R388 (R-factor)

drug-resistant form of enzyme, dihydrofolate reductase, biosynthesized by E coli that confers resistance to trimethoprim; increases resistance by 10,000 fold & mediates synthesis of additional dihydrofolate reductase which is 20,000x less susceptible to trimethoprim inhibition; do not confuse with Cat. G heading R FACTORS

Also Known As:

Networked: 69 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schry, Amie R: 1 article (05/2014)
2.	White, Susan W: 1 article (05/2014)
3.	Smith, Laura A: 1 article (05/2014)
4.	Yamada, Shozo: 1 article (04/2014)
5.	Nakano-Tateno, Tae: 1 article (04/2014)
6.	Hlaing, Maw Maw: 1 article (04/2014)
7.	Yoshimoto, Katsuhiko: 1 article (04/2014)
8.	Zheng, Lei: 1 article (04/2014)
9.	Asa, Sylvia L: 1 article (04/2014)
10.	Tateno, Toru: 1 article (04/2014)

Related Diseases

1.	Starvation 08/01/1989 - "Strains of enteric bacteria and pseudomonads containing plasmid R388::Tnl721 (Tpr, Tcr) or pRO101 (Hgr, Tcr) were starved for over 250 days in sterile well water to evaluate effects of starvation-survival on plasmid expression and maintenance. " 08/01/1972 - "R factor 1818 is shown to be eliminated from a thymineless strain of Escherichia coli J6-2 (R-1818) during thymine starvation. " 06/01/1974 - "The maximal level of R-factor elimination produced by thymine starvation was inversely related to the ligase level of the host. " 08/01/1972 - "R factor elimination during thymine starvation: effects of inhibition of protein synthesis and readdition of thymine." 10/01/1971 - "R-factor elimination by thymine starvation."
2.	Dysentery 10/01/1980 - "The study on 198 Shigella strains isolated from dysentery patients and cultures from 3 different dysentery foci showed a possibility of intraspecies typing of the causative agents according to the R factor incompatibility groups with regard to the antibiotic resistance spectra. " 11/01/1972 - "[Types and frequency of R-factor carriage in intestinal bacilli isolated from patients with acute dysentery]." 01/01/1971 - "Acceptance of R factor by a Shigella sonnei strain from commensal Escherichia coli strains during dysentery." 11/01/1970 - "[Incidence of R-factor carrier state among Shigella strains isolatid from dysentery patients]." 04/01/1970 - "[Oxidoreductase activity in dysentery bacteria having acquired the R-factor in in vitro experiments]."
3.	Urinary Tract Infections (Urinary Tract Infection) 06/01/1994 - "Transferable drug resistance (R-factor) among the enterobacteriaceae in urinary tract infections: a study at an urban hospital in Bangladesh." 03/01/1984 - "[R factor in urinary tract infection]." 11/01/1973 - "Incidence of resistance transfer factor (R factor) among enterobacteriaceae in urinary tract infections." 05/01/1989 - "Nitrofurantoin is being "rediscovered" for urinary tract infections in obstetrics and gynecology because of its continuing safety record and lack of associated R-factor resistance, compared to recently introduced antimicrobials." 01/01/1967 - "[Distribution of antigen types and the maintenance of R factor in Escherichia coli isolated from the urine of the patients with urinary tract infections]."
4.	Infection 12/01/1983 - "The ability of Klebsiella spp. readily to colonize hospitalized patients, complications in treatment of infections due to R-factor-acquired antibiotic resistance, and the high mortality rate in certain patient populations, point to the need for immunoprophylactic/immunotherapeutic agents for disease control. " 03/01/1979 - "Effect of a Salmonella group H1 R factor on virulence and response of infections to antimicrobial therapy." 07/01/1972 - "The infection of different Hfr strains of Escherichia coli bearing derepressed R factors of the fi(+) or fi(-) type can result in the loss of the R factor and the conversion of the infected cells to the R(-) state. " 05/01/1970 - "All col factors, however, were not equally susceptible to elimination by the R factors tested, since colicin production in ML strains was abolished by infection by the 222 factor but not by the R factor of S. " 12/01/1967 - "R factor infection of Escherichia coli lyophilized in 1946."
5.	Superinfection 11/01/1968 - "The absence of superinfection immunity in transduction may be due to the difference in the route of entry of the R factor. " 11/01/1965 - "It appears that the resistance region of the R factor has replaced that portion of phage genome which is essential for vegetative replication and superinfection immunity. " 07/01/1962 - "1962.-When two types of R factor, R(TC) and R (CM.SM.SA), or R(TC) and R (CM), were brought together in a host bacterium by superinfection with both factors, loss of either one or both factors was found. " 01/01/1962 - "Superinfection of a host bacterium with 2 R factor]." 09/01/1973 - "Superinfection of an Escherichia coli R(+) strain with a closely related R-factor was associated with the accumulation of replicative intermediates of the superinfecting deoxyribonucleic acid. "

Related Drugs and Biologics

1.	Thymine
2.	Trimethoprim (Proloprim)
3.	Chloramphenicol (Chloromycetin)
4.	Ampicillin (Omnipen)
5.	DNA (Deoxyribonucleic Acid)
6.	Streptomycin (Streptomycin Sulfate)
7.	Kanamycin
8.	Gentamicins (Gentamicin)
9.	Antigens
10.	Tetracycline (Achromycin)

Related Therapies and Procedures

1.	Catheters
2.	Refractive Surgical Procedures
3.	Intensive Care (Surgical Intensive Care)
4.	Intraocular Lenses (Intraocular Lens)
5.	Drug Therapy (Chemotherapy)