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phenylmethylpyrazolone

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structure in second source; free radical scavenger; has strong antiedema activity

Also Known As:

1-phenyl-3-methyl-5-pyrazolone; 3-methyl-1-phenyl-2-pyrazolin-5-one; MCI 186; MCI-186; edarabone; edaravone; norantipyrine; norphenazone; 3H-pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-

Networked: 472 relevant articles (112 outcomes, 124 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Pyrazoles: 26
      - Pyrazolones: 31
        Antipyrine: 475
        phenylmethylpyrazolone: 472

Experts

1.	Abe, Koji: 18 articles (07/2015 - 11/2003)
2.	Deguchi, Kentaro: 7 articles (11/2014 - 04/2009)
3.	Mitsuno, Masataka: 7 articles (09/2014 - 01/2007)
4.	Yamamura, Mitsuhiro: 7 articles (09/2014 - 01/2007)
5.	Tanaka, Hiroe: 7 articles (09/2014 - 01/2007)
6.	Miyamoto, Yuji: 7 articles (09/2014 - 01/2007)
7.	Ryomoto, Masaaki: 6 articles (09/2014 - 01/2007)
8.	Yamashita, Toru: 5 articles (11/2014 - 04/2009)
9.	Kikuchi, Kiyoshi: 5 articles (01/2013 - 06/2009)
10.	Shioda, Seiji: 5 articles (01/2013 - 01/2002)

Related Diseases

1.	Stroke (Strokes) 11/01/2012 - "An optimal treatment for stroke in children has not been established, and this case highlights the urgent need to examine the safety and efficacy of IV t-PA and edaravone therapy for ischemic stroke in children." 01/01/2011 - "Edaravone is a neuroprotective agent that has been widely used in China, and several studies have suggested that it may be beneficial in acute ischaemic stroke. " 07/01/2010 - "Efficacy of edaravone ranges from large significant clinical improvements to only modest improvements in clinical function measured using standard stroke scales when administered 6-72 h following an ischemic stroke. " 01/01/2008 - "Edaravone, clinically available free radical scavenger in Japan, is confirmed to be beneficial in the acute stage of stroke. " 02/21/2014 - "Edaravone, an electron spin trapper with radical scavenging activity, has been shown to be effective in reducing infarct volume in humans following ischemic stroke. "
2.	Ischemia 07/01/2008 - "Infarct volume was significantly reduced by DOT (100, 200 and 400 mg/kg; P < 0.05), and edaravone plus DOT markedly improved the survival rate after transient ischemia (P = 0.0133). " 12/25/2009 - "In this study, edaravone significantly reduced the infarct area and improved the neurological deficit scores at 24h after reperfusion in a rat transient focal ischemia model. " 01/06/2012 - "Edaravone also significantly reduced the locomotor activity deficit 72h after ischemia and improved memory impairment. " 10/01/2005 - "Edaravone, even when administrated 6 hours after onset of ischemia/reperfusion, significantly reduced the infarct volume (68.10+/-6.24%; P<0.05) and improved the neurological deficit scores (P<0.05) at 24 hours after reperfusion. " 08/20/2008 - "Previous reports have confirmed that edaravone has protective effects against ischemia-reperfusion (IR) injury of many organs. "
3.	Reperfusion Injury 07/01/2009 - "Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a newly developed hydroxy radical scavaging agent which has been widely used for protection against ischemia-reperfusion injury is highly effective in preventing cell apoptosis. " 08/01/2004 - "The purpose of this study was to investigate whether or not MCI-186 is effective in reducing ischemia-reperfusion injury in the extremities. " 08/01/2004 - "MCI-186 is effective in preventing ischemia-reperfusion injury in extremities. " 05/01/2008 - "Edaravone has protective effects on renal ischemia-reperfusion injury in rats." 05/01/2008 - "[Protective effects of edaravone on renal ischemia-reperfusion injury in rats]."
4.	Cerebral Infarction 02/01/2006 - "Edaravone, clinically available free radical scavenger in Japan, is confirmed to be beneficial in the acute stage of cerebral infarction. " 01/01/2013 - "These findings suggest that edaravone treatment would be effective in clinical patients recovering from cerebral infarction." 10/01/2006 - "Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, is clinically effective in improving the prognosis after cerebral infarction. " 10/01/2007 - "The mechanism by which MCI-186 (3-methyl-1-phenyl-2-prazolin-5-one) exerts protective effects during cerebral infarction, other than its function as a radical scavenger, has not been fully elucidated. " 01/01/2009 - "Although there was a randomized, placebo-controlled, double-blind study at multiple centers in Japan showing the efficacy of the free radical scavenger, edaravone, in acute cerebral infarction, to date the clinical studies are few. "
5.	Brain Ischemia (Cerebral Ischemia) 01/06/2012 - "The present study investigates the neurological protective effects of edaravone against global brain ischemia. " 03/01/1994 - "Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions." 08/01/2012 - "Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat." 11/01/2014 - "The present study demonstrates that exogenous tPA strongly damages pericytes and destroys the integrity of the NVU, but edaravone treatment can greatly ameliorate such damage after acute cerebral ischemia in rats." 01/01/2014 - "In the present study, we explored whether pre- and posttreatment of edaravone had any effect on neural stem/progenitor cells (NSPCs) in the subgranular zone of hippocampus in a rat model of transient global cerebral ischemia and elucidated the potential mechanism of its effects. "

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