carcainium chloride

10/01/2016 - "To determine the effectiveness of aerosolised carcainium chloride (VRP700) in controlling cough in patients with IIP. "
10/01/2016 - "Studies in animals suggest that carcainium chloride, a quaternary derivative of the local anesthetic lidocaine, is able to inhibit experimentally induced cough by a mechanism of action distinct from that of lidocaine. "
02/01/2003 - "3 Acute pre-treatment of guinea-pigs with aerosols of lidocaine or RSD931 at 10.0 and 30.0 mg ml(-1) reduced the number of capsaicin-evoked coughs by 42.2 and 10.3% (P>0.05) (lidocaine) and by 25% (P>0.05) and 76.9% (P<0.01) (RSD931), respectively. "
02/01/2003 - "In addition, RSD931 at 10 mg ml(-1) reduced citric acid-evoked cough responses in rabbits (with prior exposure to ozone at 3 p.p.m. "
02/01/2003 - "2 Pre-treatment of guinea-pigs with aerosols of lidocaine or RSD931 at 0.1, 1.0 and 10 mg ml(-1) reduced the number of citric acid-induced coughs by 9.3, 32.6 and 40.9% (P>0.05) for lidocaine and by 25.3% (P>0.05), 40.4% (P>0.05) and 97.6% (P<0.01) for RSD931, respectively and increased the latency to onset of cough at 10.0 mg ml(-1) only. "

01/01/1984 - "The results of experimental as well as clinical investigations indicate that the effects of lidocaine and QX-572 on tinnitus are mediated by a peripheral mechanism possibly related to their accumulation on inner ear melanin."
01/01/1984 - "To elucidate the question whether lidocaine reduces tinnitus by a central or by a peripheral mechanism of action, its effect on tinnitus was compared with that of QX-572, a quaternary ammonium derivative of lidocaine which does not readily penetrate the blood-brain barrier. "
01/01/1984 - "To elucidate the possible role of melanin affinity in pharmacological treatment of tinnitus and the site of action of lidocaine and tocainide, nine patients with disabling tinnitus were treated with lidocaine, QX-572 (a quaternary derivative of lidocaine which does not readily penetrate the blood-brain barrier) and tocainide (an amine analogue of lidocaine which can be taken orally). "

04/04/1975 - "A second group of 28 patients with acute myocardial infarction also received QX-572 8 mg/kg body wt. Their plasma levels did not differ significantly from those found in the first group of patients. "
01/01/1978 - "Lidocaine and the quarternary ammonium compound QX-572 in acute myocardial infarction. "
01/01/1978 - "Patients with suspected or proven acute myocardial infarction complicated by ventricular arrhythmias not corrected by lidocaine therapy (bolus dose 100 mg followed by infusion 2 mg/min) were treated either with an increased dose of lidocaine (bolus dose 50 mg followed by infusion 3 mg/min) or with 600 mg N,N-bis dimethylammonium chloride (QX-572, Astra, Sweden) as an i.v. infusion during 30 min (3 patients) or 60 min (13 patients). "

01/01/1975 - "The antiarrhythmic agent, N,N-bis(phenylcarbamoylmethyl)dimethylammonium chloride (QX-572) 8 mg/kg body weight produced a decreased conduction time through the atrioventricular node but did not influence intra-atrial or intraventricular conduction. "
01/01/1975 - "It was concluded that QX-572 in a dose of 8 mg/kg body weight did not have any major haemodynamic drawbacks."
01/01/1975 - "Ten patients with mild to moderate aortic regurgitation were studied: based on clinical data the patients were divided into 2 groups of 5. Randomly it was decided that one group should constitute a control group receiving saline while the second group received QX-572 , MG/KG BODY WEIGHT. "

10/01/2016 - "Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study."