honokiol

11/01/2010 - "Topical treatment of mice with honokiol in a hydrophilic cream-based topical formulation before or after UVB (180 mJ/cm(2)) irradiation resulted in a significant protection against photocarcinogenesis in terms of tumor multiplicity (28-60%, P < 0.05 to <0.001) and tumor volume per tumor-bearing mouse (33-80%, P < 0.05 to 0.001, n = 20). "
11/01/2018 - "In present review, the published data on the efficacy of honokiol against various cancer cell lines and tumor-bearing animal models has been presented and discussed. "
09/28/2013 - "Thus, honokiol treatment may help to prevent tumor-promoting effects of CsA in transplant patients."
07/01/2012 - "We investigated the efficacy of honokiol in mice harboring tumors of HTLV-1-infected T-cell origin. "
12/01/2023 - "In this study, 21 new honokiol derivatives were synthesised, and their anti-cancer properties were investigated. "

01/01/2017 - "Honokiol improved cell survival and chondrogenesis of hUC-MSCs and inhibited IL-1β-induced inflammatory response, which suggested that combination of anti-inflammation and stem cell can be a novel strategy for better cartilage repair."
05/21/2009 - "In conclusion, the present study demonstrates for the first time that honokiol exhibits protective effects against eccentric exercise-induced skeletal muscle damage in rats, probably by modulating inflammation-mediated damage to muscle cells."
01/01/2017 - "Honokiol improved chondrogenesis and suppressed inflammation in human umbilical cord derived mesenchymal stem cells via blocking nuclear factor-κB pathway."
07/01/2021 - "Honokiol protects the liver, kidneys, nervous system, and cardiovascular system through reducing oxidative stress and relieving inflammation. "
06/01/2019 - "The expression patterns of oxidative stress moleculars and TLRs-mediated inflammation pathway were examined to identify the response of NRK-52E cells incubated with septic rats' serum to honokiol. "

01/05/2022 - "Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response."
01/05/2016 - "Honokiol (10mg/kg) treated group depicted marked reduction in cognitive impairment and depressive-like behaviour. "
01/05/2016 - "Honokiol abrogates chronic restraint stress-induced cognitive impairment and depressive-like behaviour by blocking endoplasmic reticulum stress in the hippocampus of mice."
11/01/2014 - "This study suggested that delayed intravenous administration of Honokiol could effectively ameliorate TBI-induced sensorimotor and cognitive dysfunctions. "
01/05/2016 - "The primary objective of our study is to investigate the neuroprotective efficacy of honokiol and imipramine against restraint stress (RS)-induced cognitive impairment and depressive-like behaviour in mice. "

01/01/2018 - "Taken together, this study demonstrated the improved effects of honokiol with TMZ on autophagy and subsequent apoptosis of drug-sensitive and -tolerant glioma cells. "
01/01/2018 - "This study was further aimed to evaluate the improved effects of honokiol and TMZ on drug-sensitive and -resistant glioma cells and the possible mechanisms. "
10/01/2018 - "The honokiol-involved improvement in TMZ-induced intrinsic apoptosis was also confirmed in human U373 MG and murine GL261 glioma cells. "
01/01/2018 - "The improved effects of honokiol on TMZ-induced cell insults were further verified in mouse GL261 glioma cells. "
10/01/2018 - "This study showed that honokiol can enhance TMZ-induced apoptotic insults to glioma cells via an intrinsic mitochondrion-dependent mechanism. "

01/01/2016 - "Protective effects of honokiol on ischemia/reperfusion injury of rat ovary: an experimental study."
01/01/2016 - "The purpose of this study was to investigate the protective effect of honokiol on experimental ischemia/reperfusion injury of rat ovary. "
01/23/2013 - "Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction."
08/01/2007 - "It is concluded that honokiol can protect brain against ischaemic reperfusion injury and preserve mitochondrial function from oxidative stress. "
07/01/2019 - "Honokiol post-treatment ameliorates myocardial ischemia/reperfusion injury by enhancing autophagic flux and reducing intracellular ROS production."