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sanguinarine

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bactericidal produces glaucoma in laboratory animals; from Argemonemexicana & Sanguinaria; inhibits glutamate decarboxylase; structure

Also Known As:

Veadent; Viadent; pseudo-chelerythrine; pseudochelerythrine; sanguinarin; sanguinarine chloride; sanguinarine hydroxide; sanguinarine nitrate; sanguinarine sulfate (1:1); sanguinarine sulfate (2:1); sanguiritrin; sangvinarin

Networked: 134 relevant articles (6 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60

Experts

1.	Choi, Yung Hyun: 7 articles (07/2013 - 09/2007)
2.	Ahmad, Nihal: 5 articles (04/2015 - 08/2003)
3.	Han, Min Ho: 5 articles (07/2013 - 09/2007)
4.	Kim, Gi-Young: 5 articles (07/2013 - 01/2008)
5.	Das, Mukul: 5 articles (01/2013 - 12/2004)
6.	Ansari, Kausar M: 5 articles (01/2013 - 12/2004)
7.	Lee, Won Ho: 4 articles (11/2009 - 09/2007)
8.	Ulrichová, Jitka: 4 articles (06/2009 - 01/2004)
9.	Ulrichová, J: 4 articles (05/2007 - 01/2003)
10.	Li, Weifeng: 3 articles (10/2014 - 08/2012)

Related Diseases

1.	Gingivitis 11/01/1985 - "The results demonstrated that the Sanguinarine-containing mouthrinse was effective in reducing plaque formation and retarding the development of gingivitis." 04/01/1990 - "[Evaluation of the efficacy of sanguinarine using the experimental gingivitis model]." 08/01/1990 - "A critical comparison of the numerous clinical studies on sanguinarine indicates an extreme divergence of reported effects on plaque/gingivitis, ranging from significant reductions to findings of no detectable effect. " 11/01/1988 - "The findings of this study would suggest that the Veadent mouthrinse would at most only have a limited rôle as an inhibitor of plaque and gingivitis." 06/01/1996 - "The in vitro cytotoxicity of sanguinarine chloride, a dental product used in the treatment of gingivitis and plaque, was compared using cell lines and primary cells from oral human tissues. "
2.	Prostatic Neoplasms (Prostate Cancer) 04/01/2006 - "The aim of this study was to investigate whether expression of Cox-2 is effective against prostate cancer cell apoptosis triggered by sanguinarine, the quaternary benzophenanthridine alkaloid with antineoplastic properties. " 01/01/2012 - "In this study, we identified sanguinarine as a potent inhibitor of Stat3 activation which was able to suppress prostate cancer growth, migration, and invasion. " 01/01/2012 - "These data demonstrate that sanguinarine is a potent Stat3 inhibitor and it could be developed as a therapeutic agent for prostate cancer with constitutive activation of Stat3." 01/01/2012 - "Sanguinarine inhibits constitutive as well as IL6-induced phosphorylation of Stat3 at both Tyr705 and Ser727 in prostate cancer cells. " 01/01/2012 - "Sanguinarine, a benzophenanthridine alkaloid derived primarily from the bloodroot plant, was identified previously as a novel inhibitor of survivin that selectively kills prostate cancer cells over "normal" prostate epithelial cells. "
3.	Melanoma (Melanoma, Malignant) 05/01/2015 - "At 2 hours, sang-np killed a portion of melanoma cells, increasing to percentages comparable to free sanguinarine by 24 hours. " 05/01/2015 - "To exploit sanguinarine's observed activity against melanoma, a targeted delivery system is required. " 05/01/2015 - "However, when used in a controlled fashion, sanguinarine imparts selective cytotoxic/anti-proliferative activity through multiple mechanisms against human/ murine melanoma. " 05/01/2015 - "Characterization and assessment of nanoencapsulated sanguinarine chloride as a potential treatment for melanoma." 04/05/2013 - "Taking together, our data indicate that sanguinarine is a very rapid inducer of human melanoma caspase-dependent cell death that is mediated by oxidative stress."
4.	Skin Neoplasms (Skin Cancer) 07/01/2007 - "Based on this data, we suggest that sanguinarine could be developed as an agent for the management of conditions elicited by UV exposure including skin cancer. " 07/01/2007 - "Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin: implications for prevention of skin cancer." 08/01/2003 - "We suggest that sanguinarine could be developed as a drug for the management of hyperproliferative skin disorders, including skin cancer." 12/01/2009 - "Data from the present study support the concept that sanguinarine can be effective in melanoma skin cancer."
5.	Hemorrhage 08/01/1989 - "However, neither the phenolic nor sanguinarine rinses were significantly different than placebo in their effects on gingivitis or gingival bleeding. " 05/10/1991 - "[Efficacy of chlorhexidine digluconate and sanguinarine on plaque and bleeding index]."

Related Drugs and Biologics

1.	Toothpastes
2.	Dentifrices (Dentifrice)
3.	chlorhexidine gluconate (Dyna-Hex)
4.	argemone oil
5.	chelerythrine
6.	mustard oil
7.	sanguinarine
8.	DNA (Deoxyribonucleic Acid)
9.	Brefeldin A
10.	2,3- bis(2- hydroxyethylsulfanyl)- (1,4)naphthoquinone

Related Therapies and Procedures

1.	Oral Administration
2.	Heterologous Transplantation (Xenotransplantation)
3.	Traditional Medicine (Folk Remedies)