R388 (R-factor)

drug-resistant form of enzyme, dihydrofolate reductase, biosynthesized by E coli that confers resistance to trimethoprim; increases resistance by 10,000 fold & mediates synthesis of additional dihydrofolate reductase which is 20,000x less susceptible to trimethoprim inhibition; do not confuse with Cat. G heading R FACTORS

Also Known As:

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tateno, Toru: 2 articles (01/2016 - 04/2014)
2.	Jalali, Shahrzad: 1 article (01/2016)
3.	Monsalves, Eric: 1 article (01/2016)
4.	Zadeh, Gelareh: 1 article (01/2016)
5.	Schry, Amie R: 1 article (05/2014)
6.	Smith, Laura A: 1 article (05/2014)
7.	White, Susan W: 1 article (05/2014)
8.	Asa, Sylvia L: 1 article (04/2014)
9.	Ezzat, Shereen: 1 article (04/2014)
10.	Hlaing, Maw Maw: 1 article (04/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "More importantly, GH activity was significantly reduced after mTOR inhibition in the R388 polymorphic variant tumors. " 01/01/2016 - "Histological analysis revealed that prototypic FGFR4 (G388) tumors express increased prolactin and less GH, whereas tumors possessing the polymorphic variant of FGFR4 (R388) express increased GH relative to prolactin. " 06/01/2006 - "Clinical investigations of an FGFR4 germline polymorphism, resulting in substitution of glycine by arginine at codon 388 (G388 to R388), have shown a correlation between FGFR4 R388 and aggressive disease progression in cancer patients. "
2.	Disease Progression 06/01/2006 - "Therefore, the positive effect of FGFR4 R388 on disease progression appears to result from a loss of the tumour suppressor activity displayed by FGFR4 G388 rather than the acquisition or enhancement of oncogenic potential." 06/01/2006 - "Clinical investigations of an FGFR4 germline polymorphism, resulting in substitution of glycine by arginine at codon 388 (G388 to R388), have shown a correlation between FGFR4 R388 and aggressive disease progression in cancer patients. "
3.	Whooping Cough (Pertussis) 04/01/1994 - "Similar amino acid sequences of the conjugative transfer genes of F, R388 as well as plasmid RP4 and the genes of the ptI operon of Bortedella pertussis suggest the existence of a superfamily of transmembrane proteins adapted to the promiscuous transfer of DNA-protein complexes."
4.	Starvation 08/01/1989 - "Strains of enteric bacteria and pseudomonads containing plasmid R388::Tnl721 (Tpr, Tcr) or pRO101 (Hgr, Tcr) were starved for over 250 days in sterile well water to evaluate effects of starvation-survival on plasmid expression and maintenance. "
5.	Pituitary Neoplasms (Pituitary Adenoma) 04/01/2014 - "Moreover, clinical data from patients with pituitary tumors revealed that those homozygous for the R388 allele have a higher frequency of silent corticotroph macroadenomas than FGFR4-G388 carriers, who were more likely to have small but hormonally active microadenomas. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Prolactin
3.	Glycine (Aminoacetic Acid)
4.	DNA (Deoxyribonucleic Acid)
5.	Codon (Codons)
6.	Arginine (L-Arginine)