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6-thioguanosine

RN given refers to cpd without isomeric designation

Also Known As:

2-amino-9-beta-D-ribofuranosyl-9H-purine-6-thiol; 6-mercaptoguanosine; 6-thioguanosine, (beta-D)-isomer

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Crespo-Hernández, Carlos E: 1 article (03/2011)
2.	Guo, Cao: 1 article (03/2011)
3.	Reichardt, Christian: 1 article (03/2011)
4.	Abel-Santos, Ernesto: 1 article (04/2007)
5.	Akoachere, Monique: 1 article (04/2007)
6.	Angelov, Ludmyl: 1 article (04/2007)
7.	Brojatsch, Jürgen: 1 article (04/2007)
8.	Nour, Adel M: 1 article (04/2007)
9.	Squires, Raynal C: 1 article (04/2007)
10.	Eichelbaum, Michel: 1 article (10/2005)

Related Diseases

1.	Crohn Disease (Crohn's Disease) 10/01/2005 - "Azathioprine is the gold standard for immunosuppressive therapy in Crohn's disease (CD) and its molecular mechanism of action is caused by the metabolite 6-thioguanosine triphosphate (TGTP). " 10/01/2005 - "6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease."
2.	Liver Cell Adenoma (Hepatocellular Adenoma) 07/01/1984 - "The effects of 50% lethal doses of three purine analogues, 6-methylmercaptopurine riboside ( MMPR ), 6-thioguanosine (TGR), and 6- selenoguanosine ( SeGR ), on mitotic activity in a slow-growing ( SS1H ) and a fast-growing ( BH3 ) transplantable hepatocellular adenoma in C3H/ StW and BUB mice, respectively, were analyzed statistically. "
3.	Phototoxic Dermatitis (Phototoxicity) 03/31/2011 - "The high triplet yield of 6-thioguanosine, which we argue can result in photosensitization of molecular oxygen and photooxidative DNA damage, is proposed to explain the high phototoxicity exhibited by these pro-drugs in patients upon sunlight exposure. " 03/31/2011 - "In this contribution the photophysics of 6-thioguanosine have been studied in aqueous buffer solution and in acetonitrile after excitation with UVA light to provide mechanistic insights about the origin of its phototoxicity. "
4.	Sarcoma 180 01/01/1969 - "II. Inhibition by 6-thioguanosine 5'-phosphate of the enzyme isolated from hog brain and sarcoma 180 ascites cells."
5.	Photosensitivity Disorders (Photodermatitis) 03/31/2011 - "The high triplet yield of 6-thioguanosine, which we argue can result in photosensitization of molecular oxygen and photooxidative DNA damage, is proposed to explain the high phototoxicity exhibited by these pro-drugs in patients upon sunlight exposure. "

Related Drugs and Biologics

1.	Azathioprine (Imuran)
2.	triphosphoric acid (triphosphate)
3.	Tubercidin
4.	Toyocamycin
5.	Solutions
6.	Ribosomal RNA
7.	Diphosphates (Pyrophosphates)
8.	Prodrugs
9.	Oxygen (Dioxygen)
10.	Methylthioinosine

Related Therapies and Procedures

1.	Therapeutics