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proxymetacaine (Alcaine)

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RN given refers to parent cpd; structure

Also Known As:

Alcaine; Ophthaine; Ophthetic; proparacaine; AK-Taine; Akorn brand of proxymetacaine hydrochloride; Alcon brand of proxymetacaine hydrochloride; Allergan brand of proxymetacaine hydrochloride; Chauvin brand of proxymetacaine hydrochloride; Chibret brand of proxymetacaine hydrochloride; Chibro-Kerakain; Kainair; Kéracaine; Minims Proxymetacaine Hydrochloride; Ocu-Caine; Ocumed brand of proxymetacaine hydrochloride; Ocusoft brand of proxymetacaine hydrochloride; Parcaine; Pharmafair brand of proxymetacaine hydrochloride; Proparakain-POS; Ursapharm brand of proxymetacaine hydrochloride; proxymetacaine hydrochloride; proxymetacaine monohydrochloride; 3-amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester

Networked: 56 relevant articles (7 outcomes, 6 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Benzoic Acids: 18
      - Aminobenzoic Acids
        4-Aminobenzoic Acid: 376
        Propoxycaine
        proxymetacaine: 56

Experts

1.	Mifflin, Mark D: 2 articles (04/2015 - 01/2014)
2.	Joshi, Rajesh Subhash: 2 articles (07/2014 - 07/2013)
3.	Milne, Ken: 1 article (11/2015)
4.	Swaminathan, Anand: 1 article (11/2015)
5.	Otterness, Karalynn: 1 article (11/2015)
6.	Rezaie, Salim: 1 article (11/2015)
7.	Brennan, Kevin C: 1 article (04/2015)
8.	Kinard, Krista I: 1 article (04/2015)
9.	Lessard, Margaret K: 1 article (04/2015)
10.	Katz, Bradley J: 1 article (04/2015)

Related Diseases

1.	Pain (Aches) 06/01/2011 - "Most studies supported the use of topical proparacaine, which marginally decreased pain without any side effects. " 09/01/2010 - "Pain reduction was significantly better in the proparacaine group than in the placebo group, with a median improvement of 3.9 (interquartile range [IQR] 1.5-5.1) cm on the visual analog scale versus a median improvement of 0.6 (IQR 0.2-2.0) cm (p = 0.007). " 01/01/2009 - "The patient was initially seen in an emergency department where she was given a bottle of topical anesthetic drops (proparacaine) to use for pain. " 08/01/1997 - "Dilute (0.05%) topical proparacaine is nonanesthetic and nontoxic, and can be used safely for at least 1 week to reduce pain after PRK." 08/01/1997 - "Part II: In a prospective, double-masked study, 34 patients who underwent PRK (48 eyes) self-administered either topical 0.05% proparacaine or placebo for 1 week after PRK as needed to reduce pain. "
2.	Cataract (Cataracts) 07/01/2013 - "The purpose of this study was to compare the efficacy of a single drop of 0.5% proparacaine hydrochloride in uncomplicated cataract surgery with phacoemulsification. " 07/01/2013 - "An equal number of patients in both groups preferred same type of anesthetic technique for the fellow eye cataract surgery (89.11% for the proparacaine group and 90.18% for the xylocaine group). " 07/01/2013 - "A single drop pre-operatively, of proparacaine hydrochloride was comparable to the intracameral supplementation of preservative free xylocaine for phacoemulsification in uncomplicated cataract surgery without compromising the visual outcome. " 10/01/1998 - "To evaluate the use of proparacaine (Proxymetacaine) versus tetracaine (Amethocaine) as the topical anesthetic agent for phacoemulsification cataract surgery using a 3.5 mm clear corneal sutureless incision. " 11/01/2003 - "Before cataract surgery at our institution, we traditionally dilated the pupils with 5 drops: proparacaine 0.5%, cyclopentolate 1%, phenylephrine 2.5%, flurbiprofen sodium 0.03% (Ocufen), and ofloxacin 0.3% (Ocuflox) at 15-minute intervals given 3 times. "
3.	Wounds and Injuries (Trauma) 09/01/2010 - "We compared the analgesic efficacy of dilute topical proparacaine with placebo in emergency department patients with acute corneal injuries. " 07/01/2011 - "Re: Dilute proparacaine for the management of acute corneal injuries in the emergency department. " 09/01/2010 - "Dilute topical proparacaine is an efficacious analgesic for acute corneal injuries. " 09/01/2010 - "Dilute proparacaine for the management of acute corneal injuries in the emergency department."
4.	Retinopathy of Prematurity (Retrolental Fibroplasia) 02/01/2015 - "Compare efficacy of 0.5% proparacaine eye drops and oral 25% dextrose in reducing pain during screening for retinopathy of prematurity (ROP). "
5.	Strabismus (Squint) 01/01/2006 - "Intraoperative subtenon 2% lidocaine and topical 0.5% proparacaine in patients undergoing strabismus surgery were compared. " 01/01/2006 - "Subtenon lidocaine vs topical proparacaine in adult strabismus surgery." 07/01/2013 - "We conducted a randomised trial comparing lidocaine 2% gel with proparacaine 0.5% eye drops in children having elective squint surgery. " 07/01/2013 - "A randomised comparison of lidocaine 2% gel and proparacaine 0.5% eye drops in paediatric squint surgery." 07/01/2013 - "We conclude that, compared with proparacaine 0.5% eye drops, a single application of lidocaine 2% gel improves peri-operative analgesia and reduces the incidence of postoperative nausea and vomiting in elective paediatric squint surgery."

Related Drugs and Biologics

1.	Ophthalmic Solutions (Eye Drops)
2.	ROP
3.	Sucrose (Saccharose)
4.	Flurbiprofen (Froben)
5.	Glucose (Dextrose)
6.	Lidocaine (Xylocaine)
7.	Tropicamide
8.	Tetracaine (Amethocaine)
9.	proxymetacaine (Alcaine)
10.	Ofloxacin (Levofloxacin)

Related Therapies and Procedures

1.	Phacoemulsification
2.	Intravitreal Injections
3.	Photorefractive Keratectomy
4.	Lenses
5.	Anesthesia