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NK 2 (NK-2)

Also Known As:

NK-2; 3-nitro-4-hydroxybenzyl 2,4-dichlorophenoxyacetate; (2,4-dichlorophenoxy)acetic acid, (4-hydroxy-3-nitrophenyl)methyl ester

Networked: 43 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Glycolates
      - Phenoxyacetates: 2
        2,4-Dichlorophenoxyacetic Acid: 221
        NK 2: 43
  - Acyclic Acids
    - Acetates: 4994
      - Glycolates
        Phenoxyacetates: 2
        2,4-Dichlorophenoxyacetic Acid: 221
        NK 2: 43

Experts

1.	Andrä, Jörg: 5 articles (04/2013 - 11/2005)
2.	Advenier, C: 3 articles (06/2001 - 05/2000)
3.	Giuliani, Sandro: 2 articles (05/2009 - 08/2008)
4.	Meini, Stefania: 2 articles (05/2009 - 08/2008)
5.	Jacobs, Thomas: 2 articles (05/2008 - 02/2003)
6.	Leippe, Matthias: 2 articles (05/2008 - 02/2003)
7.	Emonds-Alt, X: 2 articles (06/2001 - 05/2000)
8.	Lagente, V: 2 articles (06/2001 - 05/2000)
9.	Dodam, John R: 1 article (02/2016)
10.	Grobman, Megan: 1 article (02/2016)

Related Diseases

1.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 08/15/2008 - "NK(2) antagonists have been reported to be potentially useful for the treatment of a number of chronic diseases, such as asthma, irritable bowel syndrome, cystitis, and depression. " 02/01/2003 - "The neurokinin (NK) receptors, NK(1) and NK(2), which are activated by substance P (SP) and NKA, have been identified as potential therapeutic targets in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). " 05/01/2009 - "Ibodutant (MEN15596, [1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) is a tachykinin NK(2) receptor (NK(2)R) antagonist currently under phase II clinical trials for irritable bowel syndrome. "
2.	Asthma (Bronchial Asthma) 08/15/2008 - "NK(2) antagonists have been reported to be potentially useful for the treatment of a number of chronic diseases, such as asthma, irritable bowel syndrome, cystitis, and depression. " 02/01/2016 - "Tachykinins released from sensory nerves and immune cells binding neurokinin (NK)-1, NK-2 and NK-3 receptors have been implicated in asthma pathogenesis. "
3.	Cystitis 08/15/2008 - "NK(2) antagonists have been reported to be potentially useful for the treatment of a number of chronic diseases, such as asthma, irritable bowel syndrome, cystitis, and depression. "
4.	Chronic Disease (Chronic Diseases) 08/15/2008 - "NK(2) antagonists have been reported to be potentially useful for the treatment of a number of chronic diseases, such as asthma, irritable bowel syndrome, cystitis, and depression. "
5.	Respiratory Hypersensitivity 10/19/2001 - "Preclinical studies have indicated a role for the tachykinin NK(1), NK(2) and NK(3) receptors in bronchoconstriction, airway hyperresponsiveness and airway inflammation caused by allergic and nonallergic stimuli. " 05/01/2000 - "The rank order of potency was: [betaAla(8)]NKA (4-10)>NKA=NKB=senktide=[MePhe(7)]NKB=[Sar(9),Met(0(2))(11)]SP>SP. 3. Airway hyperresponsiveness induced by [MePhe(7)]NKB was prevented by the tachykinin NK(3) (SR 142801) and NK(2) (SR 48968) receptor antagonists. "

Related Drugs and Biologics

1.	Tachykinins
2.	Substance P
3.	Peptides (Polypeptides)
4.	Neurokinin-1 Receptors (Neurokinin 1 Receptor)
5.	Neurokinin-3 Receptors
6.	Neurokinin-2 Receptors (Neurokinin 2 Receptor)
7.	Amides
8.	ibodutant
9.	6-methylbenzo(b)thiophene-2-carboxylic acid (1- (2- phenyl- ((1- (tetrahydropyran- 4- ylmethyl)piperidin- 4- ylmethyl)carbamoyl)ethylcarbamoyl)cyclophenyl)amide
10.	Neurokinin A