methidathion (S- 2,3- dihydro- 5- methoxy- 2- oxo- 1,3,4- thiadiazol- 3- ylmethyl O,O-dimethyl phosphorodithioate)

widely used on citrus, tobacco, alfalfa, cotton, sorghum & several other crops

Also Known As:

S-2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl O,O-dimethyl phosphorodithioate; GS 13005; O,O-dimethyl S-(2-methoxy-1,3,4-thiadiazole-5)-(4H)-onyl-(4)-methylphosphorodithioate; S-(5-methoxy-2-oxo-1,3,4-thiadiazol-3-(2H)-yl) O,O-dimethylphosphorodithioate; Supracide; metidathion

Networked: 17 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organothiophosphorus Compounds
    - methidathion: 17
- Sulfur Compounds: 278
  - Organothiophosphorus Compounds
    - methidathion: 17

Experts

1.	Chorley, Brian N: 1 article (01/2022)
2.	Corton, J Christopher: 1 article (01/2022)
3.	George, Barbara Jane: 1 article (01/2022)
4.	Hester, Susan D: 1 article (01/2022)
5.	Hughes, Michael F: 1 article (01/2022)
6.	Kenyon, Elaina M: 1 article (01/2022)
7.	Rooney, John: 1 article (01/2022)
8.	Ryan, Natalia: 1 article (01/2022)
9.	Schmid, Judith E: 1 article (01/2022)
10.	Sey, Yusupha M: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "The OP methidathion was previously shown to increase the incidence of liver toxicity, including hepatocellular tumors, in male mice. " 10/01/1990 - "Methidathion was categorized as a Group C (possible human) carcinogen based upon evidence of an increased incidence of benign and malignant hepatocellular tumors, alone and in combination, in a single study involving male Chr-CD-1 mice. " 12/01/2002 - "Lifetime cancer risks of one-in-a-million or greater were estimated for 50% of the exposed population for 1,3-dichloropropene (1990 monitoring) and 25% of the exposed populations for methidathion and molinate. " 01/01/2022 - "To provide insights into the adverse outcome pathway (AOP) that underlies these tumors, effects of methidathion in the male mouse liver were examined after 7 and 28 day exposures and compared to those of two other OPs that either do not increase (fenthion) or possibly suppress liver cancer (parathion) in mice. "
2.	Poisoning 11/01/2017 - "Methidathion Poisoning." 08/01/2009 - "Homicidal poisoning by injection of methidathion: the first ever report." 11/01/1990 - "Acute poisoning with methidathion: a case." 09/01/2012 - "From the toxicological data together with autopsy findings, the cause of his death was diagnosed as acute poisoning by an emulsion of methidathion." 09/01/2002 - "According to the autopsy finding and toxicological analysis, the cause of death was judged to be acute trichlorfon and methidathion poisoning."
3.	Cardiotoxicity 08/01/2023 - "Taken together, the results in this work illustrated that methidathion caused developmental toxicity, cardiotoxicity, and immunotoxicity in embryogenetic zebrafish." 08/01/2023 - "Developmental toxicity, immunotoxicity and cardiotoxicity induced by methidathion in early life stages of zebrafish." 07/01/2004 - "Cardiotoxicity in rats induced by methidathion and ameliorating effect of vitamins E and C."
4.	Organophosphate Poisoning 09/01/2012 - "High concentration of methidathion detected in a fatal case of organophosphate-poisoning."
5.	Weight Gain 10/01/2010 - "Methidathion causes low weight gain and deaths among pregnant rats, increases intrauterine fetus deaths, causes low birth weights in the newborns, and histopathological changes in the lung tissues of newborn rats. "

Related Drugs and Biologics

1.	Carcinogens
2.	Parathion (Ethyl Parathion)
3.	Malathion (Karbofos)
4.	Fenthion
5.	Dichlorvos
6.	Diazinon (Dimpylate)
7.	Organophosphates
8.	Fenitrothion
9.	Chlorpyrifos (Lorsban)
10.	Vitamins