected into the jugular vein of the donor dog, a hypotension was produced with slight tachycardia in a dose-related manner. "

01/01/1991 - "At doses of 0.5 and 1.0 mg/kg, budralazine induced bradycardia accompanied with a decrease in cardiac sympathetic nerve activity (ICNA). "
05/01/1989 - "At doses of 0.5 and 1.0 mg/kg, budralazine induced bradycardia accompanied with a decrease in cardiac sympathetic nerve activity. "
06/01/1987 - "At doses of 0.5 and 1.0 mg/kg, budralazine induced bradycardia accompanied with a decrease in cardiac sympathetic nerve activity. "
01/01/1981 - "As the dose was increased to 6 and 12 mg/kg i.v., however, budralazine not only inhibited transiently the sympathetic tachycardia but also enhanced the clonidine bradycardia, although this drug was almost without effect on resting heart rate. "
01/01/1981 - "Hydralazine (3 mg/kg i.v.) differed from budralazine in that its transient inhibition of the stimulation-induced tachycardia was not modified by phentolamine and it produced an acceleration of the recovery of clonidine bradycardia as well as an increase in resting heart rate. "

12/01/1989 - "However, 9 weeks of treatment with the low dose (19-27 mg/kg/day) of budralazine, which produced moderate continuous hypotension in nine rats, did not apparently influence the lower limit. "
05/01/1986 - "When budralazine was injected into the jugular vein of the donor dog, a hypotension was produced with slight tachycardia in a dose-related manner. "

07/01/1989 - "These results suggest that budralazine attenuates the serious development of hypertension and reduces the incidence and severity of stroke in salt-loaded SHR."