safingol (sphinganine)

RN given refers to the (R-(R*,S*))-isomer

Also Known As:

sphinganine; 2-aminooctadecane-1,3-diol; SPC 100270; SPC-100270; dihydrosphingosine; erythro-D-sphinganine; safingol hydrochloride; safingol, ((R*,S*)-(+-))-isomer; safingol, (R-(R*,R*))-isomer; safingol, (S-(R*,S*))-isomer; saginfol; threo-dihydrosphingosine

Networked: 170 relevant articles (6 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Sphingosine: 899
      - safingol: 170
- Alcohols: 595
  - Glycols: 38
    - Sphingosine: 899
      - safingol: 170
  - Amino Alcohols: 20
    - Sphingosine: 899
      - safingol: 170

Experts

1.	Chiu, Gigi N C: 4 articles (08/2014 - 12/2009)
2.	Ling, Leong-Uung: 4 articles (08/2014 - 12/2009)
3.	Tan, Kuan-Boone: 4 articles (08/2014 - 12/2009)
4.	Merrill, Alfred H: 4 articles (04/2011 - 01/2007)
5.	Ahn, Eun Hyun: 4 articles (07/2010 - 05/2002)
6.	Schroeder, Joseph J: 4 articles (07/2010 - 05/2002)
7.	Chabowski, Adrian: 3 articles (06/2021 - 03/2013)
8.	Hamada, Masakazu: 3 articles (01/2016 - 03/2009)
9.	Iwai, Soichi: 3 articles (01/2016 - 03/2009)
10.	Yura, Yoshiaki: 3 articles (01/2016 - 03/2009)

Related Diseases

1.	Overweight 10/13/2023 - "This study demonstrates that RIF is associated with improvements in plasma sphingosine, sphinganine sphingomyelin, and dihydrosphingomyelin lipid species, as well as improved lipid profile and inflammatory markers, which may confer short-term protection against cardiometabolic problems in patients with overweight/obesity."
2.	Obesity 10/13/2023 - "This study demonstrates that RIF is associated with improvements in plasma sphingosine, sphinganine sphingomyelin, and dihydrosphingomyelin lipid species, as well as improved lipid profile and inflammatory markers, which may confer short-term protection against cardiometabolic problems in patients with overweight/obesity."
3.	Infections 01/01/2021 - "We found that sphinganine (Sa) (d16:0) exhibited obvious depletion after infection; moreover, its level in patients with T. " 09/01/2011 - "The resistance of the null mpk6 mutant to manifest PCD on FB1 and sphinganine addition and the failure to show resistance on pathogen infection and MPK6 activation by FB1 and LCBs indicated that MPK6 mediates PCD downstream of LCBs. " 06/13/2016 - "Sphingosine and sphinganine values were significantly upregulated in patients unable to clear HCV over time compared to patients with spontaneous clearance of HCV infection on follow-up (p = 0.013 and 0.006, respectively). " 06/13/2016 - "In summary, the persistence of HCV after acute infection induces a downregulation of C24Cer and a simultaneous elevation of serum sphingosine and sphinganine concentrations. " 09/24/2010 - "Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana."
4.	Inflammation (Inflammations) 04/01/1996 - "In addition, safingol produced hepatocyte cell death without inflammation in vivo, and a "ladder-like" DNA fragmentation pattern in vitro, consistent with an apoptotic mechanism of cell death." 09/01/1995 - "The candida infections, treated daily with 1.5% sphinganine in ethanol, showed no improvement in inflammation compared with controls, except for 2 days of the 2-week observation period (P = 0.01-0.03); however, by the fourth day of therapy the yeast was eliminated in 75% of animals. " 11/01/2019 - "The ceramide precursors Sphingosine, Sphinganine, Sphingomyelin, correlated with inflammation, whilst the oxidative stress marker isoprostane correlated with inflammation and chest CT scores. " 01/01/2023 - "Lipidomic profiling revealed that the levels of palmitic acid, ceramides, and sphingosine-1-phosphate were higher in the lungs of ovalbumin-immunized Elovl6-/- mice compared with those of wild-type mice, while the aggravated airway inflammation was ameliorated by treatment with fumonisin B1 or DL-threo-dihydrosphingosine, inhibitors of ceramide synthase and sphingosine kinase, respectively. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 06/10/2012 - "In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia." 08/01/2014 - "The aim of this work was to develop a liposomal formulation to facilitate delivery of a synergistic safingol/C2-ceramide combination in the treatment of acute myeloid leukemia (AML). " 12/08/2017 - "To assess the presence of potential abnormalities that might promote dysfunction of leukemic cells growth, HPLC system was used to determine sphingosine (SFO), sphinganine (SFA), sphingosine-1-phosphate (S1P) and ceramide (CER) concentration in the blood collected from patients diagnose with acute myeloblastic leukemia (AML; n = 49) and compare to values of control (healthily) group (n = 51). "

Related Drugs and Biologics

1.	Sphingosine
2.	Sphingomyelins
3.	Lipids
4.	Fluconazole (Zonal)
5.	Ethanol (Ethyl Alcohol)
6.	Sphingolipids
7.	Ceramides
8.	safingol (sphinganine)
9.	fumonisin B1
10.	Fumonisins

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Organ Transplantation
4.	Oral Administration