C 27 (C-27)

rifamycin SV with dicyclohexylalkyl-substituted piperidyl ring at 3-position; inhibitor of nucleic acid polymerases

Also Known As:

C-27; 3-(4-(dicyclohexylmethyl)-1-piperidinyl)rifamycin

Networked: 61 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Rifamycins: 416
      - C 27: 61
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Macrocyclic Lactams: 28
    - Rifamycins: 416
      - C 27: 61

Experts

1.	Bukhary, Hashem: 1 article (11/2022)
2.	Kim, Il Su: 1 article (11/2022)
3.	Kim, Kyoung Ho: 1 article (11/2022)
4.	Kim, Su Cheol: 1 article (11/2022)
5.	Lee, Sang Min: 1 article (11/2022)
6.	Park, Jong Hun: 1 article (11/2022)
7.	Yoo, Jae Chul: 1 article (11/2022)
8.	Fujita, Nobuyuki: 1 article (11/2021)
9.	Hosogane, Naobumi: 1 article (11/2021)
10.	Ishii, Ken: 1 article (11/2021)

Related Diseases

1.	Fistula 01/25/1981 - "In vivo studies were carried out on three bile fistula patients to further elucidate the side chain oxidation pathways from C-27 bile acids to cholic acid in man. " 10/01/1971 - "The formation and metabolism of a naturally occurring C(27) bile acid, 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid, was studied in patients with T-tube bile fistulas. "
2.	Pituitary ACTH Hypersecretion 01/01/2019 - "The study included control (C = 27), paired (P = 16) and Cushing's disease (CD = 10) groups, which underwent biochemical assessment, dual X-ray absorptiometry, TBS, and magnetic resonance imaging to determine fat deposits. "
3.	Nephrotic Syndrome (Syndrome, Nephrotic) 12/01/2004 - "While an extensive amount of data is available in adult nephrotic syndrome in which statin therapy decreases total plasma cholesterol 22-39%, low-density lipoprotein cholesterol (LDL-C) 27-47%, and total plasma triglycerides 13-38%, only 2 small uncontrolled studies have been conducted evaluating the utility of these agents in pediatric nephrotic syndrome. "
4.	Type 2 Diabetes Mellitus (MODY) 09/01/2007 - "Data from the Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER 2) study in patients with established CHD and low HDL-C (27% of whom had type 2 diabetes) show the atheroprotective effects of nicotinic acid/statin combination therapy. "
5.	Infections 01/01/2016 - "The gC- mutant virus produced plaques that were similar in size to those resulting from infection with the C-27 parent strain. " 12/01/2001 - "Risk factors for infection were assessed by a serological survey in 1999, which revealed a seroprevalence of (a) 86% in people who had close contact with sick geese, (b) 28% in people in areas along bird migration routes, and (c) 27% in the general population. " 01/01/2003 - "Of note chest and urinary tract infection (R 6%, C 11%, P <0.02) and "any" infection (R 20%, C 27%, P <0.05) were reduced with ceftriaxone. "

Related Drugs and Biologics

1.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
2.	Cholesterol
3.	Bile Acids and Salts (Bile Acids)
4.	Cholic Acid
5.	Triglycerides (Triacylglycerol)
6.	Niacin (Nicotinic Acid)
7.	LDL Cholesterol
8.	oxidized low density lipoprotein
9.	Acids
10.	Gonadotropin-Releasing Hormone (GnRH)

Related Therapies and Procedures

1.	Therapeutics
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Operative Time
4.	Cystectomy
5.	Transplantation